With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.
Under argon, into a dried reactor were added successively vinyl ferrocene (1mol, 212g), (R ) -3,3′-bis (3,5-dimethylphenyl) -1,1 ‘ – binaphthol phosphonate (0.01mol, 5.6g) and 1L of toluene, followed by addition of di-tert-butylphosphine (1mol, 147g), heated to 60 deg.] C for 12 hours, then cooled cooling, water was added dropwise to the system, and then liquid separation, the organic layer was dried over anhydrous magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to give a yellow solid which was recrystallized from dichloromethane and methanol to give (R) -1- ferrocenyl ethyl-di-tert-butylphosphine 347g yield 97percent, ee value of 99.5percent.
1271-51-8, 1271-51-8 Vinylferrocene 16211828, airon-catalyst compound, is more and more widely used in various fields.
Reference£º
Patent; Institute of Chemistry, Henan Academy of Sciences; Chen, Hui; Yang, Ruina; Yang, Zhenqiang; Sun, Minqing; Duan, Zheng; Wang, Congyang; (5 pag.)CN105859800; (2016); A;,
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