Day: November 2, 2020

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 1.0 mmol of ferrocenylcarbinol and 1.0 mmol of the corresponding heterocycle in 1.0 ml of methylene dichloride, 0.18 ml of 45% aqueous solution of fluoroboric acid was added under vigorous stirring. The agitation was continued for 5 min then Et2O (15 ml), the same amount of cold water, and 5-10 mg of ascorbic acid were added to the reaction flask. After vigorous shaking of the mixture the organic solution was separated, washed with cold water (5 15 ml), the solvent was removed and the residue was dried over CaCl2. 3-Ferrocenylmethylbenzo[d]thiazole-2(3H)-thione (5a) Yield 47%. Dark brown crystals, m.p. 134-135 C. Anal.: ? 59.27; ? 4.09; N 3.80; S 17.50%. Calc. for ?18?15FeNS2: ? 59.18; ? 4.14; N 3.83; S 17.56%. EI/MS, m/z (RI%): 365 [M]+ (78). 1? NMR (CDCl3, delta, ppm): 4.12 (s, 2H, Fc), 4.24 (s, 5H, Fc), 4.51 (s, 2H, Fc), 5.44 (s, 2H, CH2), 7.32-7.42 (m, 4H, Het). 13C NMR (CDCl3, delta, ppm): 45.5 (CH2), 68.4 (C5H4), 69.0 (C5H5), 69.9 (C5H4), 81.2 (ipso-C5H4), 112.8 (C-4, Het), 121.3 (C-7, Het), 124.7 (C-6, Het), 126.8 (C-5, Het), 127.6 (C-8, Het), 141.3 (C-9, Het), 189.1 (C=S).

1273-86-5, As the paragraph descriping shows that 1273-86-5 is playing an increasingly important role.

Reference£º
Article; Rodionov, Alexey N.; Zherebker, Kira Ya.; Snegur, Lubov V.; Korlyukov, Alexander A.; Arhipov, Dmitry E.; Peregudov, Alexander S.; Ilyin, Mikhail M.; Nikitin, Oleg M.; Morozova, Nataliya B.; Simenel, Alexander A.; Journal of Organometallic Chemistry; vol. 783; (2015); p. 83 – 91;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

General procedure: To a solution of ferrocenylcarbinol, FcCHR(OH), (1.0 mmol) and 2-thiobenzimidazole (1.0 mmol) in acetone (5.0 ml) two drops of trifluoroacetic acid were added. The reaction mixture was stirred overnight until the residue was formed. Then the residue was filtered, washed with cold ether (2 x 20 ml) and dried in vacuo over CaCl2. N-ferrocenylmethyl-2-thio-benzoimidazole (3a) Yield 74%. Yellow powder, m.p. 198-200?. Anal.: ? 60.81; ? 4.77; N 7.81; S 8.76%. Calc. for ?18?16FeN2S: ? 60.52; ? 4.80; N 7.84; S 8.98%. EI-MS, m/z (RI, %): 348 [M]+ (83). 1? NMR (CDCl3, delta, ppm): 4.11 (s, 2H, Fc); 4.25 (s, 5H, Fc); 4.49 (s, 2H, Fc); 5.28 (s, 2H, CH2); 7.15-7.22 (m, 4H, Het); 10.43 (s, 1H, SH). 13C NMR (CDCl3, delta, ppm): 51.7 (CH2), 66.3 (C5H4), 66.9 (C5H4), 69.3 (C5H4), 69.7 (C5H5), 86.9 (ipso-C5H4), 109.9 (Het, C-5), 111.7 (Het, C-6), 122.8 (Het, C-4), 123.2 (Het, C-7), 128.9 (Het, C-9), 131.0 (Het, C-8), 166.7 (C-S).

1273-86-5, 1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Rodionov, Alexey N.; Zherebker, Kira Ya.; Snegur, Lubov V.; Korlyukov, Alexander A.; Arhipov, Dmitry E.; Peregudov, Alexander S.; Ilyin, Mikhail M.; Nikitin, Oleg M.; Morozova, Nataliya B.; Simenel, Alexander A.; Journal of Organometallic Chemistry; vol. 783; (2015); p. 83 – 91;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Name is Vinylferrocene, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1271-51-8, its synthesis route is as follows.,1271-51-8

General procedure: Synthesized according to general procedure C using hydrazone (0.0800 g, 0.255 mmol), vinyl-ferrocene (0.0541 g, 0.255 mmol) in trifiuorotoluene (1.28 mL) and heated at 80 C for three hours. Volatiles were removed and the crude product was isolated by column chromatography with 100% CH2CI2, then 50% EtOAc/w-hexanes and gradually increased to 100% EtOAc. The title compound was obtained as dark red crystals (0.1024 g, 0.237 mmol, 93 % isolated yield). TLC Rf = 0.22 in 100 % EtOAc. ? NMR (CDC13, 300 MHz) delta ppm 8.90 (d, J = 7.6, 1H), 7.97 (dd, J = 7.1, 4.0, 2H), 7.62-7.48 (m, 4H), 7.30 (t, J = 7.5, 1H), 6.35-6.33 (m, 1H), 4.36 (d, J = 20.6, 2H), 4.15 (d, J = 0.3, 1H), 3.84 (s, 1H), 3.34-3.33 (m, 12H), 3.14 (d, J = 15.7, 1H); 13C NMR (CDC13, 100 MHz) delta ppm 184.3, 140.7, 139.9, 138.3, 132.2 (CH), 131.1 (CH), 130.3 (CH), 129.8 (C), 129.3 (CH), 128.6 (CH), 127.0 (CH), 121.5 (CH), 120.9 (CH), 89.2 (C), 69.5 (CH), 69.3 (CH), 67.8 (CH), 67.5 (CH), 67.4 (CH), 66.6 (CH), 40.4 (CH2); IR (film); 3086, 2975, 1664, 1546, 1273, 1120, 733 cm”1; HRMS (EI): Exact mass calcd for C28H26FeiN20i[M]+: 432.0925; found: 432.0951.

With the complex challenges of chemical substances, we look forward to future research findings about Vinylferrocene

Reference£º
Patent; UNIVERSITY OF OTTAWA; BEAUCHEMIN, Andre Martin; CLAVETTE, Christian; GAN, Wei; MARKIEWICZ, Thomas; TODERIAN, Amy Beverly; WO2013/67646; (2013); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-42-7,Ferrocenecarboxylic acid,as a common compound, the synthetic route is as follows.

Ferrocenecarbonyl chloride was prepared in a schlenk line system to ensure moisture free environment as reported before [21]. In a typical reaction, ferrocene carboxylic acid (10.3601 g, 45.0 mmol) was firstly dried under vacuum at 50 C for 30 min and then dissolved in 75.0 mL of freshly distilled DCM. After that, pyridine(7.20 mL, 90.36 mmol) was added to the previous solution followed by the dropwise addition of oxalyl chloride (7.75 mL, 90.36 mmol) at 25 C. The reaction mixture was stirred for 30 min first at 25 C and then refluxed for 5 h. The contents of the reaction flask were evaporated under vacuum and petroleum ether (80.0 mL) was added. The mixture was stirred for 2 h at 90 C at this stage. At last, the solvent was evaporated to get the dried ferrocene monocarbonyl chloride.

1271-42-7, 1271-42-7 Ferrocenecarboxylic acid 499634, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Khan, Amin; Wang, Li; Yu, Haojie; Haroon, Muhammad; Ullah, Raja Summe; Nazir, Ahsan; Elshaarani, Tarig; Usman, Muhammad; Fahad, Shah; Naveed, Kaleem-ur-Rehman; Journal of Organometallic Chemistry; vol. 880; (2019); p. 124 – 133;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-51-8, Vinylferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In an Schlenk tube under argon one of the following central coresC1, or C2 was mixed with 5percent palladium (II) acetate, Pd(OAc)2, 10percentTris(o-tolyl)phosphine, P(o-tol)3, and vinyl ferrocene, 1-Fc, in triethylamine/THF, 15 mL/15 mL. The resulting mixture was stirred and refluxedovernight. After removing the solvent under reduced pressure,the oil obtained was washed with distillated water and extracted inCH2Cl2 three times and dried over MgSO4. The extract was concentratedto dryness and purified by column chromatography (silica gel60) using hexane/CH2Cl2 2:1 (V/V) mixtures as eluent. The correspondingcompounds were isolated after removing the solvent in a rotaryevaporator., 1271-51-8

The synthetic route of 1271-51-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Santos, Juan C.; Madrid-Moline, Franco; Cisternas, Carlos A.; Paul, Frederic; Escobar, Carlos A.; Jara-Ulloa, Paola; Trujillo, Alexander; Inorganica Chimica Acta; vol. 486; (2019); p. 95 – 100;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Name is Ferrocenylacetic acid, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1287-16-7, its synthesis route is as follows.,1287-16-7

General procedure: A mixture of ferrocene acetic acid (1 mmol), the required 3-substituted-4-amino-5-mercapto-1,2,4-triazole(1 mmol), and p-toluenesulfonic acid (0.1 mmol) in DMF(10 mL) was stirred until a homogeneous solution was obtained. The mixture was exposed to microwave irradiation for about 3 min at 350 W and then cooled and poured into crushed ice. The mixture was adjusted to pH 7 with potassium carbonate and potassium hydroxide and then kept overnight at room temperature. The crude product was filtered off, dried and recrystallized from 80% ethanol to afford the pure product (Scheme 1). 6-Ferrocene methylene-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (1a) Brown solid; Yield: 82%; m.p.: 165-168 C; IR (KBr, nu/cm-1): 3085 (s), 2920 (m), 1604 (s), 656 (m), 487 (m); 1HNMR (CDCl3, 400 M, delta, ppm): 9.98 (s, 1H, N=CH), 4.30(s, 2H, C5H4),4.25 (s, 2H, C5H4),4.16 (s, 5H, C5H5),2.20(s, 2H, CH2);13C NMR (CDCl3, 100 M, delta, ppm): 167.6,161.0, 160.4, 137.2, 130.2, 121.3, 32.1; Anal. Cald. forC14H12N4SFe:C, 51.85; H, 3.70; N, 17.28; Found C, 51.68;H, 3.59; N, 17.51%.

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

Reference£º
Article; Liu, Yuting; Xin, Hong; Yin, Jingyi; Yin, Dawei; Transition Metal Chemistry; vol. 43; 5; (2018); p. 381 – 385;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14024-18-1,Iron(III) acetylacetonate,as a common compound, the synthetic route is as follows.

To prepare nanosized iron(III) oxide, 0.5 g ofFe(acac)3 was dissolved in 10 mL of DPE or a mixture of DPE with the appropriate amount of surfactant.Next, 40 mL of DPE or a DPE-surfactant mixture was heated to required temperature on an oil bath withvigorous magnetic stirring in a two-necked round-bottomed flask equipped with a reflux condenser. Next, a solution of Fe(acac)3 was quickly added via a syringe into the hot DPE or DPE-surfactant solution. The resultant mixture was kept for 2 h with vigorous stirring for complete thermolysis and formation of nanosized particles. Then, the mixture was cooled and analyzed.

14024-18-1, As the paragraph descriping shows that 14024-18-1 is playing an increasingly important role.

Reference£º
Article; Lyadov; Kochubeev; Koleva; Parenago; Khadzhiev; Russian Journal of Inorganic Chemistry; vol. 61; 11; (2016); p. 1387 – 1391; Zh. Neorg. Khim.; vol. 61; 11; (2016); p. 1440 – 1444,5;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Name is Vinylferrocene, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1271-51-8, its synthesis route is as follows.,1271-51-8

Add 1t (0.2 mmol, 42mg) of vinyl ferrocene, 2a (0.2 mmol, 29 muL), toluene (1 mL), and Cp to the reaction tube in this order.2ZrH2(0.01 mmol, 2.3 mg). Stir the reaction at room temperature under a nitrogen (1 atm) atmosphere.GC detection until the reaction is complete.Filter through celite, spin dry the solvent under reduced pressure, and purify the residue by silica gel column chromatography. Use petroleum ether: ethyl acetate (40 mL: 1 mL) as the eluent to obtain ferrocene vinyl boric acid as a yellow oil Pinacol ester 3t (63mg, 80%).

With the complex challenges of chemical substances, we look forward to future research findings about Vinylferrocene

Reference£º
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute; Wu Lipeng; Shi Xiaonan; (17 pag.)CN110483561; (2019); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO306,mainly used in chemical industry, its synthesis route is as follows.,1273-86-5

Cyanuric chloride (TCT)(0.184g, 1mmol) was added intoa 50mL one-necked round-bottom flask with 10mL dry THF.The mixture was stirred in a cold bath and ferrocenemethanol(0.864g, 4mmol) in 10mL dry THF was slowly added tothe reaction system using a syringe. The mixture was stirred in the cold bath for 30min. Subsequently, DMAP (0.366g,3mmol) in 10mL dry THF was also slowly added to the reactionsystem using a syringe. The mixture was stirred in thecold bath for an additional 30min. Then, the temperature naturally rose to room temperature and was stirred for 8h.This time, the reaction system was refluxed. After the completion of the reaction indicated by simple TLC analysis, the solvent was evaporated under the reduced pressure, and theresidual was directly purified by column chromatography(EtOAc/Petroleum ether: 5:12:1) to obtain the target compound 1. 0.506g, light yellow solid, yield, 70%, Mp.:199-201 oC, 1H NMR(400MHz, CDCl3) (ppm): 4.73(s, 6H,32H of C5H4), 4.38(s, 6H, 32H of C5H4), 4.15(s, 15H,3C5H5), 4.10(s, 6H, 3CH2); 13C NMR(100MHz, CDCl3) (ppm): 148.7(3C=N), 81.5(6C), 70.4(6C), 68.7(15C),68.5(3C), 42.1(3CH2); ESI-MS(m/e, 100%) 746([M+23]+,100); Anal.calcd. for C36H33N3O3Fe3: N, 5.81; C, 59.75; H,4.56; Found: N, 5.75; C, 59.57 ; H, 4.64

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenemethanol,belong iron-catalyst compound

Reference£º
Article; Yong, Jianping; Wu, Xiaoyuan; Liao, Jianzhen; Lu, Canzhong; Liu, Xiaolong; Medicinal Chemistry; vol. 12; 5; (2016); p. 426 – 431;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-51-8, Vinylferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4H-pyrane derivative (4, 7a and7b) (1 mmol), 4-(2-ferrocenylvinyl)benzaldehyde (2 mmol) andpiperidine (1 mL) in dry acetonitrile (10 mL) was refluxed for 1 hunder argon atmosphere. The reaction was controlled with TLCmethod by monitoring the 4-(2-ferrocenylvinyl) benzaldehyde inthe solution of reaction. After the completion of the reaction, thesolution was cooled to room temperature and the product waspurified using column chromatography over silica gel and hexane/EtOAC as eluent. Further purification was performed by recrystallizationfrom hexane and EtOAc to give corresponding compoundas a pure solid. Specific details for each compound are given belowand spectral data in each case is similar to reported one in above.2,6-Bis [4-(2-ferrocenylvinyl)styryl]-4H-pyran-4-one (6):from 0.1 g (0.32 mmol) 4-(2-Ferrocenylvinyl) benzaldehyde and0.02 g (0.11 mmol) 2, 6-Methyl-4H-pyran-4-one, 0.08 g (0.13 mmol)orange solid was obtained in 75percent yield.

1271-51-8, The synthetic route of 1271-51-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Teimuri-Mofrad, Reza; Rahimpour, Keshvar; Ghadari, Rahim; Journal of Organometallic Chemistry; vol. 846; (2017); p. 397 – 406;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion