Day: October 13, 2020

1271-42-7, Ferrocenecarboxylic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of ferrocene carboxylic acid (2.3 g, 10 mmol) in dry dichloromethane (20 ml.) was treated with oxalyl chloride dropwise (1.8 ml_, 20 mmol) at 0 C under nitrogen with the addition of four drops of DMF. The reaction mixture was returned to r.t. and stirred for 3 hours. The solvent and the excess oxalyl chloride was removed under nitrogen, and the resulting red solid was redissolved to fresh dry dichloromethane (20 ml_). Tetrabutylammoniun bromide (12 mg, 0.03 mmol) was added followed by the addition of a NaN3 solution (1 g, 15 mmol) in water (5 ml_). The reaction mixture was stirred under nitrogen and at r.t for a further 18 h. The reaction was quenched by the addition of water (50 ml.) and the organic phase was separated, and the aqueous was further extracted with dichloromethane (2 x 20 ml_). The combined organic phase was washed with brine, dried with Na2S04 and the solvent was removed under vacuum. The desired azide was isolated by flash column chromatography eluting with dichloromethane:hexane (1 :1 ). Yield: 78%. NMR (CDCIs, ppm): 1H (500 MHz) 4.78, 4.55, 4.05; 13C (126 MHz) 176.1 , 89.0, 76.3, 78.0, 80.1.

1271-42-7, The synthetic route of 1271-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NATIONAL CENTRE FOR SCIENTIFIC RESEARCH “DEMOKRITOS”; PELECANOU ZAMPARA, Maria; SAGNOU, Marina; PAPADOPOULOS, Minas; PIRMETTIS, Ioannis; MAVROIDI, Barbara; SHEGANI, Antonio; (38 pag.)WO2019/180200; (2019); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5

General procedure: To a mixture of 1.0mmol of ferrocene alcohol and 1.0mmol of the corresponding nitroimidazole in 1.0ml of methylene dichloride, 0.18ml of 45% aqueous solution of fluoroboric acid was added under vigorous stirring. The agitation was continued for 5min then diethyl ether (15ml), the same amount of cold water, and 5-10mg of ascorbic acid were added to the reaction flask. After vigorous shaking of the mixture, the organic solution was separated, washed with cold water (3¡Á15ml), the solvents were removed in vacuo, and the residue was dried over CaCl2 in a desiccator.

With the rapid development of chemical substances, we look forward to future research findings about Ferrocenemethanol

Reference£º
Article; Snegur, Lubov V.; Lyapunova, Maria V.; Verina, Daria D.; Kachala, Vadim V.; Korlyukov, Alexander A.; Ilyin, Mikhail M.; Davankov, Vadim A.; Ostrovskaya, Larissa A.; Bluchterova, Natalia V.; Fomina, Margarita M.; Malkov, Victor S.; Nevskaya, Kseniya V.; Pershina, Alexandra G.; Simenel, Alexander A.; Journal of Organometallic Chemistry; vol. 871; (2018); p. 10 – 20;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-42-7,Ferrocenecarboxylic acid,as a common compound, the synthetic route is as follows.

Ferrocenecarboxylicacid 46 (500 mg, 2.2 mmol) wasstirred with oxalyl chloride (634 mg, 5.0 mmol) for 1 h. The evaporationresidue, in dry THF (5.0 mL), was added dropwise to saturated NH3 inEt2O (25 mL). After 15 min, H2O (20 mL) was added andorganic layer was washed thrice (H2O). Drying and evaporationgave ferrocenecarboxamide (370 mg, 74%) as a pale orange solid: mp 168-169C(lit.10 mp 168-171C); 1H NMR ((CD3)2SO)d 4.15 (5 H, s, Fc?-H5), 4.32 (2 H, br, Fc3,4-H2), 4.74 (2 H, br, Fc 2,5-H2), 6.91 (1 H, br, NH),7.28 (1 H, br, NH); 13C NMR ((CD3)2SO)(HSQC / HMBC) d 68.49 (Fc 2,5-C2),69.31 (Fc?-C5), 69.91 (Fc 3,4-C2), 76.42 (Fc 1-C), 171.01(C=O). This material (352 mg, 1.5 mmol) was stirred with POCl3 (3.5mL) at 120C for 2 h, followed by cooling to 0C and quench with H2O(1.0 mL). The mixture was diluted with EtOAc and washed thrice with H2O.Drying and evaporation gave 47 (360mg, 99%) as a dark orange solid: mp 105-107C (lit.11 mp 106-106.5C); 1HNMR ((CD3)2SO) d 4.34(5 H, s, Fc?-H5), 4.50 (2 H, s, Fc 3,4-H2), 4.83 (2 H, s,Fc 2,5-H2); 13C NMR ((CD3)2SO)(HSQC / HMBC) d 51.05 (Fc 1-C),70.32 (Fc?-C5), 71.00 (Fc 3,4-C2), 71.61 (Fc 2,5-C2),120.21 (CN).

1271-42-7, The synthetic route of 1271-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Paine, Helen A.; Nathubhai, Amit; Woon, Esther C.Y.; Sunderland, Peter T.; Wood, Pauline J.; Mahon, Mary F.; Lloyd, Matthew D.; Thompson, Andrew S.; Haikarainen, Teemu; Narwal, Mohit; Lehtioe, Lari; Threadgill, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5891 – 5908;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Vinylferrocene, cas is 1271-51-8, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-51-8

General procedure: A stirred mixture of bromo compound (1.0 equiv.), Pd(OAc)2 (0.1/0.2 equiv.) in dry DMF (25mL) under nitrogen was successively treatedwith K2CO3 (3.0/6.0 equiv.) and tetrabutylammoniumbromide (0.1/0.2equiv.)and stirred for 30 min. The vinyl dendron (1.0/2.0 equiv.)wasthen added and the resulting mixture was stirred at 90 ¡ãC for 12 h,cooled and filtered. The filtrate was evaporated to dryness in vacuo.The residue was extracted with CHCl3 (3 ¡Á 100 mL), washed withwater (3 ¡Á 100 mL) and dried over anhydrous Na2SO4. Evaporation ofthe organic layer afforded the crude product,whichwas purified by columnchromatography using the eluent as mentioned under each compoundto afford the corresponding conjugated dendrimers.

With the rapid development of chemical substances, we look forward to future research findings about Vinylferrocene

Reference£º
Article; Ravivarma, Mahalingam; Kumar, Kaliamurthy Ashok; Rajakumar, Perumal; Pandurangan, Arumugam; Journal of Molecular Liquids; vol. 265; (2018); p. 717 – 726;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5

Acetophenone (120mg, 1mmol), cat.1 (5.4mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol,0.1equiv.), Ferrocene methanol (238mg, 1.1mmol) and tert-amyl alcohol (1ml) were sequentially added to 5mL round bottom flask.After the reaction mixture was refluxed in air for six hours, cooled to room temperature. The solvent is removed by rotary evaporation, then purified by column chromatography (developingOpen solvent: petroleum ether / ethyl acetate) to give pure target compound, yield: 82%

With the rapid development of chemical substances, we look forward to future research findings about Ferrocenemethanol

Reference£º
Patent; Nanjing University of Science and Technology; Ma, Juan; Li, Lei; Li, Feng; (17 pag.)CN105439787; (2016); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 10 ml Schlek reaction tube under a high-purity nitrogen atmosphere was added 0.20 mmol of benzoquinoline triphenylphosphine iridium hydrogen (16), lmmol of phenylacetylene, 2.3 mmol of ferrocene methanol, 0.8 mmol of sodium hydroxide and 3 ml of dioxane were charged. The reaction tube was replaced with nitrogen three times and then heated to 110 C with an oil bath under magnetic stirring. The reaction was refluxed for 36 hours. The filtrate was concentrated using a rotary evaporator and the remaining residue was purified by chromatography on oil (100 mL). The residue was purified by flash chromatography on silica gel eluting with an oil bath and the bath was cooled to room temperature. Ether as eluent, and separated by silica gel thin layer chromatography to obtain pure product 1-ferrocenyl-3-phenyl-1-propanone in a yield of 96%.

1273-86-5, 1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Luoyang Normal University; Li, Xiao Dong; Li, gongmei; Xu, Chen; Hao, Xin Qi; Xiao, Zhi Qiang; (10 pag.)CN103242372; (2016); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14024-18-1,Iron(III) acetylacetonate,as a common compound, the synthetic route is as follows.

The magnetic nanoparticles were synthesized according to a previously reported procedure26. Briefly, a solution of Fe(acac)3 (5.65 g, 0.016 mol), benzyl ether (80 mL) and oleylamine (80 mL) was heated to 110 C and allowed to reflux for 1 h with vigorous stirring. The temperature was raised to 210 C and then refluxed for 2 h under an argon atmosphere. After cooling to room temperature, the reaction mixture was centrifuged at 10,000 rpm for 20 min, affording the magnetic nanoparticles (Fe3O4) as a black solid. The magnetic nanoparticles were then dispersed in a mixture of 1-propanol (180 mL), conc. NH4OH (25 mL) and deionized water (18 mL) in a 500 mL round-bottom flask by ultra-sonication for 30 min under an argon atmosphere. Following this, tetraethylorthosilicate (TEOS) (6 mL, 0.027 mol) was added dropwise for 30 min with vigorous stirring. After stirring at room temperature for 6 h, thesilica-coated magnetic nanoparticles (Fe3O4(at)SiO2) were separated from the solution using an external magnet and then washed twice successively with 1-propanol and deionized water, respectively. The Fe3O4(at)SiO2 nanoparticles (brown solid) were then dried under vacuum at 60 C for 6 h, prior to use., 14024-18-1

14024-18-1 Iron(III) acetylacetonate 91759530, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Wechakorn, Kanokorn; Chanpanich, Pairsunan; Kamkalong, Pimfa; Anantachisilp, Suranan; Oriental Journal of Chemistry; vol. 35; 3; (2019); p. 1054 – 1061;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-42-7, Ferrocenecarboxylic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. Ferrocenecarboxylic acid (11.5 g, 0.05 mol) was mixed with 100 mL of dichloromethane (DCM) under ice bath and stirred well.N-hydroxysuccinimide (NHS) (7.0 g, 0.06 mol) was added to the above reaction system under vigorous stirring.1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC¡¤HCl) (11.5 g, 0.06 mol).The reaction was carried out for 4 to 6 hours in an ice bath, the solution was gradually clarified, and the reaction was monitored by TLC.After completion of the reaction, suction filtration was performed to obtain a dichloromethane solution of the intermediate (1).

1271-42-7, The synthetic route of 1271-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong University; Yan Bing; Pan Xiujiao; Jiang Cuijuan; Wang Shenqing; Kong Long; Zhai Shumei; Hu Chun; Zhou Li; (17 pag.)CN109288860; (2019); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenecarboxylic acid, cas is 1271-42-7, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-42-7

To a suspension of ferrocenylcarboxylic acid (60 mg, 0.26 mmol,3 equiv) in 1 mL of dry CH2Cl2 was added at room temperatureoxalyl chloride (225 mL, 2.65 mmol, 27 equiv). After 30 min at roomtemperature, the solution took a deep red color. The mixture wasconcentrated in vaccuo to remove excess oxalyl chloride. Podophyllotoxin(38 mg, 90 mmol, 1 equiv) was solubilizedequiv in1.5 mL of dry CH2Cl2 and Et3N (15 mL, 0.11 mmol, 1.2 equiv) wasadded. To this mixture was added at 0 C ferrocenoyl chloride in2 mL of CH2Cl2. Then a few crystals of DMAP were added and themixture was stirred at 0 C for 30 min and at room temperature for1 h. Reaction was quenched by addition of water, extracted withCH2Cl2 (3), washed with diluted HCl (~0.1 N), dried over MgSO4and concentrated under vacuum. The crude product was purifiedby preparative TLC on silica (AcOEt/Cyclohexane 2/3) to yield 35 mgof the desired compound as an orange powder (60%). 1H NMR(400 MHz, CDCl3): delta (ppm) 6.90 (s, 1H), 6.58 (s, 1H), 6.44 (s, 2H),6.04-5.97 (m, 3H), 4.85 (dt, J = 2.5, 1.3 Hz, 1H), 4.81 (dt, J= 2.5,1.3 Hz, 1H), 4.64 (d, J= 4.3 Hz, 1H) 4.50-4.44 (m, 3H), 4.30 (m, 1H),4.25 (s, 5H), 3.81 (s, 3H), 3.80 (s, 6H), 3.02e2.87 (m, 2H). 13C NMR(101 MHz, CDCl3): delta (ppm) 173.8, 172.6, 152.8, 148.3, 147,8, 137.4,135.1, 132.5, 129.0, 109.9, 108.4, 107.1, 101.8, 73.5, 72.1, 72.0, 71.8,70.4, 70.3, 70.0, 61.0, 56.3, 45.8, 43.9, 39.1. IR (neat, cm-1): 1780,1711, 1485, 1240, 1128. Exact mass (C33H30FeO9): calculated649.1132 (M +Na)+, measured 649.1121.

As the rapid development of chemical substances, we look forward to future research findings about 1271-42-7

Reference£º
Article; Beauperin, Matthieu; Polat, Dilan; Roudesly, Fares; Top, Siden; Vessieres, Anne; Oble, Julie; Jaouen, Gerard; Poli, Giovanni; Journal of Organometallic Chemistry; vol. 839; (2017); p. 83 – 90;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14024-18-1,Iron(III) acetylacetonate,as a common compound, the synthetic route is as follows.

Fe(acac)3 (3 mmol) was dissolved in 20 ml of oleylamine and 5 ml of n-hexane. The reaction mixture was thoroughly stirred under N2 atmosphere for 30 min in a 50 ml Teflon-lined stainless steel autoclave that was carefully sealed. The autoclave was heated in a furnace at 190 C for 8 h under autogenous pressure. The resulting dark suspensions were extracted by adding 50 ml of ethanol followed by centrifugation. After washing the precipitates three times with ethanol, uniform Fe3O4 NPs were formed. These NPs were redispersed into n-hexane and a black-brown n-hexane dispersion of Fe3O4 NPs was thus obtained. Thus, the Fe3O4 suspension was transferred to 100 ml volumetric flask, evenly mixed with n-hexane for measurement of concentration of Fe3O4 through the 1,10-phenanthroline monohydrate dyeing method using UV-Vis spectrophotometer. Similar procedures for the preparation of Fe3O4 NPs were carried out at different conditions, including different reaction temperatures, times, and solvents. The solvothermal temperatures for samples S1 and S3 differed from that for S2. For samples S4-S6, the reaction times differed from that of S2. For samples S7-S9, the content of n-hexane differed from that of sample S2. The detailed preparation conditions are listed in Table 1 .

14024-18-1, 14024-18-1 Iron(III) acetylacetonate 91759530, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Jing; Wang, Lu; Wang, Jing; Zhang, Lantong; Materials Research Bulletin; vol. 48; 2; (2013); p. 416 – 421;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion