Name is Ferrocene, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 102-54-5, its synthesis route is as follows.,102-54-5
General procedure: A solution 3-5mmol of ferrocene in dichloromethane (DCM) or dichloroethane (DCE) (3-5mL) was prepared. A previously prepared solution of 1equivalent of acyl chloride and 1equivalent of aluminum chloride in DCM or DCE (3-5mL) was transferred to the ferrocene solution, while stirring and with positive nitrogen pressure. The mix of the two liquids generated an intense purple or blue mixture. Reaction was stopped after 30-60min of stirring at room temperature. An equal quantity of water was added to the reaction mixture. The organic phase was separated and the aqueous phase was extracted with methyl t-butyl ether (MTBE), and the combined organic phase was dried over anhydrous sodium sulfate. The solvent was removed and the crude product (red to orange solid) was purified by column chromatography column on silica gel (230-400mesh) with a gradient of cyclohexane-benzene as eluent.
With the complex challenges of chemical substances, we look forward to future research findings about Ferrocene
Reference£º
Article; Garcia-Barrantes, Pedro M.; Lamoureux, Guy V.; Perez, Alice L.; Garcia-Sanchez, Rory N.; Martinez, Antonio R.; San Feliciano, Arturo; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 548 – 557;,
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