As a common heterocyclic compound, it belong iron-catalyst compound,Ferrocenemethanol,1273-86-5,Molecular formula: C11H3FeO,mainly used in chemical industry, its synthesis route is as follows.,1273-86-5
The cyanuric chloride (TCT)(0.184 g, 1 mmol) and 30 mL of dry tetrahydrofuran were added to a 100 mL round bottom flask,To a stirred solution of 20 mL of ferrocene methanol (0.864 g, 4 mmol) Of the dry tetrahydrofuran solution was slowly added dropwise to the reaction system.After stirring for 30 minutes under ice bath, 10 mL of a solution containing DMAP (0.366 g, 3 mmol)In a dry tetrahydrofuran solution was slowly added dropwise to the reaction system, and the mixture was stirred at room temperature for 5 minutes after stirring for 30 minutes. After the reaction was carried out at room temperature for 5 to 6 hours, the reaction was refluxed. After completion of the reaction, the reaction solution was concentrated under reduced pressure,The residue was separated by column chromatography using (V petroleum ether: V ethyl acetate, 5: 1-2: 1)The mobile phase was eluted to give nitroxyl radical containing ferrocene derivative I, 0.506 g, yield: 70%.
With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenemethanol,belong iron-catalyst compound
Reference£º
Patent; Xiamen Xitu Materials Institute; Yong Jianping; Lu Canzhong; (9 pag.)CN104804047; (2017); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
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