Analyzing the synthesis route of 102-54-5

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocene,belong iron-catalyst compound

As a common heterocyclic compound, it belong iron-catalyst compound,Ferrocene,102-54-5,Molecular formula: C10Fe,mainly used in chemical industry, its synthesis route is as follows.,102-54-5

General procedure: A solution of acyl chloride (53.76 mmol) in 25 ml drydichloromethane was added to a suspension of anhydrousaluminum chloride (7.7 g, 53.76 mmol) in 25 ml drydichloromethane and the mixturewas stirred at 5 C for 1 hunder argon. The solution of aluminum chloride/acyl chloridecomplexwas added dropwise for 30 min to a solution offerrocene (10 g, 53.76 mmol) in 130ml dry dichloromethaneat 0 C. The reaction mixture was warmed to room temperatureand stirred for 16 h. A solution of NaBH4 (2.29 g,53.76 mmol) in 25 ml diglyme was added dropwise to thepurple reaction mixture at 5 C to form an orange solutionas the result which was stirred for an hour in 0 C. Themixture was hydrolyzed with water while maintaining itstemperature at less than or equal to 10 C. The mixture wasallowed to separate by settling and the organic phase wasthen withdrawn. The aqueous phase was extracted 3 timeswith 30 ml of CH2Cl2 and then all the organic phases werecombined,washed with 50 ml of brine, CH2Cl2was removedand the diglyme and the residual ferrocene which wasfound to be entrained by the diglyme, were distilled atreduced pressure of approximately 20 mm Hg at a columnhead temperature of 85 Ce95 C. The alkylferrocene derivativeswere distilled, at less than 5mmHg. Specific detailsare given for each compound.

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocene,belong iron-catalyst compound

Reference£º
Article; Teimuri-Mofrad, Reza; Mirzaei, Farzaneh; Abbasi, Hassan; D. Safa, Kazem; Comptes Rendus Chimie; vol. 20; 2; (2017); p. 197 – 205;,
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