The iron-catalyst compound, cas is 12093-10-6 name is Ferrocenecarboxaldehyde, mainly used in chemical industry, its synthesis route is as follows.
General preparation of ferrocenyl chalcones: Ferrocene carboxaldehyde (1 eq) and the appropriate 2-hydroxyacetophenone (1 eq) were dissolved in absolute ethanol (40 ml.) in a 100 ml. two necked round bottom flask. After stirring the mixture 10 to 15 min. at room temperature, sodium hydroxide (3 eq) was added, and the solution was stirred overnight at room temperature, or 2-3h at reflux. The mixture was poured into water (100 ml.) and hydrochloric acid (12 M, 15 ml_), extracted with dichloromethane (3 x 50 ml_), and washed with water. The organic phase was dried over magnesium sulfate, filtered, and the solvent removed by evaporation. The product was purified by silica gel chromatography, using a mixture of petroleum ether/dichloromethane 4:1 as an eluent, and again using HPLC in acetonitrile/water (90:10). After HPLC purification, the acetonitrile was removed under reduced pressure and the aqueous phase extracted with dichloromethane.
With the rapid development of chemical substances, we look forward to future research findings about 12093-10-6
Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); HILLARD, Elizabeth; CHABOT, Guy; MONSERRAT, Jean-Philippe; JAOUEN, Gerard; TIWARI, Keshri Nath; DE MONTIGNY, Frederic; NEAMATI, Nouri; WO2011/107572; (2011); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
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