Day: August 17, 2020

1287-16-7, Ferrocenylacetic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1) 1.2 mmol of ferrocenyl acetic acid and 1 mmol of 3- (2,4-dichlorophenyl) -4-amino-5-mercapto-1,2,4-triazole were weighed out,Added to a dry 250mL single-necked flask,Then p-toluenesulfonic acid 0.12 mmol,7 mL of DMF was further added thereto,The glass rod is stirred to dissolve it.2)The round bottom flask was placed in a microwave reactor,370W under irradiation once every 30s,Irradiation duration of 4min.After irradiation,cool down.3)Pour it into a crushed beaker,With potassium carbonate and potassium hydroxide pH = 7,Placed overnight,filter,Washed,dry,Thus, 3- (2,4-dichlorophenyl) -6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole was obtained product,Using a solvent of DMF and absolute ethanol in a volume ratio of 4: 1 mixed solvent,The crude product was recrystallized,That is, a brown solid,The yield is 82%

The synthetic route of 1287-16-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shaanxi University of Science and Technology; Liu, Yuting; Song, Simeng; Yin, Dawei; Jiang, Shanshan; Liu, Beibei; Yang, Aning; Wang, Jinyu; Lyu, Bo; (13 pag.)CN104231004; (2017); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-42-7,Ferrocenecarboxylic acid,as a common compound, the synthetic route is as follows.

under ice-cooling, 11.5 g (0.05 mol) of ferrocenecarboxylic acid was mixed with 100 mL of dichloromethane (DCM) and homogenized with stirring. Under strong stirring, 7.0 g (0.06 mol) of N-hydroxysuccinimide was added to the above reaction system.(NHS), 11.5g (0.06mol)1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl).Under the ice bath,After 4 to 6 hours of reaction, the solution gradually clarified and the reaction was monitored by TLC. After the reaction is completed, suction filtration gives the dichloromethane of the intermediate (1).

As the paragraph descriping shows that 1271-42-7 is playing an increasingly important role.

Reference£º
Patent; Shandong University; Yan Bing; Zhang Congcong; Wang Shenqing; Jiang Cuijuan; Zhai Shumei; Zhang Qiu; (16 pag.)CN107722067; (2018); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14024-18-1,Iron(III) acetylacetonate,as a common compound, the synthetic route is as follows.

Monodispersed Fe3O4 nanoparticles having a mean diameter of 8 nm were synthesized following the seed-growth method described by Sun et al. (J. Am. Chem. Soc., 2004, 126, 273-279). To that end, 6 nm Fe3O4 seeds were synthesized by mixing Fe(acac)3 (2 mmol), 1,2-hexadecanediol (10 mmol), oleic acid (6 mmol), oleylamine (6 mmol), and benzyl ether (20 mL) under nitrogen flow. The mixture was heated at 200 C. for 2 hours and was then kept under reflux (300 C.) for 1 hour. The solution was cooled to room temperature and was then washed with methanol to remove the solvent and to finally be redispersed in hexane. The 6 nm nanoparticles to produce 8 nm nanoparticles were re-grown as indicated above and by adding 84 mg of 6 nm nanoparticles dispersed in hexane.

As the paragraph descriping shows that 14024-18-1 is playing an increasingly important role.

Reference£º
Patent; Nanoimmunotech SRL; Universidad de Zaragoza; Fundacion Agencia Aragonesa Para la Investigacion y el Desarollo; Del Pino Gonzalez de la Higuera, Pablo Alfonso; Martinez de la Fuente, Jesus; Sanchez Espinel, Christian; Santos Martinez de Laguna, Ruben; US2014/275509; (2014); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-82-1,Aminoferrocene,as a common compound, the synthetic route is as follows.

This amino-ferrocene (1.07 g, 5.32 mmol) was dissolved in acetic acid (15 ml.) under nitrogen and paraformaldehyde (1.59 g, 53.2 mmol) and NaBH3CN (1.67 g, 26.6 mmol) was added and the reaction mixture was stirred for 16 h. Aqueous NaOH 6 M was added until pH = 12 and the solution was extracted by hexane (3 x 20 ml_). The combined organic phase was washed with brine, dried with Na2S04 and the solvent was removed under vacuum until approximately 5% of the initial volume. The residue was subjected to quick filtration through a pad of silica gel eluting with hexane. The solvent was removed under vacuum not to complete dryness so as the pure product crystallized in the freezer as orange flakes; mp 69- 70 C; NMR (CDCI3, ppm): 1H (500 MHz) 4.25, 3.95, 3.76, 2.59; 13C (126 MHz) 155.80, 66.50, 63.07, 54.61 , 41.50.

1273-82-1 Aminoferrocene 72747180, airon-catalyst compound, is more and more widely used in various.

Reference£º
Patent; NATIONAL CENTRE FOR SCIENTIFIC RESEARCH “DEMOKRITOS”; PELECANOU ZAMPARA, Maria; SAGNOU, Marina; PAPADOPOULOS, Minas; PIRMETTIS, Ioannis; MAVROIDI, Barbara; SHEGANI, Antonio; (38 pag.)WO2019/180200; (2019); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-82-1,Aminoferrocene,as a common compound, the synthetic route is as follows.

5) 402 mg (2.0 mmol) of FcNH2 was added to the above system and the reaction was continued for 16 hours; The solvent was evaporated under reduced pressure, The residue was extracted with CH2Cl2, Thin layer chromatography was carried out using methylene chloride / petroleum ether = 1: 2 (v / v) as a developing solvent, Collect the red main ribbon,To give a model 1 (325 mg) Yield 28%.

As the paragraph descriping shows that 1273-82-1 is playing an increasingly important role.

Reference£º
Patent; Nankai University; Song, Licheng; Lu, Yu; Peng, Fei; Yang, Xiyue; (6 pag.)CN105601678; (2016); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12126-50-0,Bis(pentamethylcyclopentadienyl)iron(II),as a common compound, the synthetic route is as follows.

Salt 1 was synthesized as follows. Under a nitrogen atmosphere,SO2Cl2 (0.025 mL, 0.31 mmol) was added dropwise to a dichloromethanesolution (0.5 mL) of [FeCp*2] (48 mg, 0.15 mmol) andstirred for 15 min. The solvent was then evaporated under reducedpressure and vacuum dried. The resulting dark green solid of[FeCp*2]Cl was dissolved in water (0.5 mL), to which an aqueoussolution (0.2 mL) of K [CH2BrBF3] (54 mg, 0.27 mmol) was added and stirred for 15 min. The resulting precipitate was collected by filtration and washed with ether, followed by drying under vacuumto obtain the desired product as a dark green solid. Recrystallizationby slow cooling (-40 C) of an ether-dichloromethane solution ofthe solid afforded dark green block crystals of 1 (31.5 mg, yield 43%). Anal. Calcd. For C21H32F3BBrFe: C, 51.68; H, 6.65; N, 0.00.Found: C, 51.88; H, 7.05; N, 0.00. IR (cm-1): 2949, 1474, 1424, 1381,1186, 1124, 1104, 1081, 1043, 1025, 996, 968, 954, 742, 722, 619, 593,531.

The synthetic route of 12126-50-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kimata, Hironori; Mochida, Tomoyuki; Journal of Organometallic Chemistry; vol. 895; (2019); p. 23 – 27;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12093-10-6,Ferrocenecarboxaldehyde,as a common compound, the synthetic route is as follows.

(2) Synthesis of ferrocene methanol: ferrocene formaldehyde (10 g, 0.047 muM) dissolved in anhydrous ethyl ether in, and transfer it to the constant pressure in the dropping funnel; in three-neck round bottom flask is added in the tetrahydro (1.8 g, 0 . 047 muM), under the protection of the helium, the ferrocene formaldehyde solution is slowly dripped into stirring in in the tetrahydro solution, then completing after 45 C reflow 2 h, for at the same time thin-layer chromatographic monitoring the reaction; after the reaction, cooling to room temperature, then adding 60 ml ethyl ether, excessive cooling of the tetrahydro adding ethyl acetate and water mixture is removed; separatory funnel for the organic layer is separated out, and washing by water three times (once for each 100 ml water); and organic water-free magnesium sulfate drying 24 h after, for after the Rotavapor distillation under reduced pressure, to obtain yellow powder 7.32 g, yield 97%, melting point 76 – 78 C.

The synthetic route of 12093-10-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong Yuangen Petrochemical Co., Ltd.; Qiao Liang; Yuan Junzhou; Song Laigong; He Jingsong; Liu Shanshan; (7 pag.)CN104710482; (2018); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-82-1,Aminoferrocene,as a common compound, the synthetic route is as follows.

General procedure: Organometallic sulfonamides were prepared following a modification of the procedure described by Alberto and co-workers [41]. An equimolar amount of pyridine was added at room temperature to a solution containing 50mg of P2 or P3 in 7.0mL of anhydrous CH2Cl2. After 15min, the corresponding sulfonyl chloride derivative was added, and the reaction mixture was heated under reflux for 24h. The resulting solution was dried under vacuum. The crude product was purified using silica gel liquid chromatography and a mixture of CH2Cl2/hexane (4:1) as the eluent. All compounds were recrystallized from an acetone/hexane (1:5) mixture by slow evaporation.

As the paragraph descriping shows that 1273-82-1 is playing an increasingly important role.

Reference£º
Article; Quintana, Cristobal; Silva, Gisella; Klahn, A. Hugo; Artigas, Vania; Fuentealba, Mauricio; Biot, Christophe; Halloum, Iman; Kremer, Laurent; Novoa, Nestor; Arancibia, Rodrigo; Polyhedron; vol. 134; (2017); p. 166 – 172;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-55-2,Acetylferrocene,as a common compound, the synthetic route is as follows.

General procedure: To a solution of acetyl ferrocene (228 mg, 1mmol) in ethyl alcohol (15 ml) was added KOH (110 mg, 2 mmol) and stirred at room temperature for 15 min, then appropriate aromatic aldehyde (1 mmol) in ethyl alcohol (5 ml) was slowly added and the mixture was allowed to stirred at room temperature. After complete consumption of acetyl ferrocene (monitored by TLC, a red to purple colour solid was formed), 2-hydrazinobenzothiazole (165 mg, 1.0 mmol), KOH (110 mg, 2 mmol) and additional ethyl alcohol (5 ml) and was slowly added and the resulting mixture was refluxed for overnight. After completion of the reaction (monitored by TLC, an orange to red colour solid was formed), the reaction mixture was cooled, the solid formed was filtered, washed with cold ethanol-water mixture, water and air dried. The resulting solid was purified by column chromatography using n-hexane/ethyl acetate mixture (9:1 to 8:2) to obtain the ferrocene derivative.

The synthetic route of 1271-55-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kiran Kumar, Chakka; Trivedi, Rajiv; Giribabu, Lingamallu; Niveditha, Surukonti; Bhanuprakash, Kotamarthi; Sridhar, Balasubramanian; Journal of Organometallic Chemistry; vol. 780; (2015); p. 20 – 29;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1287-16-7, Ferrocenylacetic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 50mL three neck round bottom flask, ferroceneacetic acid (0.0600g, 0.25mmol), oxalyl chloride (21.8muL, 0.25mmol), pyridine (20.1muL, 0.25mmol) and 4-(1H-pyrrol-1yl)phenol (0.0398g, 0.25mmol) were reacted in 10mL of dichloromethane (DCM) under nitrogen atmosphere at room temperature. The reaction was carried out for 12h to get 4(1H-pyrrol-1-yl)phenyl ferroceneacetylate. After that period three consecutive washing with 0.01M HCl were carried out. The organic phase was then dried over sodium sulfate. The product was separated by column chromatography using silica gel and DCM as mobile phase. Fc-CH2CO2-Ph-4-Py was isolated in 62% yield.

1287-16-7 Ferrocenylacetic acid 73425372, airon-catalyst compound, is more and more widely used in various.

Reference£º
Article; Perez, Wanda I.; Soto, Yarelys; Ortiz, Carmen; Matta, Jaime; Melendez, Enrique; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 471 – 479;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion