With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-42-7,Ferrocenecarboxylic acid,as a common compound, the synthetic route is as follows.
under ice-cooling, 11.5 g (0.05 mol) of ferrocenecarboxylic acid was mixed with 100 mL of dichloromethane (DCM) and homogenized with stirring. Under strong stirring, 7.0 g (0.06 mol) of N-hydroxysuccinimide was added to the above reaction system.(NHS), 11.5g (0.06mol)1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl).Under the ice bath,After 4 to 6 hours of reaction, the solution gradually clarified and the reaction was monitored by TLC. After the reaction is completed, suction filtration gives the dichloromethane of the intermediate (1).
As the paragraph descriping shows that 1271-42-7 is playing an increasingly important role.
Reference£º
Patent; Shandong University; Yan Bing; Zhang Congcong; Wang Shenqing; Jiang Cuijuan; Zhai Shumei; Zhang Qiu; (16 pag.)CN107722067; (2018); A;,
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