Day: August 27, 2020

A common heterocyclic compound, the iron-catalyst compound, name is Ferrocene,cas is 102-54-5, mainly used in chemical industry, its synthesis route is as follows.

To a three-neck flask, were added10.0 g of dry ferrocene (53.76 mmol) 150 mL of CH2Cl2. Then 39.2 g of triethylorthoformate (264.34) was added dropwise to the mixture with stirring. Afterthe ferrocene was completely dissolved, 30.0 g of mmol anhydrous AlCl3wasslowly added, and the reaction mixture was stirred at room temperature for4 h. Then the reaction was quenched with sodium hydrosulphite saturatedsolution (200 mL) and the mixture was extracted with diethyl ether (200 mL).After concentrated under reduced pressure, the residue was purified by chro-matography on silica gel (petroleum ether:ethyl acetate = 5:1) to afford 7 g redsolid with the yield of 70%.1H NMR (400 MHz, CDCl3) = 4.28 (s, 5H), 4.61 (s,2H); 4.80 (s, 2H), 9.96 (s, 1H).

As the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Article; I?ik, U?ur; Aydemir, Murat; Meric, Nermin; Durap, Feyyaz; Kayan, Cezmi; Temel, Hamdi; Baysal, Akin; Journal of Molecular Catalysis A: Chemical; vol. 379; (2013); p. 225 – 233;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

A common heterocyclic compound, the iron-catalyst compound, name is Ferrocenecarboxaldehyde,cas is 12093-10-6, mainly used in chemical industry, its synthesis route is as follows.

General procedure: In a typical procedure, 1.39 mmol of 2?-hydroxyacetophenone (for 1 and 3) or 2?-hydroxy-4?-methoxyacetophenone (for 2 and 4) were dissolved in 40 ml of methanol. To this solution, 4 equivalent of potassium hydroxide were added and stirred for 15 min at room temperature. Then, 1.40 mmol of the appropriate ferrocenecarboxaldehyde derivative, (i.e. 1-ferrocenecarboxaldehyde for 1 and 2 or 1,1-ferrocenedicarboxaldehyde for 3 and 4) were added. The mixture was stirred during three days at room temperature. Then, methanol was evaporated in vacuum (rotary evaporator) and the crude reaction mixture was submitted to column chromatography (silica gel 60, Ethyl acetate: Hexane = 3:10 v/v). (E)-3-Ferrocenyl-1-(2-hydroxyphenyl)-prop-2-en-1-one, (1). Yield 65% (605 mg), mp. 157-159.4 C. IR (KBr) cm-1: 3456 (OH), 3105 (C-H), 3086 (C-H), 1630 (C=O). 1H NMR (CDCl3, 400 MHz): delta 4.22 (5H, s, C5H5), 4.56 (2H, s, H-beta-C5H4), 4.65 (2H, s, H-alpha -C5H4), 6.95 (1H, t, J = 7.2 Hz, Harom), 7.26 (1H, d, J = 15 Hz, =CH), 7.45 (1H, t, J = 7.2 Hz, Harom), 7.88 (1H, d, J = 9.1 Hz, Harom), 7.92 (1H, d, J = 15 Hz, =CH), 13.08 (1H, s, OH). 13C NMR (CDCl3, 400 MHz): delta: 31.34, 69.51, 69.71, 70.36, 72.27, 117.15, 119.00, 119.10, 129.79, 136.30, 148.36, 164.03, 193.17. Uv-vis: 528 nm (704.5 cm-1M-1), 340 nm (8400 cm-1M-1). Analysis calculated for C19H16O2Fe: C, 68.70; H, 4.86. Found: C, 68.22; H, 4.76.

As the rapid development of chemical substances, we look forward to future research findings about 12093-10-6

Reference£º
Article; Trujillo, Alexander; Ocayo, Fernanda; Artigas, Vania; Santos, Juan C.; Jara-Ulloa, Paola; Kahlal, Samia; Saillard, Jean-Yves; Fuentealba, Mauricio; Escobar, Carlos A.; Tetrahedron Letters; vol. 58; 5; (2017); p. 437 – 441;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-82-1, Aminoferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The reaction step and the conditions of the step (2) are the same as those of the above step (1)The difference is that,4′-bromo-N, N-diphenylbiphenyl-4-amine was increased to 7.90 g (19.7 mmol)And purified by column chromatography,Need to be sublimated twice,To obtain a red compound Fc02 solid (yield 40%). A mixture of 300 mg (1.5 mmol) of the amine ferrocene obtained in Preparation Example 1, 1.8 g (4.5 mmol) of 4′-bromo-N, N-diphenylbiphenyl-4-amine (4′-bromo- -diphenylbiphenyl-4-amine),17 mg (0.075 mmol) of palladium acetate [Pd (OAc) 2]0.1 mL of a 10 wt% tributylphosphine n-hexane solution and 1.13 g (11.8 mmol) of sodium tert-butoxide(NaOtBu)And with 6 mL of toluene as solvent,After reacting at 130 C for 72 hours,The palladium catalyst was first removed by filtration through diatomaceous earth and silica gel,And rinsed with ethyl acetate to remove the solvent,And finally purified by column chromatography [4: 1 to 3: 2 (v / v) n-hexane and ethyl acetate gradient stripping system]To obtain the compound DPABPAFc (yield 50%The structure is shown in Reaction Scheme III).

As the paragraph descriping shows that 1273-82-1 is playing an increasingly important role.

Reference£º
Patent; Zheng, Jianhong; Lai, Zhenchang; Zhang, Yuwei; Liao, Chunyi; Huang, Minjie; (31 pag.)CN106317129; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

A common heterocyclic compound, the iron-catalyst compound, name is Ferrocene,cas is 102-54-5, mainly used in chemical industry, its synthesis route is as follows.

(1) Synthesis of ferrocene formaldehyde: under the protection of the helium gas, in the ice-bath cooling, constant pressure in the funnel 14.6 g (0.2 muM) DMF dimethyl formamide in 10 minutes into the 18.6 g (0.1 muM) ferrocene 75 ml dry chloroform solution; then, 30.6 g (0.2 muM) phosphorus oxychloride in a half-hour in dripped into the reaction bottle, the completion of the dropping, the oil bath temperature to 60 C, heating and stirring 20 hr, the oil bath temperature is still lower than the 60 C; the completion of the reaction, the reaction mixture is poured into ice water, the solid is most unreacted ferrocene, filtering to filter the solid insoluble matter, the filtrate magnesium carbonate powder carefully neutralized, then circulating extraction device repeatedly extraction reaction mixture, all of the extracts combined, water washing, the organic layer using sodium carbonate drying, to remove the solvent to obtain the crude product 18.21 g, dichloromethane is used for – hexane recrystallize to get red brown crystal 15.0 g, yield of 72.4%.

As the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Patent; Shandong Yuangen Petrochemical Co., Ltd.; Qiao Liang; Yuan Junzhou; Song Laigong; He Jingsong; Liu Shanshan; (7 pag.)CN104710482; (2018); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

A common heterocyclic compound, the iron-catalyst compound, name is Aminoferrocene,cas is 1273-82-1, mainly used in chemical industry, its synthesis route is as follows.

General procedure: Aminoferrocene (1, 11.0 mg, 0.0547 mmol) was dissolved in 9 cm3 toluene. Formylphenylboronic acid (2, 8.2 mg,0.0547 mmol) was dissolved in 1 cm3 dry ethanol. Both reagent solutions were mixed in an evaporating flask. The solvents were removed under reduced pressure on a rotary vacuum evaporator (the water bath temperature strictly below 40 C) to give [(ferrocenylimino)methyl]phenylboronic acid 3 as a violet/red powder; 18.2 mg (quant.). The products were used as prepared without need of a further purification (Fig. 5). 2-[(Ferrocenylimino)methyl]phenylboronic acid(3a, C17H16BFeNO2) 1H NMR (300.15 MHz, CD3OD): d = 4.30 (s, 5H Cp),4.44 (t, J = 2.0 Hz, 2H2[), 5.03 (t, J = 2.0 Hz, 2H3[),7.39 (d, J = 7.2 Hz, 1H5[), 7.51 (t, J = 6.5 Hz, 1H6[),7.56 (t, J = 7.0 Hz, 1H7[), 7.68 (d, J = 7.4 Hz, 1H8[),9.15 (s, 1H4[) ppm; 11B NMR (96.3 MHz, CD3OD):d = 13.55 ppm; 13C NMR (125.75 MHz, CD3OD):d = 63.26 (2C CpN), 67.55 (2C CpN), 69.88 (5C Cp),94.70 (Cipso CpN), 126.27 (Ar), 127.92 (Ar), 129.69 (Ar),131.84 (Ar), 138.92 (Ar), 162.50 (Cimino) ppm; ESI-MS2(40 eV): m/z (%) = 333.0574 (11) [M]?, 316.0553 (12),268.0197 (100), 250.0092 (21), 196.0906 (26), 133.0441(16); calcd. mass C17H16BFeNO2: m/z = 333.0624 [M]?; FT-IR (neat): m = 481, 758, 813, 999, 1104, 1246, 1336,1556, 1608, 2887, 2969, 3088, 3341 cm-1.

As the rapid development of chemical substances, we look forward to future research findings about 1273-82-1

Reference£º
Article; Konhefr, Martin; Lacina, Karel; Langmajerova, Monika Skrutkova; Glatz, Zden?k; Skladal, Petr; Mazal, Ctibor; Monatshefte fur Chemie; vol. 148; 11; (2017); p. 1953 – 1958;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12093-10-6,Ferrocenecarboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of KOH (12.0 equiv.)in absolute EtOH (100 mL) cooled to 0 C in an ice-bath were added dropwise a solution of thecorresponding acetophenone (1.0 equiv.) and aldehyde (1.0 equiv.) in EtOH (20 mL). The reactionmixture was stirred at 0 C for 1 h and then at room temperature for 72 h under a nitrogen atmosphereor until TLC analysis indicated complete consumption of starting material. The resulting mixture wasthen poured into ice-water (100 mL) and acidified to pH 3-4 with 3 M HCl. The aqueous solution wasextracted with CHCl3 (3 100 mL) and the combined organic layer was washed with satd NaHCO3(2 100 mL), brine (2 100 mL), dried over anhydrous MgSO4, filtered and the solvent removedunder reduced pressure. The crude residue was purified by flash column chromatography over silicaand/or recrystallized from MeOH or absolute EtOH to afford the corresponding chalcones.

As the paragraph descriping shows that 12093-10-6 is playing an increasingly important role.

Reference£º
Article; Sum, Tze Han; Sum, Tze Jing; Galloway, Warren R. J. D.; Collins, Suil; Twigg, David G.; Hollfelder, Florian; Spring, David R.; Molecules; vol. 21; 9; (2016);,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

102-54-5, Ferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ferrocene (0.500 g, 2.69 mmol) and acetic anhydride (1.7 mL) were dissolved in acid, phosphoric acid aqueous solution (85% in 0 oC, 0.53 g, were placed 0.30 mL, 4.8 mmol). After heating the reaction mixture under reflux for 15 minutes, it poured into a beaker containing 20 g of ice. After all the ice is melted were placed in a saturated aqueous solution of sodium bicarbonate until air bubbles are no longer generated. The reaction mixture was cooled to 0 dried under reduced pressure gave filtered while washing the resulting solid with water to give a red solid Compound 1b. (0.598 g, 97%).

As the paragraph descriping shows that 102-54-5 is playing an increasingly important role.

Reference£º
Patent; Diatech Korea Co. Ltd.; Sogang University Research Foundation; Moon, PongJin; Oh, HaNa; Kang, NaNa; Cheon, AeRan; Park, Gye Shin; Park, Hyeong Soon; Pang, Choo Young; (31 pag.)KR101583811; (2016); B1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

A common heterocyclic compound, the iron-catalyst compound, name is 1,1′-Dibromoferrocene,cas is 1293-65-8, mainly used in chemical industry, its synthesis route is as follows.

To a solution of 103 g (0.3 mol) of 1 ,1 ‘-dibromoferrocene in 300 ml of THF are added dropwise, at a temperature of < -300C, 120 ml (0.3 mol) of n-BuLi (2.5 M in hexane). The mixture is stirred at this temperature for a further 1.5 hour. The mixture is then cooled to -500C, and 66.2 ml (0.3 mol) of dicyclohexylphosphine chloride are added dropwise sufficiently slowly that the temperature does not rise above -45C. After stirring for a further 10 minutes, the temperature is allowed to rise to room temperature and the mixture is stirred for another hour. After 150 ml of water have been added, the reaction mixture is extracted by shaking with hexane. The organic phases are dried over sodium sulphate and the solvent is distilled off under reduced pressure on a rotary evaporator. The residue is crystallized in ethanol. The product A2 is obtained with a yield of 84% (yellow solid).31P NMR (121.5 MHz, C6D6): delta -8.3 (s); 1H NMR (300 MHz, C6D6): delta 4.41 (m, 2H), 4.26 (m, 2H), 4.23 (m, 2H), 3.97 (m, 2H), 1.20-2.11 (m, 22H).

As the rapid development of chemical substances, we look forward to future research findings about 1293-65-8

Reference£º
Patent; SOLVIAS AG; WO2009/65784; (2009); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1287-16-7, Ferrocenylacetic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of ferrocene acetic acid (1 mmol), the required 3-substituted-4-amino-5-mercapto-1,2,4-triazole(1 mmol), and p-toluenesulfonic acid (0.1 mmol) in DMF(10 mL) was stirred until a homogeneous solution was obtained. The mixture was exposed to microwave irradiation for about 3 min at 350 W and then cooled and poured into crushed ice. The mixture was adjusted to pH 7 with potassium carbonate and potassium hydroxide and then kept overnight at room temperature. The crude product was filtered off, dried and recrystallized from 80% ethanol to afford the pure product (Scheme 1). 6-Ferrocene methylene-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (1a) Brown solid; Yield: 82%; m.p.: 165-168 C; IR (KBr, nu/cm-1): 3085 (s), 2920 (m), 1604 (s), 656 (m), 487 (m); 1HNMR (CDCl3, 400 M, delta, ppm): 9.98 (s, 1H, N=CH), 4.30(s, 2H, C5H4),4.25 (s, 2H, C5H4),4.16 (s, 5H, C5H5),2.20(s, 2H, CH2);13C NMR (CDCl3, 100 M, delta, ppm): 167.6,161.0, 160.4, 137.2, 130.2, 121.3, 32.1; Anal. Cald. forC14H12N4SFe:C, 51.85; H, 3.70; N, 17.28; Found C, 51.68;H, 3.59; N, 17.51%.

As the paragraph descriping shows that 1287-16-7 is playing an increasingly important role.

Reference£º
Article; Liu, Yuting; Xin, Hong; Yin, Jingyi; Yin, Dawei; Transition Metal Chemistry; vol. 43; 5; (2018); p. 381 – 385;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

102-54-5, Ferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ferrocenecarboxaldehyde was prepared from ferrocene according to the literature.10 Phosphorus oxychloride (50mL, 536mmol) was added dropwise to the dimethylformamide (39.0g, 536mmol) at 0C and the resulting mixture was stirred for 30min at this temperature under a nitrogen atmosphere. Next ferrocene (50.0g, 268mmol) in dry chloroform (250mL) was added dropwise to the mixture for 30min at 0C. After completion of the addition, the reaction mixture was kept stirring for 28h with heating at 55-60C on an oil bath, taking care that the temperature did not exceed 60C. The reaction mixture was then cooled to room temperature and neutralized carefully with an aqueous saturated Na2CO3 solution and then extracted repeatedly with the dichloromethane. The combined organic layer was dried over anhydrous Na2SO4, filtered and the solvent was evaporated under reduced pressure. The residue was purified through silica gel column chromatography using hexane/ ethyl acetate mixture (95:05) as eluent to give ferrocenecarboxaldehyde 1 in 55% yield (31.7g) as a reddish brown solid. (mp: 122C, lit.10 123C); IR (KBr, cm-1): 3093, 2837, 2760, 1683, 1447; 1H NMR (400MHz, CDCl3): deltaH 9.95 (s, 1H); 4.80-4.60 (m, 4H), 4.27 (s, 5H); 13C NMR (100MHz, CDCl3): deltaC 193.63, 79.49, 73.33, 69.78; HRMS-ESI (m/z): [M+H]+ Found 215.0157 and calculated 215.0159 for C11H11FeO.

The synthetic route of 102-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Achari, Kamsali Murali Mohan; Ramanathan, Chinnasamy Ramaraj; Tetrahedron Asymmetry; vol. 28; 6; (2017); p. 830 – 836;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion