With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.
To a solution of ferrocenylmethanol (1.62 g, 7.5 mmol) in dry THF (15mL), NaH (0.45 g) were added slowly at 0 C. After stirring for 0.5 h,1-bromo-4-(bromomethyl)benzene (1.88 g, 7.5 mmol) in THF (10 mL) wasadded dropwise and the reaction mixture was stirred overnight at 60 C. Thereaction mixture was quenched with saturated aq. NH4Cl (50 mL) at 0 C andextracted with CH2Cl2. The organic extracts were washed with brine, dried overanhydrous Na2SO4 and concentrated under reduced pressure. The residue waspurified by column chromatography to afford a yellow solid (2.25 g, 78%). 1HNMR (CDCl3, 400 Hz, delta/ppm) 7.47 (dt, J1 = 8.4 Hz, J2 = 2 Hz, 2H,), 7.21 (d, J= 8.4 Hz, 2H), 4.45 (s, 2H), 4.32 (s, 2H), 4.24 (t, J = 1.6 Hz, 2H), 4.17 (t, J =1.6 Hz, 2H), 4.12 (s, 5H); 13C NMR (CDCl3, 100 Hz, delta/ppm) 137.6, 131.4,129.3, 121.3, 83.1, 70.8, 69.4, 68.6, 68.5, 68.4.
1273-86-5, 1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various fields.
Reference£º
Article; Meng, Zhengong; Wei, Zhuoxun; Fu, Kuo; Lv, Lei; Yu, Zhen-Qiang; Wong, Wai-Yeung; Journal of Organometallic Chemistry; vol. 892; (2019); p. 83 – 88;,
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