As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO379,mainly used in chemical industry, its synthesis route is as follows.,1271-55-2
General procedure: A solution of pure TsNHNH2 (15 mmol) in methanol (30 mL) was stirred and heated to 60 C until the TsNHNH2 dissolved. The mixture was cooled to room temperature. Then a solution of ferrocenylketone (10 mmol) in methanol was dropped into the mixture slowly. After approximately 0.5-2 h, the crude products could be obtained as solid precipitate. The precipitate was washed with petroleum ether then removed in vacuo to give the pure products. In general, the yields were 68-86 %. Because of the relatively low activity of some ketones, their reactions at room temperature may be incomplete. They should be reacted in refluxing methanol. The reaction could be monitored by TLC.
With the synthetic route has been constantly updated, we look forward to future research findings about Acetylferrocene,belong iron-catalyst compound
Reference£º
Article; Ling, Li; Hu, Jianfeng; Huo, Yanhong; Zhang, Hao; Tetrahedron; vol. 73; 1; (2017); p. 86 – 97;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion