Ferrocenemethanol, cas is 1273-86-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1273-86-5
The benzonitrile (103mg, 1mmol), [(IPr) AuNTf] (17mg, 0.02mmol, 2mol%),tetrahydrofuran (0.5ml), H 2O (0.5ml) were successively added to the reaction flask25mlSchlenk. After the mixture was reacted at 130 C at 12 hours, cooled to roomtemperature, the solvent was removed in vacuo under reduced pressure. The [Cp * IrCl 2]2(8mg, 0.01mmol, 1mol%), ferrocene methanol (260mg, 1.2mmol), cesium carbonate (65mg,0.2equiv.) And toluene (1ml) was added to the reaction flask and the reaction mixturewas continued at 130 C at 12 hours, cooled to room temperature. The solvent was removedrotary evaporation, then purified by column chromatography (developing solvent: ethylacetate / petroleum ether) to give pure title compound Yield: 83%.
With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenemethanol,belong iron-catalyst compound
Reference£º
Patent; Nanjing University of Science and Technology; Ma, Juan; Wang, Na Na; Li, Feng; (16 pag.)CN105820061; (2016); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion