With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12093-10-6,Ferrocenecarboxaldehyde,as a common compound, the synthetic route is as follows.,12093-10-6
General procedure: The ferrocenecarboxaldehyde (2.0mmol) and the acetyl pyridine or amino acetophenone derivatives (2.0mmol) were added to a round bottom flask at rt. Then, a freshly prepared NaOH solution (0.5mmol in 1.0 mL each of H2O and EtOH) was added dropwise and left stirring at rt. When completed, the resulting product was filtered at reduced pressure, washing with cold water. The crude product was then recrystallized as described. Compound 2a: 3-ferrocenyl-1-(2-pyridinyl) prop-2-en-1-one was obtained as dark violet crystals after recrystallization using acetone:H2O mixture. Yield: 0.41g (64%) of pure product. 1H NMR (500MHz, CDCl3): delta=8.73 (s, 1H), 8.18 (d, J=7Hz, 1H), 7.89 (s, 1H), 7.86 (d, J=4Hz, 2H), 7.46 (s, 1H), 4.67 (s, 2H), 4.49 (s, 2H), 4.18 (s, 5H). 13C NMR (125MHz, CDCl3): delta=188.5, 154.7, 148.8, 147.2, 137.0, 126.5, 122.9, 117.8, 79.5, 71.5, 69.9, 69.5. FT-IR (neat) numax (cm-1): 1659 (m), 1591 (m), 1574 (w), 1462 (w), 1396 (m).
The synthetic route of 12093-10-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Delgado-Rivera, Sara M.; Perez-Ortiz, Giovanny E.; Molina-Villarino, Andres; Morales-Fontan, Fabiel; Garcia-Santos, Lyannis M.; Gonzalez-Albo, Alma M.; Guadalupe, Ana R.; Montes-Gonzalez, Ingrid; Inorganica Chimica Acta; vol. 468; (2017); p. 245 – 251;,
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