Month: August 2020

1271-42-7, Ferrocenecarboxylic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0120] Ferrocene (6.0 g, 32 mmol) and potassium tert-butoxide (0.46 g, 4.08 mmol) were completely dissolved in dryTHF (300 mL). The orange solution was cooled to -78C when tert-butyllithium (34.0 mL, 64.5 mmol, 1.9 M in pentane)was added dropwise over a period of 15 min, with the temperature maintained below -70C. The reaction mixture wasstirred at -78C for 1 h and then poured on a slurry of dry ice (excess) and diethyl ether. The mixture was warmed toroom temperature overnight and extracted with an aqueous solution of sodium hydroxide (0.75 N, 4 x 250 mL). Thecombined aqueous layers were neutralized with hydrochloric acid (pH > 4) and the resulting orange solid was extractedwith Et2O (4 x 250 mL) until the organic layer remained colourless. The combined organic layers were filtered to removetraces of ferrocenedicarboxylic acid, dried over MgSO4, filtered and the solvent was evaporated under reduced pressureto give ferrocenecarboxylic acidas an orange solid in 35% yield. After suspending the ferrocenecarboxylic acid (462 mg,2.01 mmol) in dry CH2Cl2 (23 mL), oxalyl chloride (1100 mL, 13.64 mmol) in dry CH2Cl2 (10 mL) was added dropwiseto the reaction mixture whereby the orange suspension turned dark red. The reaction mixture was refluxed for 2 h andthen stirred overnight at room temperature. The solvent was then removed under vacuum. The product was not purifiedand used immediately for the next synthetic step.

The synthetic route of 1271-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Universitaet Zuerich; The University of Melbourne; Gasser, Gilles; Gasser, Robin B.; Hess, Jeannine; Patra, Malay; Jabbar, Abdul; EP2821412; (2015); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1293-65-8, 1,1′-Dibromoferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a Schlenk flask (10 mL) equipped with a magnetic stir bar, 1,1′-dibromoferrocene (120 mg, 34.9 mumol) and THF (0.53 mL) were placed. A pentane solution of t-BuLi (0.88 mL, 1.6 M, 1.4 mmol) was dropwise added to the solution at -50 C and the resulting mixture was stirred at below -30 C for 1 h. Then, a THF suspension (3.5 mL) of compound 4 (448 mg, 704 mumol) was added to the resulting yellow suspension at -50 C and stirred at ambient temperature. After 0.5 h, the reaction mixture was quenched with water and the crude mixture was extracted with hexane. The organic layer was dried over anhydrous sodium sulfate. After removal of the resulting salt by filtration and the solvent in vacuo, the residue was subjected to silica gel column chromatography (eluent: hexane) and gel permeation chromatography (eluent: toluene). Recrystallization from hexane gave the title compound (50.8 mg, 39.2 mumol, 11%) as yellow crystals.

The synthetic route of 1293-65-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kishimoto, Yusuke; Ishida, Shintaro; Iwamoto, Takeaki; Chemistry Letters; vol. 45; 2; (2016); p. 235 – 237;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1287-16-7,Ferrocenylacetic acid,as a common compound, the synthetic route is as follows.

Under ice cooling, 0.57 mL (4 mmols) of triethylamine was added to a mixture of 0.5 g (2 mmols) of ferroceneacetic acid (manufactured by Tokyo Kasei Kogyo Co., Ltd.), 0.44 mL (2 mmols) of diphenylphosphyrylazide and 4 mL of toluene. The mixture was stirred at room temperature for 30 minutes. The reaction mixture was diluted with dichloromethane. The dilution was washed sequentially with a 1% hydrochloric acid aqueous solution and saturated sodium hydrogencarbonate solution. After drying over anhydrous magnesium sulfate, the organic layer was filtered and concentrated under reduced pressure to give 4 mL of the toluene solution. To the toluene solution obtained, 2 mL of toluene was added and 0.32 g (3 mmols) of ethyl carbazate was added to the mixture while stirring at room temperature. The mixture was then heated under reflux for 3 hours and diluted with dichloromethane. The dilution was washed sequentially with a 1% hydrochloric acid aqueous solution and saturated sodium hydrogencarbonate solution. After drying over anhydrous magnesium sulfate, the organic layer was filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (chloroform : methanol = 20:1) to give 0.55 g (78%) of ethyl 3-(ferrocenylmethyl)carbamoylcarbazate as a yellow oily substance. 1H NMR (CDCl3) delta: 1.27 (3H, t, J=7.3 Hz), 4.0-4.3 (13H, m), 5.59 (1H, m), 6.59 (1H, s), 6.66 (1H, s)

The synthetic route of 1287-16-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP1533316; (2005); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-51-8, Vinylferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A deoxygenated mixture of vinylferrocene (636 mg, 3.0 mmol), K2CO3 (5.52 g, 40 mmol), tetrabutylammonium bromide (4.51 g, 14 mmol), pseudo-para dibromo-[2.2]-paracyclophane [61] (366.1 mg, 1.0 mmol) and Pd(OAc)2 (67 mg, 0.3 mmol) in DMF (43 mL) was heated at 95 ¡ãC for 20 h. After cooling to r.t. the dark reaction mixture was filtered, diluted with CH2Cl2 (~40 mL) and washed with brine (4 x 30 mL). The organic phase was dried with MgSO4, filtered and the solvent was removed from the filtrate in vacuo. The residuewas subjected to chromatography on deactivated Al2O3 (n-hexane). Two fractions containing productswere collected: a first one containing 3 (270 mg, 31percent) and a second one containing 2. Slightly impure 2was again subjected to columnchromatography on silica gel with CHCl3 followed by crystallization from a CHCl3/MeOH mixture. 2 was obtained as an orange solid in a yield of 245 mg, 39percent.

The synthetic route of 1271-51-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Short Survey; Mu?cke, Philipp; Winter, Rainer F.; Kowalski, Konrad; Journal of Organometallic Chemistry; vol. 735; (2013); p. 10 – 14;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of K2CO3 (1 mmol) and the catalyst (52 mg, ?3 mol% of Pd2+) in toluene (5 ml) was prepared in a two necked flask. The flask was evacuated and refilled with pure oxygen. To this solution, the alcohol (1 mmol, in 1 ml toluene) was injected and the resulting mixture was stirred at 80 C under an oxygen atmosphere. After completion of reaction, the reaction mixture was filtered off and the catalyst rinsed twice with CH2Cl2 (5 ml). The excess of solvent was removed under reduced pressure to give the corresponding carbonyl compounds.

1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various.

Reference£º
Article; Alizadeh; Khodaei; Kordestania; Beygzadeh; Journal of Molecular Catalysis A: Chemical; vol. 372; (2013); p. 167 – 174;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1287-16-7,Ferrocenylacetic acid,as a common compound, the synthetic route is as follows.

General procedure: A mixture of ferrocene acetic acid (1 mmol), the required 3-substituted-4-amino-5-mercapto-1,2,4-triazole(1 mmol), and p-toluenesulfonic acid (0.1 mmol) in DMF(10 mL) was stirred until a homogeneous solution was obtained. The mixture was exposed to microwave irradiation for about 3 min at 350 W and then cooled and poured into crushed ice. The mixture was adjusted to pH 7 with potassium carbonate and potassium hydroxide and then kept overnight at room temperature. The crude product was filtered off, dried and recrystallized from 80% ethanol to afford the pure product (Scheme 1).

1287-16-7 Ferrocenylacetic acid 73425372, airon-catalyst compound, is more and more widely used in various.

Reference£º
Article; Liu, Yuting; Xin, Hong; Yin, Jingyi; Yin, Dawei; Transition Metal Chemistry; vol. 43; 5; (2018); p. 381 – 385;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

Compound hydroxymethylferrocene S5 (1 g, 4.63 mmol),1-chloro-3,5-di-p-chlorobenzoyloxy-2-deOxygen-D-ribose S6 (1.79 g, 4.17 mmol),Anhydrous Cs2CO3 (2.60 g, 7.87 mmol) was dissolved in anhydrous dichloromethane.Stir at room temperature overnight, and vortex off the solvent.Silica gel column chromatography(Dichloromethane: methanol = 95:5) was purified to give an orange-red compound S7 (yield: 80%).

As the paragraph descriping shows that 1273-86-5 is playing an increasingly important role.

Reference£º
Patent; Hunan University; Tan Weihong; A Budula¡¤lazhate¡¤moyideng; (23 pag.)CN109265486; (2019); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-82-1, Aminoferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 300 mg (1.5 mmol) of the amine ferrocene obtained in Preparation Example 1, 1.8 g (4.5 mmol) of 4′-bromo-N, N-diphenylbiphenyl-4-amine (4′-bromo- -diphenylbiphenyl-4-amine),17 mg (0.075 mmol) of palladium acetate [Pd (OAc) 2]0.1 mL of a 10 wt% tributylphosphine n-hexane solution and 1.13 g (11.8 mmol) of sodium tert-butoxide(NaOtBu)And with 6 mL of toluene as solvent,After reacting at 130 C for 72 hours,The palladium catalyst was first removed by filtration through diatomaceous earth and silica gel,And rinsed with ethyl acetate to remove the solvent,And finally purified by column chromatography [4: 1 to 3: 2 (v / v) n-hexane and ethyl acetate gradient stripping system]To obtain the compound DPABPAFc (yield 50%The structure is shown in Reaction Scheme III).

1273-82-1 Aminoferrocene 72747180, airon-catalyst compound, is more and more widely used in various.

Reference£º
Patent; Zheng, Jianhong; Lai, Zhenchang; Zhang, Yuwei; Liao, Chunyi; Huang, Minjie; (31 pag.)CN106317129; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

14024-18-1, Iron(III) acetylacetonate is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Fe(acac)3 (176.5 mg), 1,2-hexadecanediol (645 mg), oleic acid (0.5 mL), oleylamine (0.5 mL), and octadecene (10 mL) were mixed and magnetically stirred under a flow of nitrogen. The mixture was heated to 200 C. for 30 min and then, under a blanket of nitrogen, heated to reflux (?300 C.) for another 30 min. The black-brown mixture was cooled to room temperature by removing the heat source. Under ambient conditions, ethanol (40 mL) was added to the mixture, and a black material was precipitated and separated via centrifugation. The product, Fe3O4 nanoparticles, was redispersed into hexane for storage.

14024-18-1 Iron(III) acetylacetonate 91759530, airon-catalyst compound, is more and more widely used in various.

Reference£º
Patent; Hong Kong Baptist University; YUNG, Kin Lam; LUI, Nga Ping; TSANG, Shik Chi; PENG, Yung Kang; US2015/335767; (2015); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1293-65-8, 1,1′-Dibromoferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

120 ml (0.3 mol) of n-BuLi (2.5 M in hexane) are added dropwise at a temperature of <-30C to a solution of 103 g (0.3 mol) of 1 ,1 '-dibromoferrocene in 300 ml of THF. The mixture is stirred further at this temperature for 1.5 hours. The mixture is then cooled to -500C, and 66.2 ml (0.3 mol) of dicyclohexylphosphine chloride are slowly added dropwise at such a rate that the temperature does not rise above -45C. After stirring for a further 10 minutes, the temperature is allowed to rise to room temperature and the mixture is stirred for another one hour. After adding 150 ml of water, the reaction mixture is extracted by shaking with hexane. The organic phases are dried over sodium sulphate, and the solvent is distilled off under reduced pressure on a rotary evaporator. The residue is crystallized in ethanol. The product 13 is obtained with a yield of 84% (yellow solid). 1H NMR (300 MHz, C6D6): delta 1.20-2.11 (m, 22H), 3.97 (m, 2H), 4.23 (m, 2H), 4.26 (m, 2H), 4.41 (m, 2H). 31P NMR (121.5 MHz, C6D6): delta -8.3 (s). The synthetic route of 1293-65-8 has been constantly updated, and we look forward to future research findings. Reference£º
Patent; Solvias AG; WO2007/135179; (2007); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion