With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-42-7,Ferrocenecarboxylic acid,as a common compound, the synthetic route is as follows.
Ferrocene (6.0 g, 32 mmol) and potassium tert-butoxide (0.46 g, 4.08 mmol) were completely dissolved in dry THF (300 mL). The orange solution was cooled to -78 0C when tertbutyllithium (34.0 mL, 64.5 mmol, 1 .9 M in pentane) was added dropwise over a period of 15 mm, with the temperature maintained below -70 00. The reaction mixture was stirred at -78Cfor 1 h and then poured on a slurry of dry ice (excess) and diethyl ether. The mixture was warmed to room temperature overnight and extracted with an aqueous solution of sodium hydroxide (0.75 N, 4 x 250 mL). The combined aqueous layers were neutralized with hydrochloric acid (pH > 4) and the resulting orange solid was extracted with Et20 (4 x 250 mL) until the organic layer remained colourless. The combined organic layers were filtered toremove traces of ferrocenedicarboxylic acid, dried over MgSO4, filtered and the solvent wasevaporated under reduced pressure to give ferrocenecarboxylic acidas an orange solid in35% yield. After suspending the ferrocenecarboxylic acid (462 mg, 2.01 mmol) in dry CH2CI2(23 mL), oxalyl chloride (1100 iL, 13.64 mmol) in dry CH2CI2 (10 mL) was added dropwise tothe reaction mixture whereby the orange suspension turned dark red. The reaction mixturewas refluxed for 2 h and then stirred overnight at room temperature. The solvent was thenremoved under vacuum. The product was not purified and used immediately for the next synthetic step.
1271-42-7, As the paragraph descriping shows that 1271-42-7 is playing an increasingly important role.
Reference£º
Patent; UNIVERSITAeT ZUeRICH; THE UNIVERSITY OF MELBOURNE; HESS, Jeannine; PATRA, Malay; GASSER, Gilles; JABBAR, Abdul; GASSER, Robin B.; WO2015/928; (2015); A1;,
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