Day: October 30, 2020

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenecarboxylic acid, and cas is 1271-42-7, its synthesis route is as follows.,1271-42-7

Ferrocene (6.0 g, 32 mmol) and potassium tert-butoxide (0.46 g, 4.08 mmol) were completely dissolved in dry THF (300 mL). The orange solution was cooled to -78 0C when tertbutyllithium (34.0 mL, 64.5 mmol, 1 .9 M in pentane) was added dropwise over a period of 15 mm, with the temperature maintained below -70 00. The reaction mixture was stirred at -78Cfor 1 h and then poured on a slurry of dry ice (excess) and diethyl ether. The mixture was warmed to room temperature overnight and extracted with an aqueous solution of sodium hydroxide (0.75 N, 4 x 250 mL). The combined aqueous layers were neutralized with hydrochloric acid (pH > 4) and the resulting orange solid was extracted with Et20 (4 x 250 mL) until the organic layer remained colourless. The combined organic layers were filtered toremove traces of ferrocenedicarboxylic acid, dried over MgSO4, filtered and the solvent wasevaporated under reduced pressure to give ferrocenecarboxylic acidas an orange solid in35% yield. After suspending the ferrocenecarboxylic acid (462 mg, 2.01 mmol) in dry CH2CI2(23 mL), oxalyl chloride (1100 iL, 13.64 mmol) in dry CH2CI2 (10 mL) was added dropwise tothe reaction mixture whereby the orange suspension turned dark red. The reaction mixturewas refluxed for 2 h and then stirred overnight at room temperature. The solvent was thenremoved under vacuum. The product was not purified and used immediately for the next synthetic step.

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenecarboxylic acid

Reference£º
Patent; UNIVERSITAeT ZUeRICH; THE UNIVERSITY OF MELBOURNE; HESS, Jeannine; PATRA, Malay; GASSER, Gilles; JABBAR, Abdul; GASSER, Robin B.; WO2015/928; (2015); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Vinylferrocene, cas is 1271-51-8, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-51-8

A deoxygenated mixture of vinylferrocene (170mg, 0.80mmol), K2CO3 (1.50g, 11mmol), tetrabutylammonium bromide (1.19g, 3.70mmol), 6-bromochromone-3-propionic acid (196.8mg, 0.66mmol) and Pd(OAc)2 (20mg, 0.09mmol) in DMF (23ml) was heated at 95¡ãC for 19h. After cooling to r. t. the reaction mixture was evaporated to dryness. Solid residue was dissolved in chloroform and extracted six times with water followed by extraction with 3.5percent HClaq. The organic phase was dried with MgSO4, filtered and the solvent was removed from the filtrate in vacuo. The residue was subjected to chromatography on SiO2 (eluent: CHCl3/methanol, 50:5). Finally the analytically pure products were obtained after recrystallization from DMSO/water.

1271-51-8 is used more and more widely, we look forward to future research findings about Vinylferrocene

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Article; Kowalski, Konrad; Koceva-Chy, Aneta; Szczupak, Lukasz; Hikisz, Pawel; Bernasin?ska, Joanna; Rajnisz, Aleksandra; Solecka, Jolanta; Therrien, Bruno; Journal of Organometallic Chemistry; vol. 741-742; 1; (2013); p. 153 – 161;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ferrocenemethanol (1.3 mmol), 4-methylaniline (1 mmol), carbon-supported ruthenium nanomaterial (20 mg),Potassium hydroxide (20 mg) was added to a 25 ml reaction tube with a magnetic stirrer.After repeated nitrogen suction three times, toluene (3 ml) was added via a syringe and then sealed and reacted at 110C for 24 hours.After the reaction is completed, the catalyst is removed by filtration, and the filtrate is extracted by adding water and ethyl acetate, and the organic phases are combined.After drying, filtration, concentration under reduced pressure, and silica gel column chromatography, N-(ferrocenyl)aniline (yield 85%) was obtained., 1273-86-5

As the paragraph descriping shows that 1273-86-5 is playing an increasingly important role.

Reference£º
Patent; Soochow University (Suzhou); Li Hongxi; Guo Bin; Lang Jianping; (16 pag.)CN107954879; (2018); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenecarboxylic acid, cas is 1271-42-7, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-42-7

Compound 15 was reacted with tert-butoxide, t-BuLi and 002 yielding compound 3a. The synthesis of ferrocenecarboxylic acid 3a (step a) was adapted from a procedure from Witte et al. (Organometallics 1999, 18, 4147). Compound 3a was reacted with oxalyl chloride under reflux yielding compound 3b. The synthesis of chlorocarbonyl ferrocene 3b (step b) was adapted from a procedure of Cormode et al. (Dalton Trans.201 0, 39, 6532). Optionally anadapted procedure of Lorkowski et. al. (VIII. Preparation of monomeric and polymeric ferrocenylene oxadiazoles, J. Prakt. Chem. 1967, 35, 149-58) may be applied. Chlorocarbonyl ferrocene 3b and 2-amino-2-hydroxymethylproprionitrile 6 were dissolved in dry THF and Triethylamine was added (step c). After evaporation of the solvent and purification by column chromatography N-(2-cyano-1-hydroxypropan-2-yl)ferroceneamide 7a was isolated in 29% yield according to an adapted procedure of Gasser et al. (J. Organomet.Chem. 2010, 695, 249-255). Compound 7a was reacted with one equivalent of 5a in thepresence of K2003 and 18-crown-6 in dry CH3CN according to an adapted procedure ofGasser et al. (J. Organomet. Chem. 2007, 692, 3835-3840) and Gasser et al. (J. Med.Chem. 2012, 55, 8790-8798), yielding compound 1 in a yield of 43%.

As the rapid development of chemical substances, we look forward to future research findings about 1271-42-7

Reference£º
Patent; UNIVERSITAeT ZUeRICH; THE UNIVERSITY OF MELBOURNE; GASSER, Gilles; GASSER, Robin B.; HESS, Jeannine; JABBAR, Abdul; PATRA, Malay; WO2015/44396; (2015); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Name is Vinylferrocene, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1271-51-8, its synthesis route is as follows.,1271-51-8

General procedure: As shown as the synthetic protocol A in Scheme 2, compounds 1-11 were synthesized following literature description [16] with m-methoxyphenol, p-methoxyphenol, resorcinol, and hydroquinone as reagents. One hydroxyl group in resorcinol and hydroquinone was protected by tert-butyldimethylsilyl chloride. Then, 17 mL of dry CHCl3 solution containing excess PhtNSCl was added dropwisely to 8 mL of dry CHCl3 solution containing monoprotected hydroquinone or resorcinol and stirred for 16 h at 0 ¡ãC until phenols cannot be detected by thin layer chromatography (TLC). The mixture was diluted with CH2Cl2 and washed by saturated NaHCO3 and water. The organic phase was dried over anhydrous Na2SO4, and the solvent was removed under vacuum. The residue was purified by column chromatography with CH2Cl2 as the eluent to afford thiophthalimides as colorless solid. The following cycloaddition reactions were carried out in dry CHCl3 solution of thiophthalimides (~ 0.1 M) and styrenes (2 equiv.) or vinyl ferrocene (2 equiv.) and freshly distilled (C2H5)3N (2 equiv.) at 60 ¡ãC. The reaction was finished with thiophthalimides not detected by TLC. Then, the solvent was evaporated under vacuum pressure, and the residual solid was purified with column chromatography to afford silylated adducts. The desilylation operation was performed in dry tetrahydrofuran (THF) solution containing 0.04 M aforementioned adducts at 0 ¡ãC, to which a solution of (n-C4H9)4NF*3H2O in THF (1 equiv. for each protective group) was added. The reaction was finished with the reagent not detected by TLC, and then the mixture was diluted with ethyl acetate and washed with saturated NH4Cl and water. The organic layer was dried over anhydrous Na2SO4, and the solvent was evaporated under vacuum pressure. The residue was purified with column chromatography to afford thiaflavans.

With the complex challenges of chemical substances, we look forward to future research findings about Vinylferrocene

Reference£º
Article; Lai, Hai-Wang; Liu, Zai-Qun; European Journal of Medicinal Chemistry; vol. 81; (2014); p. 227 – 236;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenecarboxylic acid, and cas is 1271-42-7, its synthesis route is as follows.,1271-42-7

Briefly, to a solution of Fc-COOH (5.65 mmol, 1.3 g) in dry DCM at 0 C, Et3N (6.19 mmol, 0.87 mL), HOBt (6.19 mmol, 0.84 g) and HBTU (6.19 mmol, 2.4 g) were added, reacted 1 h at 0 C, then 1 g H-Gly-OMe by treatment with Et3N in DCM (5 mL) was added.

With the complex challenges of chemical substances, we look forward to future research findings about 1271-42-7,belong iron-catalyst compound

Reference£º
Article; Zhou, Binbin; Li, Chun-Lan; Hao, Yuan-Qiang; Johnny, Muya Chabu; Liu, You-Nian; Li, Juan; Bioorganic and Medicinal Chemistry; vol. 21; 2; (2013); p. 395 – 402;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenecarboxylic acid, and cas is 1271-42-7, its synthesis route is as follows.,1271-42-7

Oxalyl chloride (2 mL) was added to ferrocene carboxylic acid (230 mg, 1 mmol) cooled by ice bath. 5 min after, the cooled bath was removed and the solution was stirred at room temperature for 3 h. Excess of oxalyl chloride was removed under vaccuo. Dichloromethane (4 mL) was added. The mixture obtained was added into a solution of E-4 (130 mg, 0.3 mmol) and pyridine (79 mg, 1 mmol) in dichloromethane (4 mL). The mixture was stirred for 1.5 h and poured in water (40 mL). The compound was extracted with 2 ¡Á 40 mL of dichloromethane and washed with 40 mL of water. The solution was dried over magnesium sulphate, filtered and evaporated. The crude product obtained was purified by flash chromatography with silica gel column using CH2Cl2:petroleum ether 3:1 as an eluent. E-5 was obtained as an orange solid (90 mg, 51% yield).Mp = 148 C (diethyl ether/hexane). Rf: 0.66 (diethyl ether:pentane 1:1). 1H NMR (300 MHz, CDCl3): delta 0.16 and 0.22 (s, s, 6H, 6H, 2 (CH3)2Si); 0.93 (t, 3H, J = 7.4 Hz, CH3); 0.95 and 1.00 (s, s, 6H, 6H, 2 (CH3)3Si); 2.46 (q, 2H, J = 7.4 Hz, CH2); 4.23 (s, 5H, Cp), 4.39 and 4.73 (broad s, broad s, 2H, 2H, C5H4); 6.66 and 6.83 (d, d, 2H, 2H, J = 8.5 Hz, C6H4); 6.81 and 6.97 (d, d, 2H, 2 H, J = 8.5 Hz, C6H4); 7.08 and 7.23 (d, d, 2H, 2H, J = 8.5 Hz, C6H4N). 13C NMR (75.47 MHz, CDCl3): delta -4.4 (CH3Si); 13.6 (CH3); 18.2 and 18.3 (t-BuC); 25.7 (t-Bu); 29.0 (CH2); 68.5 (2 CH, C5H4); 70.2 (Cp); 71.2 (2 CH, C5H4); 118.6, 119.6, 119.7, 130.6, 130.7, 131.6 (6CH, 3 C6H4); 135.4, 135.35, 136.7, 137.3, 139.4, 141.3, 153.8, 154.3 (8 Cq, 3 C6H4 + C=C), 168.2 (CO). IR (CH2Cl2, cm-1): 1671 (CO). MS (EI): 771.24 [M]+, 714.26 [M-tBu]+. Analyse: C45H57FeNO3Si2¡¤H2O cald.: C, 68.42; H, 7.53; N, 1.77. Found: C, 68.15; H, 7.53; N, 1.68.

1271-42-7 is used more and more widely, we look forward to future research findings about Ferrocenecarboxylic acid

Reference£º
Conference Paper; Dallagi, Tesnim; Saidi, Mouldi; Vessieres, Anne; Huche, Michel; Jaouen, Gerard; Top, Siden; Journal of Organometallic Chemistry; vol. 734; (2013); p. 69 – 77;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenecarboxylic acid, and cas is 1271-42-7, its synthesis route is as follows.,1271-42-7

Preparation of Fc-NHS: (0147) Fc-NHS was synthesized following a reported method (C. Feng, G. L. Lu, Y. J. Li, X. Y. Huang, Langmuir 2013, 29, 10922-10931). Fc-COOH (49.9 mg, 0.22 mmol), EDC (58.6 mg, 0.32 mmol), and NHS (37.5 mg, 0.32 mmol) were dissolved in dry DCM (5 mL). The reaction mixture was stirred for 24 h at room temperature. After filtering, the filtrate was concentrated and dried in vacuo. Fc-NHS was obtained by silica gel column chromatography (dichloromethane:methanol=10:1) as an orange solid. (0148) 1H-NMR (400 MHz, CDCl3, 298 K): delta=2.93 (s, 4H, -CH2-CH2-), 4.42 (s, 5H, Cp), 4.60 (m, 2H, Cp), 4.97 (m, 2H, Cp). (0149) Preparation of Fc-CONH-(CH2)2-NH2:

With the complex challenges of chemical substances, we look forward to future research findings about 1271-42-7,belong iron-catalyst compound

Reference£º
Patent; Xiong, May Pang; Liu, Zhi; Wang, Yan; (39 pag.)US2016/184344; (2016); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Name is Ferrocenemethanol, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1273-86-5, its synthesis route is as follows.,1273-86-5

General procedure: To a mixture of 1.0 mmol of ferrocenylcarbinol and 1.0 mmol of the corresponding heterocycle in 1.0 ml of methylene dichloride, 0.18 ml of 45 % aqueous solution of fluoroboric acid was added under vigorous stirring. The agitation was continued for 5 min then Et2O (15 ml), the same amount of cold water, and 5-10 mg of ascorbic acid were added to the reaction flask. After vigorous shaking of the mixture the organic solution was separated, washed with cold water (3¡Á15 ml), the solvent was removed and the residue was dried over CaCl2. All types of products (pyrrolidine as well as imidazolidine and thiazolidine derivatives) were equally purified, namely by column chromatography (silica, eluent hexane EtOAc 3:1), and solids obtained after chromatography were crystalized from ethanol.1-(1-Ferrocenylmethyl)pyrrolidine-2-thione (5). (85%); orange powder; mp 104.8 – 105.6o. 1H NMR (400 MHz, CDCl3) delta (ppm): 2.02 (m, 2, 2), 2.61 (m, 2, 2), 3.90 (m, 2, 2), 4.12 (s, 2H, Fc), 4.14 (s, 2, 2), 4.13 (s, 5H, Fc), 4.25 (s, 2H, Fc). 13C NMR (100 MHz, CDCl3) delta (ppm): 19.8 (CH2), 45.2 (CH2), 49.3 (CH2), 52.1 (CH), 66.0 (C5H4), 67.6 (C5H4), 68.8 (C5H4), 68.9 (C5H4), 69.1 (C5H5), 86.9 (ipso-C5H4), 200.1 (C=S) Calc. for C15H17FeNS: 61.22; H, 5.74; N, 4.69; Fe, 18.67; S, 10.72. Found: C, 60.21; H, 5.73; Fe, 18.66; N, 4.68; S, 10.72. EI/MS, m/z (RI%): 299 [M]+ (46).

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenemethanol

Reference£º
Article; Rogatkina, Elena Yu.; Ivanova, Anna S.; Rodionov, Alexey N.; Peregudov, Alexander S.; Korlyukov, Alexander A.; Volodin, Alexander D.; Belousov, Yury A.; Simenel, Alexander A.; Arkivoc; vol. 2018; 5; (2018); p. 272 – 282;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-42-7, Ferrocenecarboxylic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Oxalyl chloride (0.058 mL, 0.66 mmol) was added dropwise over 1 min to a solution of ferrocene monocarboxylic acid (0.0777 g, 0.338 mmol) in dichloromethane (3.0 mL) and N,N-dimethylformamide (1-3 drops). The mixture stirred for 30 min and concentrated with a stream of nitrogen gas, and then subjected to vacuum for 10 min. The resultant crude oil was used without further purification.

1271-42-7, 1271-42-7 Ferrocenecarboxylic acid 499634, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Jones, Ian M.; Knipe, Peter C.; Michaelos, Thoe; Thompson, Sam; Hamilton, Andrew D.; Molecules; vol. 19; 8; (2014); p. 11316 – 11332;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion