With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12093-10-6,Ferrocenecarboxaldehyde,as a common compound, the synthetic route is as follows.
To a solution of ferrocenecarboxaldehyde (2) (4.28 g, 20 mmol) in acetone (100 mL) was added 2 N aq. NaOH (2 mL). The mixture was stirred at room temperature. After complete reaction (TLC analysis), the mixture was diluted with water and the precipitation was filtered to afford the crude product, which were purified by column chromatography using silica gel. 84% yield; brown solid, mp 125-127 C; 1H NMR (600 MHz, CDCl3): delta 7.42 (d, J = 16.0 Hz, 1H, CH=CH), 6.34 (d, J = 16.0 Hz, 1H, CH=CH), 4.50 (s, 2H, ferrocene-H), 4.44 (s, 2H, ferrocene-H), 4.15 (s, 5H, ferrocene-H), 2.29 (s, 3H, Me-H). MS (ESI): 255.1 (C14H14FeO, [M+H]+). Anal. Calcd for C14H14FeO: C, 66.17; H, 5.55; O, 6.30. Found: C, 66.23; H, 5.49; O, 6.36%.
The synthetic route of 12093-10-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Guo, Ying; Wang, Si-Qi; Ding, Zong-Qing; Zhou, Jia; Ruan, Ban-Feng; Journal of Organometallic Chemistry; vol. 851; (2017); p. 150 – 159;,
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