Day: August 19, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.

In anhydrous THF (1 mL) was dissolved 6 molpercent Cu(OAc) 2 (10.9 mg,0.066 mmol) and 6.6 molpercent of ligand (R)-DTBM-SEGPHOS (78 mg,0.060 mmol). The mixture was stirred for 15 min at r.t., then DMMS(0.5 mL, 4 equiv, 4 mmol) was added dropwise and stirring was con-tinued for 10 min at the same temperature. The solution of amine 7(381 mg, 1.2 mmol) and vinylferrocene 4 (212 mg, 1 mmol) was thenadded by using Schlenk techniques to the tube containing the solu-tion of [L*CuH] complex. The reaction mixture was stirred at 40 ¡ãCovernight, then the mixture was diluted with EtOAc (5 mL) and 5percentsolution of Na 2 CO 3 (5 mL) was added dropwise. The solution was ex-tracted with EtOAc (3 ¡Á 25 mL), the collected organic layers werewashed with brine (25 mL), dried over Na 2 SO 4 , filtrated, and the sol-vent was removed under reduced pressure to afford the crude prod-uct. The crude product was purified by chromatography on SiO 2 (hex-anes/EtOAc, 30:1 + 1percent Et 3 N; R f = 0.4) to afford target product 8.Yield: 68 mg (18percent); orange solid; mp 62?65 ¡ãC; [alpha] D20 ?14.5 (c 1.00,CHCl 3 ); HPLC analysis (Chiralcel OD-H; hexane/ i PrOH, 99:1; 0.8mL/min; 254 nm) indicated 20percent ee: t R = 5.9 (major), 6.5 (minor) min.IR (ATR): 1234, 1103, 1068, 1022, 998, 822, 749, 728, 697, 514, 487cm ?1 .1 H NMR (600 MHz, CDCl 3 ): delta = 7.39 (d, J = 7.4 Hz, 4 H, -Ph), 7.31 (t, J =7.6 Hz, 4 H, -Ph), 7.23 (t, J = 7.3 Hz, 2 H, -Ph), 4.27?4.27 (m, 1 H, Fc),4.18?4.14 (m, 3 H, Fc), 4.02 (s, 5 H, Cp Fc ), 3.81 (q, J = 6.9 Hz, 1 H, H alpha ),3.53 (d, J = 14.1 Hz, 2 H, CH 2 -Ph), 3.36 (d, J = 14.1 Hz, 2 H, -CH 2 -Ph),1.47 (d, J = 6.9 Hz, 3 H, -CH 3 ).13 C NMR (151 MHz, CDCl 3 ): delta = 140.9 (2¡ÁC, Cq Ph ), 128.6 (4¡ÁC, -Ph),128.2 (4¡ÁC, -Ph), 126.7 (2¡ÁC, -Ph), 88.9 (Cq Fc ), 69.1 (-CH Fc ), 68.7 (5¡ÁC,Cp Fc ), 67.6 (-CH Fc ), 67.1 (-CH Fc ), 66.9 (-CH Fc ), 52.3 (2¡ÁC, -CH 2 -Ph), 52.2(-CH alpha ), 15.4 (-CH 3 ).HRMS (ESI): m/z calcd for [M + H + ] C 26 H 28 FeN + : 410.1571; found:410.1565.

The synthetic route of 1271-51-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Plevova, Kristina; Mudrakova, Brigita; ?ebesta, Radovan; Synthesis; vol. 50; 4; (2018); p. 760 – 763;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12093-10-6,Ferrocenecarboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: In a typical procedure, 1.39 mmol of 2?-hydroxyacetophenone (for 1 and 3) or 2?-hydroxy-4?-methoxyacetophenone (for 2 and 4) were dissolved in 40 ml of methanol. To this solution, 4 equivalent of potassium hydroxide were added and stirred for 15 min at room temperature. Then, 1.40 mmol of the appropriate ferrocenecarboxaldehyde derivative, (i.e. 1-ferrocenecarboxaldehyde for 1 and 2 or 1,1-ferrocenedicarboxaldehyde for 3 and 4) were added. The mixture was stirred during three days at room temperature. Then, methanol was evaporated in vacuum (rotary evaporator) and the crude reaction mixture was submitted to column chromatography (silica gel 60, Ethyl acetate: Hexane = 3:10 v/v).

As the paragraph descriping shows that 12093-10-6 is playing an increasingly important role.

Reference£º
Article; Trujillo, Alexander; Ocayo, Fernanda; Artigas, Vania; Santos, Juan C.; Jara-Ulloa, Paola; Kahlal, Samia; Saillard, Jean-Yves; Fuentealba, Mauricio; Escobar, Carlos A.; Tetrahedron Letters; vol. 58; 5; (2017); p. 437 – 441;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

General procedure: 1.1 mmol of triethylamine was added to a stirred mixture of 1.0 mmol of metallocene alcohol (7, 8, 12) or 0.45 mmol of ferrocene diol (10, 11) and 1.0 mmol of 4,5-dichloroisothiazole- or 5-arylisoxazole-3-carbonyl chloride in 50 mL of diethyl ether at 20-23C. The reaction mixture was stirred at that temperature during 24 h. The precipitated triethylamine hydrochloride was filtered off and washed with diethyl ether (5 ¡Á 10 mL). The filtrate was washed with 10 % aqueous NaCl and 5 % aqueous NaHCO3. The solvent was removed, and the residue was recrystallized from a benzene-hexane (2 : 1) mixture (14, 15, 19, and 20) or from hexane (16,17, 21, and 22). 3,4,4-Trichloro-1-cymantrenylbut-3-en-1-yl 4,5-dichloroisothiazole-3-carboxylate 18 was obtained as a viscous oil and was used without further purification.

The synthetic route of 1273-86-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Potkin; Dikusar; Kletskov; Petkevich; Semenova; Kolesnik; Zvereva; Zhukovskaya; Rosentsveig; Levkovskaya; Zolotar; Russian Journal of General Chemistry; vol. 86; 2; (2016); p. 338 – 343; Zh. Obshch. Khim.; vol. 86; 2; (2016); p. 338 – 343,6;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of ferrocenyl alcohol 1 or 2 (2.0 mmol) and correspondingmercapto derivative in dry MeNO2 (5 mL) CAN (22 mg,0.04 mmol, 0.2 mol%) was added. The resulting mixture was stirredat room temperature until TLC analysis revealed complete disappearanceof starting alcohol 1 or 2 (usually 3-4 h). Then reactionmixture was poured onto a water (40 mL), organic layer was separated,the aqueous phase was extracted with EtOAc (2 10 mL),and the combined organic solution was dried over Na2SO4, filteredand the solvents were evaporated in vacuo. The remained productwas treated with CH2Cl2 (50 ml) and passed through a silica gellayer (2.5 cm) on the filter to give corresponding products 5-9,11 after the evaporation of volatiles at reduced pressure.

As the paragraph descriping shows that 1273-86-5 is playing an increasingly important role.

Reference£º
Article; Ol’shevskaya, Valentina A.; Makarenkov, Anton V.; Borisov, Yury A.; Ananyev, Ivan V.; Kononova, Elena G.; Kalinin, Valery N.; Ponomaryov, Andrey B.; Polyhedron; vol. 141; (2018); p. 181 – 190;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: ferrocenemethanol was added to the substrates 1a-l in a round bottomflask and the mixture was heated under stirring at 50-90C (as reported in Table 1), the reaction was monitored byTLC and capillary electrophoresis, after completion of reaction. The reactionmixture was flash chromatographed by silica gel column to give the purecompounds 3a-l as reported in Table 1. Typical eluent: hexane/ethyl acetate= 7/3.

The synthetic route of 1273-86-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shisodia, Suresh Udhavrao; Auricchio, Sergio; Citterio, Attilio; Grassi, Marco; Sebastiano, Roberto; Tetrahedron Letters; vol. 55; 4; (2014); p. 869 – 872;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

12093-10-6, Ferrocenecarboxaldehyde is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2: Synthesis of ferrocenyl chalcones 1 a-f General preparation of ferrocenyl chalcones: Ferrocene carboxaldehyde (1 eq) and the appropriate 2-hydroxyacetophenone (1 eq) were dissolved in absolute ethanol (40 mL) in a 100 mL two necked round bottom flask. After stirring the mixture 10 to 15 min. at room temperature, sodium hydroxide (3 eq) was added, and the solution was stirred overnight. The mixture was poured into water (100 mL) and hydrochloric acid (12 M, 15 mL), extracted with dichloromethane (3 x 50 mL), and washed with water. The organic phase was dried over magnesium sulfate, filtered, and the solvent removed by evaporation. The product was purified by silica gel chromatography, using a mixture of petroleum ether/dichloromethane 4:1 as an eluent, and again using HPLC in acetonitrile/water (90:10). After HPLC purification, the acetonitrile was removed under reduced pressure and the aqueous phase extracted with dichloromethane.

As the paragraph descriping shows that 12093-10-6 is playing an increasingly important role.

Reference£º
Patent; Centre National de la Recherche Scientifique (CNRS); EP2368895; (2011); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.

5-Iodo-2′-deoxyuridine was allowed to react at 60 ¡ãC for 48 h under basic conditions in CH3CN with vinylferrocene (1.2 equiv.) in the presence of palladium acetate (0.01 equiv.) and triphenylphosphine (0.02 equiv.), which afforded the coupling product 1 in 43percent yield.

The synthetic route of 1271-51-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hasegawa, Yusuke; Takada, Tadao; Nakamura, Mitsunobu; Yamana, Kazushige; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3555 – 3557;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-42-7,Ferrocenecarboxylic acid,as a common compound, the synthetic route is as follows.

A solution of ferrocenecarboxylic acid (232.1 mg, 1 mmol), DIPEA (680 muL, 4 mmol), TBTU (321.1 mg, 1 mmol) and HOBt (135.1 mg, 1 mmol) in dichloromethane (20 ml) was stirred at room temperature for 1 hour. N-Boc-ethylenediamine (158 muL, 1 mmol) was added and the stirring continued for 2 days. The reaction mixture was washed with NaHCO3, brine and citric acid, the organic layer dried over anhydrous sodium sulfate, filtered and evaporated in a vacuum. The crude product was purified by automated flash chromatography (20 % to 80 % ethyl-acetate in n-hexane), Rf = 0.13, EtOAc : hexane = 1 : 1. Yield: 276.7 mg (0.74 mmol, 74 %) of orange powder, Mr (C18H24FeN2O3) = 372.24. ESI-MS (m/z): 395.0 (M+Na+, 66%), 767.1 (2M+Na+, 67%). 1H NMR (300 MHz, CDCl3) delta/ppm: 6.56 (s, 1H), 5.03 (s, 1H), 4.76-4.62 (m, 2H), 4.41-4.28 (m, 2H), 4.21 (s, 5H), 3.56 – 3.43 (m, 2H), 3.37 (t, J = 5.6 Hz, 2H), 1.46 (s, 9H) 13C NMR (150 MHz, CDCl3) delta/ppm: 171.20, 157.40, 79.95, 76.09, 70.55, 69.90, 68.30, 41.22, 40.82, 28.57. IR (KBr) max/cm-1: 3374, 3245, 3002, 2976, 2928, 2880, 1687, 1640, 1536, 1453, 1364, 1267, 1170, 1018, 819, 718, 504, 486. IR (CHCl3, 40 mmol/L) max/cm-1: 3449, 3364, 3008, 2982, 2930, 1700, 1643, 1517, 1368, 1285, 1250, 1167, 998, 826, 483. UV-Vis (CHCl3) lambdamax (epsilon): 443 (219), 350 (431), 306 (1000).

The synthetic route of 1271-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Juraj, Natalija P.; Le Pennec, Jeremy; Peri?, Berislav; Kirin, Sre?ko I.; Croatica Chemica Acta; vol. 90; 4; (2017); p. 613 – 623;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

14024-18-1, Iron(III) acetylacetonate is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 100 mL Schlenk tube 1.00 g (2.83 mmol) of Iron(III)-acetylacetonate (Fe(AcAc)3), synthesized as reported in Bondioliet al., [13] was dissolved in different amounts of BzOH in order to evaluate the effect of the Fe(AcAc)3:BzOH ratio on the powder properties (see composition details in Table 1). The reaction was left stirring at room temperature for 15 min and then heated to 200C in an oil bath for 48 h. The main reaction occurring in the solvothermal treatment of Iron(III)-acetylacetonate in benzyl alcoholis summarized in the scheme of Fig. 1. After reaction a stable suspension was obtained. To better characterize the inorganic phase, the obtained powders were dispersed in methanol with an ultrasonic bath and centrifuged at 4000 rpm for 60 min; the powders were washed, centrifuged till the obtainment of a colourless liquid phase and finally dried under reduced pressure.

The synthetic route of 14024-18-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sciancalepore, Corrado; Bondioli, Federica; Messori, Massimo; Barrera, Gabriele; Tiberto, Paola; Allia, Paolo; Polymer; vol. 59; (2015); p. 278 – 289;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14024-18-1,Iron(III) acetylacetonate,as a common compound, the synthetic route is as follows.

A slurry of Fe(acac)3 (25 mg) in benzylalcohol (5.0 g)with carbon sphere (50 mg) was heated to 180 C under anargon atmosphere. The reaction mixture was maintainedat this temperature for 3 h, and the resulting dark-brownreaction mixture was cooled to room temperature. Theresidue was washed with ethanol to provide dark-brownCarbon/Fe3O4 powders with particle sizes of 320¡À27 nm.The Carbon/Fe3O4 powders were loaded in an aluminaboat in a box furnace and were annealed at 500 C for3 h under an atmospheric pressure of air, producing hollowFe2O3 nanospheres.

14024-18-1 Iron(III) acetylacetonate 91759530, airon-catalyst compound, is more and more widely used in various.

Reference£º
Article; Oh, Kyung Hee; Park, Hyung Ju; Kang, Shin Wook; Park, Ji Chan; Nam, Ki Min; Journal of Nanoscience and Nanotechnology; vol. 18; 2; (2018); p. 1356 – 1360;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion