Day: September 27, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 1.0mmol of ferrocene alcohol and 1.0mmol of the corresponding nitroimidazole in 1.0ml of methylene dichloride, 0.18ml of 45% aqueous solution of fluoroboric acid was added under vigorous stirring. The agitation was continued for 5min then diethyl ether (15ml), the same amount of cold water, and 5-10mg of ascorbic acid were added to the reaction flask. After vigorous shaking of the mixture, the organic solution was separated, washed with cold water (3¡Á15ml), the solvents were removed in vacuo, and the residue was dried over CaCl2 in a desiccator.

1273-86-5, 1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Snegur, Lubov V.; Lyapunova, Maria V.; Verina, Daria D.; Kachala, Vadim V.; Korlyukov, Alexander A.; Ilyin, Mikhail M.; Davankov, Vadim A.; Ostrovskaya, Larissa A.; Bluchterova, Natalia V.; Fomina, Margarita M.; Malkov, Victor S.; Nevskaya, Kseniya V.; Pershina, Alexandra G.; Simenel, Alexander A.; Journal of Organometallic Chemistry; vol. 871; (2018); p. 10 – 20;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

The iron-catalyst compound, cas is 1271-51-8 name is Vinylferrocene, mainly used in chemical industry, its synthesis route is as follows.,1271-51-8

General procedure: A deoxygenated mixture of vinylferrocene (170mg, 0.80mmol), K2CO3 (1.50g, 11mmol), tetrabutylammonium bromide (1.19g, 3.70mmol), bromochromone (0.66mmol) and Pd(OAc)2 (20mg, 0.09mmol) in DMF (23ml) was heated at 95¡ãC for 19h. After cooling to r. t. the reaction mixture was evaporated to dryness. Solid residue was dissolved in chloroform and extracted several times with water. The organic phase was dried with MgSO4, filtered and the solvent was removed from the filtrate in vacuo. The residue was subjected to chromatography on SiO2 (eluent: CHCl3/methanol, 50:2). Finally the analytically pure products were obtained after recrystallization from chloroform/n-hexane mixture.

As the rapid development of chemical substances, we look forward to future research findings about 1271-51-8

Reference£º
Article; Kowalski, Konrad; Koceva-Chy, Aneta; Szczupak, Lukasz; Hikisz, Pawel; Bernasin?ska, Joanna; Rajnisz, Aleksandra; Solecka, Jolanta; Therrien, Bruno; Journal of Organometallic Chemistry; vol. 741-742; 1; (2013); p. 153 – 161;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

The iron-catalyst compound, cas is 1271-42-7 name is Ferrocenecarboxylic acid, mainly used in chemical industry, its synthesis route is as follows.,1271-42-7

Chlorocarbonyl ferrocene 2b: The synthesis of chlorocarbonyl ferrocene 2b was adapted from a procedure of Cormode et al. {Dalton Trans. 2010, 39, 6532). After suspending ferrocenecarboxylic acid 2a (462 mg, 2.01 mmol) in dry CH2CI2 (23 mL), oxalyl chloride (1 100 mu, 13.64 mmol) in dry CH2CI2 (10 mL) was added dropwise to the reaction mixture whereby the orange suspension turned dark red. The reaction mixture was refluxed for 2 h and then stirred overnight at room temperature. The solvent was then removed under vacuum. The product 2 was not purified and used immediately for the next synthetic step.

With the rapid development of chemical substances, we look forward to future research findings about 1271-42-7

Reference£º
Patent; UNIVERSITAeT ZUeRICH; THE UNIVERSITY OF MELBOURNE; GASSER, Gilles; GASSER, Robin B.; HESS, Jeannine; JABBAR, Abdul; PATRA, Malay; WO2015/44395; (2015); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

Ferrocene methanol (ferrocenyl methanol, 3mmol), triphenylphosphine (PPh3,1.18g, 4.5mmol), all-trans retinoic acid (ATRA, 3mmol), was dissolved in 20mL of tetrahydrofuran (THF), stir to dissolve, then under nitrogen, was added diisopropyl azodicarboxylate (DIAD, 0.8g, 4.5mmol) under conditions of 0 C . The reaction Thin chromatography (TLC) monitoring process, after the completion of the reaction continued at room temperature for 2 hours. 30 deg C and concentrated in vacuo by rotary evaporation to a thick oil, the product was extracted using silica gel column chromatography (ethyl acetate / petroleum ether = 2: 8 volume ratio) to give the product as the first ferrocene carboxylic acid (FCRA ), 83% yield

1273-86-5, As the paragraph descriping shows that 1273-86-5 is playing an increasingly important role.

Reference£º
Patent; Jilin University; SUN, HONGCHEN; SUN, BIN; ZHU, SHOUJUN; WANG, DANDAN; ZHANG, KAI; LI, XING; WANG, LU; WANG, YIBO; TANG, QI; XIN, YING; YANG, BAI; (13 pag.)CN106265600; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-42-7,Ferrocenecarboxylic acid,as a common compound, the synthetic route is as follows.

In a three-necked flask, 4.6 g (0.02 mmol) of dry ferrocenecarboxylic acid and 80 mL of anhydrous benzene were added.Under nitrogen protection,6.24 g (0.03 mmol) of phosphorus pentachloride was slowly added in several portions, and stirred at room temperature for 3 h.The benzene is distilled off under reduced pressure, and petroleum ether (60-90 C) is extracted to obtain a deep red solution, distilled under reduced pressure, and cooled.Dark red needle crystals are precipitated, yield 80%

1271-42-7, 1271-42-7 Ferrocenecarboxylic acid 499634, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Guilin Medical University; Huang Wanyun; Liao Ying; Peng Xiangyan; Yin Penglong; Liao Yueying; (13 pag.)CN104788503; (2017); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Vinylferrocene, cas is 1271-51-8, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-51-8

Under argon, into a dried reactor were added successively vinyl ferrocene (1mol, 212g), (R ) -3,3′-bis (3,5-dimethylphenyl) -1,1 ‘ – binaphthol phosphonate (0.01mol, 5.6g) and 1L of toluene, followed by addition of di-tert-butylphosphine (1mol, 147g), heated to 60 deg.] C for 12 hours, then cooled cooling, water was added dropwise to the system, and then liquid separation, the organic layer was dried over anhydrous magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to give a yellow solid which was recrystallized from dichloromethane and methanol to give (R) -1- ferrocenyl ethyl-di-tert-butylphosphine 347g yield 97percent, ee value of 99.5percent.

With the rapid development of chemical substances, we look forward to future research findings about 1271-51-8

Reference£º
Patent; Institute of Chemistry, Henan Academy of Sciences; Chen, Hui; Yang, Ruina; Yang, Zhenqiang; Sun, Minqing; Duan, Zheng; Wang, Congyang; (5 pag.)CN105859800; (2016); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Acetylferrocene, cas is 1271-55-2, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-55-2

To a solution of 172 mg KOH (3.07 mmol) in 10 cm3 of EtOH/H2O (1:1) at r.t., 1 g of acetylferrocene(4.38 mmol) was added, followed by dropwise addition of 0.45 cm3 benzaldehyde (4.38 mmol). The thus prepared darkviolet solution was stirred at r.t. for 3 days. Then the reaction mixture was extracted with CH2Cl2(3 ¡Á 10 cm3). The collected organic layers were dried over Na2SO4 and filtered,and the resulting solution was evaporated under reduced pressure to afford the crude product. Isolated enone 9 was characterized and used in the subsequent reaction without further purification. Dark-red crystalline solid (1.28 g, yield:93%); m.p.: 112-118 C; 1H NMR (600 MHz, CDCl3):delta = 7.81 (d, J = 15.7 Hz, 1H), 7.68-7.63 (m, 2H), 7.45-7.39(m, 3H), 7.14 (d, J = 15.6 Hz, 1H), 4.92-4.91 (m, 2H),4.61-4.57 (m, 2H), 4.21 (s, 5H) ppm; 13C NMR (150 MHz,CDCl3):delta = 192.8, 140.8, 135.1, 130.1, 128.9, 122.9, 80.6,72.7, 70.1, 69.7, 69.7 ppm; IR (neat): = 1648 (s, C=O),1595 (m, C=C), 1456 (m, C-H), 1376 (m, C-H), 1280 (w,C-H), 1079 (m, C-H), 993 (w, C-H), 821 (m, C-H), 757(m, C-H), 687 (m, C-H), 544 (w, C-H), 499 (s, C-H), 480 (s, C-H) cm-1; HRMS (ESI): m/z found 317.0621, calcd forC19H17FeO+([M + H+]) 317.0629.

With the rapid development of chemical substances, we look forward to future research findings about 1271-55-2

Reference£º
Article; Mravec, Bernard; Plevova, Kristina; ?ebesta, Radovan; Monatshefte fur Chemie; vol. 150; 2; (2019); p. 295 – 302;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.

General procedure: As shown as the synthetic protocol A in Scheme 2, compounds 1-11 were synthesized following literature description [16] with m-methoxyphenol, p-methoxyphenol, resorcinol, and hydroquinone as reagents. One hydroxyl group in resorcinol and hydroquinone was protected by tert-butyldimethylsilyl chloride. Then, 17 mL of dry CHCl3 solution containing excess PhtNSCl was added dropwisely to 8 mL of dry CHCl3 solution containing monoprotected hydroquinone or resorcinol and stirred for 16 h at 0 ¡ãC until phenols cannot be detected by thin layer chromatography (TLC). The mixture was diluted with CH2Cl2 and washed by saturated NaHCO3 and water. The organic phase was dried over anhydrous Na2SO4, and the solvent was removed under vacuum. The residue was purified by column chromatography with CH2Cl2 as the eluent to afford thiophthalimides as colorless solid. The following cycloaddition reactions were carried out in dry CHCl3 solution of thiophthalimides (~ 0.1 M) and styrenes (2 equiv.) or vinyl ferrocene (2 equiv.) and freshly distilled (C2H5)3N (2 equiv.) at 60 ¡ãC. The reaction was finished with thiophthalimides not detected by TLC. Then, the solvent was evaporated under vacuum pressure, and the residual solid was purified with column chromatography to afford silylated adducts. The desilylation operation was performed in dry tetrahydrofuran (THF) solution containing 0.04 M aforementioned adducts at 0 ¡ãC, to which a solution of (n-C4H9)4NF*3H2O in THF (1 equiv. for each protective group) was added. The reaction was finished with the reagent not detected by TLC, and then the mixture was diluted with ethyl acetate and washed with saturated NH4Cl and water. The organic layer was dried over anhydrous Na2SO4, and the solvent was evaporated under vacuum pressure. The residue was purified with column chromatography to afford thiaflavans.

1271-51-8, 1271-51-8 Vinylferrocene 16211828, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Lai, Hai-Wang; Liu, Zai-Qun; European Journal of Medicinal Chemistry; vol. 81; (2014); p. 227 – 236;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-55-2, Acetylferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 1.14 g (5 mmol) of acetylferrocene, 5 mmol of the corresponding aromatic aldehyde, 50 mL of ethanol, and 2.5 g (45 mmol) of potassium hydroxide was stirred for 12 h at room temperature. The mixture was poured onto ice, and the precipitate was filtered off and purified by silica gel column chromatography using methylene chloride (2, 4) or methylene chloride-hexane (19 : 1) (3) as eluent. 1-Ferrocenyl-3-(4-fluorophenyl)prop-2-en-1-one(2). Yield 85%,

1271-55-2, 1271-55-2 Acetylferrocene 79159, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Antuf?eva; Zhulanov; Dmitriev; Mokrushin; Shklyaeva; Abashev; Russian Journal of General Chemistry; vol. 87; 3; (2017); p. 470 – 478; Zh. Obshch. Khim.; vol. 87; 3; (2017); p. 465 – 473,9;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-42-7, Ferrocenecarboxylic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 50mL three necks round bottom flask and under nitrogen atmosphere, 1mmol of ferrocenecarboxylic acid was dissolved in 15mL of dry dichloromethane at room temperature. To this solution, 170-200muL of oxalyl chloride was added dropwise and stirred overnight. The solution changed from orange to dark red. The reaction mixture was filtered in a fritted funnel and the filtrate collected. In a separate 100mL three necks round flask under nitrogen, 1.0mmol of the 4-X-phenol and 1.0mmol of pyridine were dissolved in 10-15mL of dichloromethane. To this solution, the ferrocenecarbonyl chloride solution prepared previously was added dropwise. The solution was stir 6-12hin the dark, under nitrogen atmosphere, and at room temperature. Thin layer chromatography (TLC) was used to monitor the reaction. After the reaction was finished, the mixture was filtered in a fritted funnel with a pad of celite. The filtrate collected was washed with 3¡Á5mL 1N HCl to remove pyridine and other by-products. The organic layer containing the compound was purified by column chromatography, using Silica gel and eluted with dichloromethane and isolated in 40-45% yield.

1271-42-7, 1271-42-7 Ferrocenecarboxylic acid 499634, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Vera, Jose L.; Rullan, Jorge; Santos, Natasha; Jimenez, Jesus; Rivera, Joshua; Santana, Alberto; Briggs, Jon; Rheingold, Arnold L.; Matta, Jaime; Melendez, Enrique; Journal of Organometallic Chemistry; vol. 749; (2014); p. 204 – 214;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion