With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12093-10-6,Ferrocenecarboxaldehyde,as a common compound, the synthetic route is as follows.
General procedure: To a stirred solution of KOH (12.0 equiv.)in absolute EtOH (100 mL) cooled to 0 C in an ice-bath were added dropwise a solution of thecorresponding acetophenone (1.0 equiv.) and aldehyde (1.0 equiv.) in EtOH (20 mL). The reactionmixture was stirred at 0 C for 1 h and then at room temperature for 72 h under a nitrogen atmosphereor until TLC analysis indicated complete consumption of starting material. The resulting mixture wasthen poured into ice-water (100 mL) and acidified to pH 3-4 with 3 M HCl. The aqueous solution wasextracted with CHCl3 (3 100 mL) and the combined organic layer was washed with satd NaHCO3(2 100 mL), brine (2 100 mL), dried over anhydrous MgSO4, filtered and the solvent removedunder reduced pressure. The crude residue was purified by flash column chromatography over silicaand/or recrystallized from MeOH or absolute EtOH to afford the corresponding chalcones.
As the paragraph descriping shows that 12093-10-6 is playing an increasingly important role.
Reference£º
Article; Sum, Tze Han; Sum, Tze Jing; Galloway, Warren R. J. D.; Collins, Suil; Twigg, David G.; Hollfelder, Florian; Spring, David R.; Molecules; vol. 21; 9; (2016);,
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