Day: August 31, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.102-54-5,Ferrocene,as a common compound, the synthetic route is as follows.

1. Mix acetic anhydride and phosphoric acid and stir at room temperature for 15 minutes;2, adding ferrocene solids, heated to 40 C for 1 hour;3. Raise the temperature to 50 C and react until the ferrocene reaction is complete;4. The reaction solution is rapidly poured into crushed ice, and the pH is adjusted to 6 to 7 with sodium bicarbonate solids, and the crude acetylferrocene is obtained by filtration.5. Pure acetyl ferrocene is obtained by recrystallization from petroleum ether.In this example, acetic anhydride: phosphoric acid: ferrocene solids = 3:1:0.5.By elemental analysis tests, the product was confirmed to be acetylferrocene.The yield is above 95%.The reaction conditions for the synthesis of acetylferrocene are mild, the temperature is easy to control, and the preparation yield is high., 102-54-5

As the paragraph descriping shows that 102-54-5 is playing an increasingly important role.

Reference£º
Patent; Suzhou Tianyun Metal Materials Co., Ltd.; Wang Ming; (5 pag.)CN107488199; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1293-65-8,1,1′-Dibromoferrocene,as a common compound, the synthetic route is as follows.,1293-65-8

Example 1; L11,1′ bis-[(Sp,Rc,SFe)(1-N,N- Dimethylamino)ethylferrocenyl)phenylphosphino] ferrocene L1To a solution of (R)-N, N-dimethyl-1-ferrocenylethylamine [(R)-Ugi’s amine] (3.09 g, 12 mmol) in Et2O (20 ml) was added 1.5 M t-BuLi solution in pentane(8.0 ml, 12.0 mmol) at -78 0C. After addition was completed, the mixture was warmed to room temperature, and stirred for 1.5 h at room temperature. The mixture was then cooled to -78 0C again, and dichlorophenylphosphine (1.63 ml, 12.0 mmol) was added in one portion. After stirring for 20 min at -78 0C, the mixture was slowly warmed to room temperature, and stirred for 1.5 h at room temperature. The mixture was then cooled to -78 0C again, and a suspension of 1 ,1′ dilithioferrocene [prepared from 1 ,1′ dibromoferrocene(1.72 g, 5.0 mmol) and 1.5 M t-BuLi solution in pentane (14.0 ml, 21.0 mmol) in Et2O (20 ml) at -78 0C] was added slowly via a cannula. The mixture was warmed to room temperature and allowed to stir for 12 h. The reaction was quenched by the addition of saturated NaHCO3 solution (20 ml). The organic EPO layer was separated and dried over MgSO4 and the solvent removed under reduced pressure. The filtrate was concentrated. The residue was purified by chromatography (SiO2, hexane-EtOAc-Et3N = 85:10:5) to afford an orange solid (3.88 g, 85%) as a mixture of 95% his-(Sp,Rc,SFe) title compound L1 and 5% (Rp, Rc, S Fe-S p, Rc, S Fe) meso compound. The meso compound can be removed by further careful purification using chromatography (SiO2, hexane- EtOAc-Et3N = 85:10:5). Orange/yellow crystalline solid m.p. 190-192 0C. [alpha]D = -427 (c=0.005 (g/ml), toluene); 1H NMR (CDCI3, 400.13 MHz): delta 1.14 (d,6H,J = 6.7 Hz), 1.50 (s, 12H); 3.43 (m; 2H); 3.83 (m, 2H); 3.87 (m, 2H); 4.01 (s, 10H), 4.09 (t, 2H, J = 2.4 Hz); 4.11 (m, 2H); 4.20 (m, 2H); 4.28 (m, 2H); 4.61 (m, 2H); 4.42 (d, 2H1 J = 5.3 Hz); 7.18 (m, 6H); 7.42(m, 4H) ppm. 13C NMR (CDCI3, 100.61 MHz): delta 38.28, 57.40 (d, J = 5.6 Hz); 67.02, 69.04 (d, J = 4.0 Hz); 69.16 (d, J = 51.6 Hz); 69.66, 71.60 (d, J = 4.8 Hz), 71.91 (d, J = 7.2 Hz), 72.18 (d, J = 5.6 Hz), 75.96 (d, J = 35.7 Hz), 79.96 (d, J = 6.4 Hz), 95.73 (d, J = 19.1 Hz), 127.32 (d, J = 7.9 Hz), 127.62, 133.12 (d, J = 21.4 Hz), 139.73 (d, J = 4.0 Hz). 31P NMR (CDCI3, 162 MHz): delta -34.88 (s). Found: C, 65.53; H, 5.92; N 3.01 Calculated for C50H54Fe3N2P2; C, 65.81 ; H, 5.97; N, 3.07. HRMS (1OeV, ES+): Calcd for C50H55Fe3N2P2 [M+H]+: 913.1889; Found: 913.1952. The label SP refers to S configuration at phosphorus, Rc refers to R configuration at carbon (or other auxiliary) and Spe refers to S configuration at the planar chiral element.

1293-65-8 1,1′-Dibromoferrocene 72376387, airon-catalyst compound, is more and more widely used in various.

Reference£º
Patent; PHOENIX CHEMICALS LTD.; WO2006/75177; (2006); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

12093-10-6, Ferrocenecarboxaldehyde is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,12093-10-6

General procedure: To a stirred suspension of p-toluenesulfonyl hydrazide (1eq.) in water (12mL) and three drops of HCl 32%, the formyl or acetyl organometallic precursor (1eq.) was added. The resulting mixture was stirred for 18h at room temperature. The precipitate obtained was washed with water (2¡Á10mL) and dried under vacuum. The hydrazone derivatives were recrystallized from acetone/hexane (1:5) at -18C

12093-10-6 Ferrocenecarboxaldehyde 11138449, airon-catalyst compound, is more and more widely used in various.

Reference£º
Article; Concha, Camila; Quintana, Cristobal; Klahn, A. Hugo; Artigas, Vania; Fuentealba, Mauricio; Biot, Christophe; Halloum, Iman; Kremer, Laurent; Lopez, Rodrigo; Romanos, Javier; Huentupil, Yosselin; Arancibia, Rodrigo; Polyhedron; vol. 131; (2017); p. 40 – 45;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-82-1, Aminoferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Aminoferrocene (1, 11.0 mg, 0.0547 mmol) was dissolved in 9 cm3 toluene. Formylphenylboronic acid (2, 8.2 mg,0.0547 mmol) was dissolved in 1 cm3 dry ethanol. Both reagent solutions were mixed in an evaporating flask. The solvents were removed under reduced pressure on a rotary vacuum evaporator (the water bath temperature strictly below 40 C) to give [(ferrocenylimino)methyl]phenylboronic acid 3 as a violet/red powder; 18.2 mg (quant.). The products were used as prepared without need of a further purification (Fig. 5)., 1273-82-1

As the paragraph descriping shows that 1273-82-1 is playing an increasingly important role.

Reference£º
Article; Konhefr, Martin; Lacina, Karel; Langmajerova, Monika Skrutkova; Glatz, Zden?k; Skladal, Petr; Mazal, Ctibor; Monatshefte fur Chemie; vol. 148; 11; (2017); p. 1953 – 1958;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-82-1,Aminoferrocene,as a common compound, the synthetic route is as follows.,1273-82-1

Triphosgene (1.61 g, 5,44 mmol) and aminoferrocen (1.09 g, 5.44 mmol) were added to toluene (98 mL) and purged with argon. The mixture was heated up to 120 C and kept at this temperature until all starting materials were dissolved (~30 min). The solution obtained was cooled down to 22 C and 4-(hydroxymethyl)-2-methylphenylboronic acid pinacol ester (1.35 g, 5.44 mmol) dissolved in CH2Cl2 (132 mL) was added dropwise. The solution was left stirring at 22 C for 44 h. Then, the solvent was removed in vacuum (10 mbar) and the product was purified by column chromatography on silica gel using hexane / EtOAc (10/2, v/v) as eluent. Yield 0.83 g (32 %). Rf= 0.33 (silica, eluent – CH2Cl2 / EtOAc, 7/2, v/v). 1H NMR (200 MHz, acetone-d6), delta in ppm: 7.72 (d, 1 H), 7.21 (m, 2H), 5.12 (s, 2H), 4.56 (s, 2H), 4.11 (s, 5H), 3.93 (s, 2H), 2.52 (t, 3H),1.34 (s, 12H). 13C NMR (100.55 MHz, acetone-d6), delta in ppm: 145.8, 141.0, 137.0, 129.7, 124.7, 84.3, 69.8, 66.5, 64.7, 61.1, 25.3, 22.5. FAB MS: calculated for C25H30BFeNO4 475.2, found 475.2 m/z. C, H, N analysis: calculated for C25H30BFeNO4 – C 63.2 %; H 6.4 %; N 3.0 %; found – C 63.3 %; H 6.6 %; N2.9%.

The synthetic route of 1273-82-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ruprecht-Karls-Universitaet Heidelberg; EP2497775; (2012); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.102-54-5,Ferrocene,as a common compound, the synthetic route is as follows.,102-54-5

In a three-necked flask equipped with a thermometer, 3.72 g (0.02 mol) of ferrocene and 18.86 mL (0.2 mol) of acetic anhydride were added 3.3 mL (0.06 mol) of phosphoric acid was added dropwise with stirring. The temperature was controlled at 55-60C and the TLC point plate was followed to complete conversion of ferrocene. After adding saturated Na2CO3 solution to neutralize to pH=7, the mixture was extracted with methylene chloride (30 mL x 3) and the combined organic phases were washed with water and dried over anhydrous magnesium sulfate. Column separation. 3.86 g of pure acetylferrocene was obtained. Yield : 85%.

102-54-5 Ferrocene 7611, airon-catalyst compound, is more and more widely used in various.

Reference£º
Patent; Zhengzhou University of Light Industry; Yu Shuyan; Zhang Tongyan; Wang Ruijuan; Yin Zhigang; Yang Xuzhao; Lan Hongbing; (13 pag.)CN107383112; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

12126-50-0, Bis(pentamethylcyclopentadienyl)iron(II) is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,12126-50-0

A yellow-orange solution of decamethylferrocene(16 mg, 0.05 mmol) in CH2Cl2(0.1 mL) was placed in a test tube (5 mm inner diameter),and a colorless solution of Ph(Cl)C=C(Ph)TeCl3 (22 mg, 0.05 mmol) in CH2Cl2 (0.2 mL)was carefully added dropwise. The contact areabetween the solutions acquired a green color typical ofthe ferrocenium cation, but no precipitation or formationof solid particles was observed in the contact area.The test tube was purged with argon, sealed with severalparafilm layers, and left in the dark at room temperature.After 5 days, the solvent evaporated almostcompletely and uniform green prismatic crystals, suitablefor X-ray diffraction, were deposited on the tubewall.

12126-50-0 Bis(pentamethylcyclopentadienyl)iron(II) 22218084, airon-catalyst compound, is more and more widely used in various.

Reference£º
Article; Torubaev, Yu. V.; Lyssenko; Popova; Russian Journal of Coordination Chemistry; vol. 45; 11; (2019); p. 788 – 794; Koord. Khim.; vol. 45; 11; (2019); p. 684 – 690,7;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-82-1,Aminoferrocene,as a common compound, the synthetic route is as follows.,1273-82-1

To a mixture of methyl4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (100 mg, 0.410 mmoL), ferrocenylamine(114 mg, 0.410 mmoL), and p-toluenesulfonic acid monohydrate (15 mg, 0.082 mmoL) was addedanhydrous 1,4-dioxane (1 mL) under an argon atmosphere. The resulting mixture was heated to 150 Cunder microwave irradiation and stirred for 30 min. The resulting mixture was concentrated underreduced pressure. The resulting residue was purified by column chromatography (n-hexane/ethylacetate, 100:00¡À40:60). The appropriate fractions were combined and concentrated under reducedpressure to give methyl-5-methyl-4-(ferrocenylamino)thieno[2,3-d]pyrimidine-6-carboxylate (2) asan orange solid (105 mg, 63%). 1H NMR (d6-DMSO, 500 MHz): = 8.53 (1H, s), 8.02 (1H, s),4.82 (2H, s), 4.16 (5H, s), 4.07 (2H, s), 3.84 (3H, s), 3.02 (3H, s). 13C NMR (d6-DMSO, 126 MHz): = 171.0, 153.5, 130.1, 125.4, 125.3, 124.3, 124.1, 96.1, 79.8, 69.2, 64.1, 61.1, 36.2, 28.7. HRMS-ESI (m/z):calc. for [C19H17FeN3O2S + H]+ = 407.2712, observed = 407.2716. Anal. Calc. (%) for C19H17FeN3O2S:C, 56.03; H, 4.21; N, 10.32. Found (%): C, 55.97; H, 4.19; N, 10.21.

The synthetic route of 1273-82-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sansook, Supojjanee; Lineham, Ella; Hassell-Hart, Storm; Tizzard, Graham J.; Coles, Simon J.; Spencer, John; Morley, Simon J.; Molecules; vol. 23; 9; (2018);,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

12093-10-6, Ferrocenecarboxaldehyde is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

An ethanolic solution (10 ml) of ferrocenyl carboxyaldehyde (21 mg, 0.1 mmol) was taken in a round bottomed flask and acetyl cymantrene (28 mg, 0.1 mmol) was added under stirring condition. Two equivalents of sodium hydroxide in ethanol solution was then added to the reaction mixture and stirring was continued at room temperature under inert atmosphere for 3 h. The reaction was continuously monitored by TLC and on completion of the reaction the solution was dried under vacuum and the residue was dissolved in dichloromethane solvent and subjected to chromatographic work-up using column chromatography. Elution with dichloromethane/hexane (30:70 v/v) solvent mixture separated the following compounds in the order of elution: [(CO)3Mn(eta5-C5H4)COCH3], [(eta5-C5H5)Fe(eta5-C5H4CHO)] and violet colored compound [(eta5-C5H4)Mn(CO)3COCH=CH(eta5-C5H4)Fe(eta5-C5H5)] (1). {Yield: 32 mg (73%)} 1: Anal. calcd. (found): C, 57.01 (57.23); H, 3.39 (3.34). IR(nuCO, cm-1,CH2Cl2) 2022.8 (vs), 1937 (vs br), 1653 (s), 1586 (s). 1H NMR (delta, CDCl3): 4.2 (s, eta5-C5H5, 5H), 4.52 (t, eta5-C5H4, 2H), 4.6 (t, eta5-C5H4, 2H), 4.9 (t, eta5-C5H4, 2H), 5.55 (t, eta5-C5H4, 2H), 6.58 (d, J = 15 Hz, CH=, 1H), 7.78 (d, J = 15 Hz, =CH, 1H). 13C NMR (delta, CDCl3): 69.16 (eta5-C5H5), 69.95 (eta5-C5H4), 71.66 (eta5-C5H4), 78.47 (eta5-C5H4), 83.61 (eta5-C5H4), 86.59 (eta5-C5H4), 93.78 (eta5-C5H4), 117.41 (=CH), 146.38 (=CH), 185.29 (-C=O). UV-Vis. (lambda (nm), CH2Cl2) = 321, 384, 502. MS (ESI): m/z 443 (M + 1)+., 12093-10-6

As the paragraph descriping shows that 12093-10-6 is playing an increasingly important role.

Reference£º
Article; Mishra, Sasmita; Tirkey, Vijaylakshmi; Ghosh, Avishek; Dash, Hirak R.; Das, Surajit; Shukla, Madhulata; Saha, Satyen; Mobin, Sheikh M.; Chatterjee, Saurav; Journal of Molecular Structure; vol. 1085; (2015); p. 162 – 172;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.102-54-5,Ferrocene,as a common compound, the synthetic route is as follows.,102-54-5

A 250 mL round bottom reaction flask was charged sequentially with 1.46 g of aluminum trichloride (11 mmol) and 20 mL of dichloroethane,Under ice-water cooling, 0.8 mL of acetyl chloride (11 mmol)Continue stirring until almost dissolved aluminum trichloride.In another 250 mL round bottom reaction flask,A solution of 1.86 g (ie 10 mmol) of ferrocene in dichloroethane was added,Under ice-cooling, the acetyl chloride-aluminum trichloride complex solution prepared above was dropped,Stirring to complete the reaction at room temperature (monitored by thin layer chromatography) takes about 2 hours.The reaction was poured into ice water,Separate the organic phase,Followed by water,5% sodium carbonate solution and water,Drying over anhydrous sodium sulfate.The solvent was removed under reduced pressure,A red oil was obtained,Recrystallization to give orange crystals of acetyl ferrocene,Yield 80%.

As the paragraph descriping shows that 102-54-5 is playing an increasingly important role.

Reference£º
Patent; Inner Mongolia University; Zhang Hao; Ling Li; Hu Jianfeng; Huo Yanhong; (11 pag.)CN107226829; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion