Analyzing the synthesis route of 1273-86-5

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenemethanol,belong iron-catalyst compound

As a common heterocyclic compound, it belong iron-catalyst compound,Ferrocenemethanol,1273-86-5,Molecular formula: C11H3FeO,mainly used in chemical industry, its synthesis route is as follows.,1273-86-5

General procedure: ferrocenemethanol was added to the substrates 1a-l in a round bottom flask and the mixture was heated under stirring at 50-90C (as reported in Table 1), the reaction was monitored by TLC and capillary electrophoresis, after completion of reaction. The reaction mixture was flash chromatographed by silica gel column to give the pure compounds 3a-l as reported in Table 1. Typical eluent: hexane/ethyl acetate= 7/3.

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenemethanol,belong iron-catalyst compound

Reference£º
Article; Shisodia, Suresh Udhavrao; Auricchio, Sergio; Citterio, Attilio; Grassi, Marco; Sebastiano, Roberto; Tetrahedron Letters; vol. 55; 4; (2015); p. 869 – 872;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Analyzing the synthesis route of 1271-51-8

With the synthetic route has been constantly updated, we look forward to future research findings about Vinylferrocene,belong iron-catalyst compound

As a common heterocyclic compound, it belong iron-catalyst compound,Vinylferrocene,1271-51-8,Molecular formula: C12H3Fe,mainly used in chemical industry, its synthesis route is as follows.,1271-51-8

In anhydrous THF (1 mL) was dissolved 6 molpercent Cu(OAc) 2 (10.9 mg,0.066 mmol) and 6.6 molpercent of ligand (R)-DTBM-SEGPHOS (78 mg,0.060 mmol). The mixture was stirred for 15 min at r.t., then DMMS(0.5 mL, 4 equiv, 4 mmol) was added dropwise and stirring was con-tinued for 10 min at the same temperature. The solution of amine 7(381 mg, 1.2 mmol) and vinylferrocene 4 (212 mg, 1 mmol) was thenadded by using Schlenk techniques to the tube containing the solu-tion of [L*CuH] complex. The reaction mixture was stirred at 40 ¡ãCovernight, then the mixture was diluted with EtOAc (5 mL) and 5percentsolution of Na 2 CO 3 (5 mL) was added dropwise. The solution was ex-tracted with EtOAc (3 ¡Á 25 mL), the collected organic layers werewashed with brine (25 mL), dried over Na 2 SO 4 , filtrated, and the sol-vent was removed under reduced pressure to afford the crude prod-uct. The crude product was purified by chromatography on SiO 2 (hex-anes/EtOAc, 30:1 + 1percent Et 3 N; R f = 0.4) to afford target product 8.Yield: 68 mg (18percent); orange solid; mp 62?65 ¡ãC; [alpha] D20 ?14.5 (c 1.00,CHCl 3 ); HPLC analysis (Chiralcel OD-H; hexane/ i PrOH, 99:1; 0.8mL/min; 254 nm) indicated 20percent ee: t R = 5.9 (major), 6.5 (minor) min.IR (ATR): 1234, 1103, 1068, 1022, 998, 822, 749, 728, 697, 514, 487cm ?1 .1 H NMR (600 MHz, CDCl 3 ): delta = 7.39 (d, J = 7.4 Hz, 4 H, -Ph), 7.31 (t, J =7.6 Hz, 4 H, -Ph), 7.23 (t, J = 7.3 Hz, 2 H, -Ph), 4.27?4.27 (m, 1 H, Fc),4.18?4.14 (m, 3 H, Fc), 4.02 (s, 5 H, Cp Fc ), 3.81 (q, J = 6.9 Hz, 1 H, H alpha ),3.53 (d, J = 14.1 Hz, 2 H, CH 2 -Ph), 3.36 (d, J = 14.1 Hz, 2 H, -CH 2 -Ph),1.47 (d, J = 6.9 Hz, 3 H, -CH 3 ).13 C NMR (151 MHz, CDCl 3 ): delta = 140.9 (2¡ÁC, Cq Ph ), 128.6 (4¡ÁC, -Ph),128.2 (4¡ÁC, -Ph), 126.7 (2¡ÁC, -Ph), 88.9 (Cq Fc ), 69.1 (-CH Fc ), 68.7 (5¡ÁC,Cp Fc ), 67.6 (-CH Fc ), 67.1 (-CH Fc ), 66.9 (-CH Fc ), 52.3 (2¡ÁC, -CH 2 -Ph), 52.2(-CH alpha ), 15.4 (-CH 3 ).HRMS (ESI): m/z calcd for [M + H + ] C 26 H 28 FeN + : 410.1571; found:410.1565.

With the synthetic route has been constantly updated, we look forward to future research findings about Vinylferrocene,belong iron-catalyst compound

Reference£º
Article; Plevova, Kristina; Mudrakova, Brigita; ?ebesta, Radovan; Synthesis; vol. 50; 4; (2018); p. 760 – 763;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Some tips on 1271-55-2

1271-55-2 Acetylferrocene 79159, airon-catalyst compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-55-2,Acetylferrocene,as a common compound, the synthetic route is as follows.

General procedure: A solution of pure TsNHNH2 (15 mmol) in methanol (30 mL) was stirred and heated to 60 C until the TsNHNH2 dissolved. The mixture was cooled to room temperature. Then a solution of ferrocenylketone (10 mmol) in methanol was dropped into the mixture slowly. After approximately 0.5-2 h, the crude products could be obtained as solid precipitate. The precipitate was washed with petroleum ether then removed in vacuo to give the pure products. In general, the yields were 68-86 %. Because of the relatively low activity of some ketones, their reactions at room temperature may be incomplete. They should be reacted in refluxing methanol. The reaction could be monitored by TLC., 1271-55-2

1271-55-2 Acetylferrocene 79159, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Ling, Li; Hu, Jianfeng; Huo, Yanhong; Zhang, Hao; Tetrahedron; vol. 73; 1; (2017); p. 86 – 97;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

The important role of 1273-86-5

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenemethanol

Name is Ferrocenemethanol, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1273-86-5, its synthesis route is as follows.,1273-86-5

General procedure: To a solution of ferrocenyl alcohol 1 or 2 (2.0 mmol) and 3-amino-o-carborane hydrochloride (2.0 mmol) in dry MeNO2 (5mL) CAN (87 mg, 0.16 mmol, 0.8 mol%) was added. The resultingmixture was stirred at room temperature until TLC analysisrevealed complete disappearance of starting alcohol 1 or 2 (usually3-4 h). Then EtOAc (10 mL) was added to a reaction mixture andresulting solution was washed repeatedly with water, dried withanhydrous Na2SO4, filtered and the solvents were evaporated invacuo. The remained product was treated with CH2Cl2 (50 ml),passed through a silica gel layer (2.0 cm) on the filter to give correspondingproducts 15, 17 after the evaporation of volatiles atreduced pressure.

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenemethanol

Reference£º
Article; Ol’shevskaya, Valentina A.; Makarenkov, Anton V.; Borisov, Yury A.; Ananyev, Ivan V.; Kononova, Elena G.; Kalinin, Valery N.; Ponomaryov, Andrey B.; Polyhedron; vol. 141; (2018); p. 181 – 190;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Some tips on Ferrocenemethanol

With the complex challenges of chemical substances, we look forward to future research findings about 1273-86-5,belong iron-catalyst compound

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenemethanol, and cas is 1273-86-5, its synthesis route is as follows.,1273-86-5

General procedure: A mixture of aryl alcohol (1 mmol) and [FemDMMerA]Y (100 mg) in solvent(5 mL) was refluxed in oil bath. After completion of the reaction as monitored byTLC, the reaction mixture was filtered to remove insoluble SILP catalyst.Evaporation of solvent in vacuuo followed by column chromatography over silicagel using petroleum ether/ethyl acetate (95:5 v/v) afforded pure aldehydes.

With the complex challenges of chemical substances, we look forward to future research findings about 1273-86-5,belong iron-catalyst compound

Reference£º
Article; Kurane, Rajanikant; Bansode, Prakash; Khanapure, Sharanabasappa; Salunkhe, Rajashri; Rashinkar, Gajanan; Research on Chemical Intermediates; vol. 42; 12; (2016); p. 7807 – 7821;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

New learning discoveries about 1271-55-2

With the rapid development of chemical substances, we look forward to future research findings about Acetylferrocene

Acetylferrocene, cas is 1271-55-2, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-55-2

General procedure: To a solution of acetyl ferrocene (228 mg, 1mmol) in ethyl alcohol (15 ml) was added KOH (110 mg, 2 mmol) and stirred at room temperature for 15 min, then appropriate aromatic aldehyde (1 mmol) in ethyl alcohol (5 ml) was slowly added and the mixture was allowed to stirred at room temperature. After complete consumption of acetyl ferrocene (monitored by TLC, a red to purple colour solid was formed), 2-hydrazinobenzothiazole (165 mg, 1.0 mmol), KOH (110 mg, 2 mmol) and additional ethyl alcohol (5 ml) and was slowly added and the resulting mixture was refluxed for overnight. After completion of the reaction (monitored by TLC, an orange to red colour solid was formed), the reaction mixture was cooled, the solid formed was filtered, washed with cold ethanol-water mixture, water and air dried. The resulting solid was purified by column chromatography using n-hexane/ethyl acetate mixture (9:1 to 8:2) to obtain the ferrocene derivative.

With the rapid development of chemical substances, we look forward to future research findings about Acetylferrocene

Reference£º
Article; Kiran Kumar, Chakka; Trivedi, Rajiv; Giribabu, Lingamallu; Niveditha, Surukonti; Bhanuprakash, Kotamarthi; Sridhar, Balasubramanian; Journal of Organometallic Chemistry; vol. 780; (2015); p. 20 – 29;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Some tips on 1273-86-5

1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

General procedure: ferrocenemethanol was added to the substrates 1a-l in a round bottom flask and the mixture was heated under stirring at 50-90C (as reported in Table 1), the reaction was monitored by TLC and capillary electrophoresis, after completion of reaction. The reaction mixture was flash chromatographed by silica gel column to give the pure compounds 3a-l as reported in Table 1. Typical eluent: hexane/ethyl acetate= 7/3., 1273-86-5

1273-86-5 Ferrocenemethanol 10856885, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Shisodia, Suresh Udhavrao; Auricchio, Sergio; Citterio, Attilio; Grassi, Marco; Sebastiano, Roberto; Tetrahedron Letters; vol. 55; 4; (2015); p. 869 – 872;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Downstream synthetic route of Ferrocenemethanol

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenemethanol,belong iron-catalyst compound

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO308,mainly used in chemical industry, its synthesis route is as follows.,1273-86-5

Under a nitrogen atmosphere, 4-aminobenzenesulfonamide (172 mg, 1 mmol)[Cp * IrCl2] 2 (8 mg, 0.01 mmol, 1 mol%),Cesium carbonate (65 mg, 0.2 mmol),Ferrocene methanol (259 mg, 1.2 mmol)Tert-amyl alcohol (1.0 mL) was added sequentially to a 25 mL Schlenk reaction flask.The mixture was allowed to react at 120 C for 12 hours,Cooled to room temperature,The solvent was removed under vacuum.And then passed through a column chromatography (developing solvent: ethyl acetate / n-hexane)To pure target compound, yield: 80%.

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenemethanol,belong iron-catalyst compound

Reference£º
Patent; NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY; LI, FENG; LU, LEI; MA, JUAN; (16 pag.)CN106146358; (2016); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Downstream synthetic route of 1271-42-7

1271-42-7, As the paragraph descriping shows that 1271-42-7 is playing an increasingly important role.

1271-42-7, Ferrocenecarboxylic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

At room temperature and in an atmosphere of nitrogen, oxalyl chloride (2 mmol, 0.17 ml) is dripped into a suspension of ferrocencarboxylic acid (0.25 g, 1 mmole) in anhydrous CH2C12 (5 ml) . A dark red coloured solution is obtained that is left under stirring for 3 0 minutes. The excess (COCl)2 is eliminated by distillation under vacuum and the dark oil residue, dissolved in anhydrous CH2C12 (5 ml) , is dripped at room temperature into a solution of 1,3-diamino-2-propanol (0.45 mmol, 40 mg) and Et3N (2 mmol, 0.3 ml) in CH2C12 (2 ml) . The solution is stirred for 2h and precipitation of an orange coloured solid is obtained. The solvent is evaporated and the residue is taken with 10 ml of a CH2C12/Et20 3:7 mixture and it is filtered, washing with 3 0 ml of the same mixture.195 mg of orange solid is obtained with a yield of 94%. M.p. 176-177C (pentane) . XH NMR (DMSO, 8): 3.27 (m, 4H, CH2NHC0FC, OH); 3.74 (m, 1H, CHOH) ; 4.17 (m, 10H, CH Fc) ; 4.82 (t, 4H, CH Fc) ; 4.34 (t, 4H, CH Fc) ; 7.9 (t, 2H, NH) ; 13C NMR (DMSO, 5): 43.08; 68.2; 69.2; 69.65; 69.9; 77.5 ; 170. M/z (ESI): 537 (M+Na+) ; 515 (M+l); IR (Nujol, V cm”1) 3294 (NH,OH); 1635 (CO).

1271-42-7, As the paragraph descriping shows that 1271-42-7 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITA’ DEGLI STUDI DI MILANO; WO2006/6196; (2006); A2;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Some tips on Ferrocenecarboxylic acid

With the complex challenges of chemical substances, we look forward to future research findings about 1271-42-7,belong iron-catalyst compound

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenecarboxylic acid, and cas is 1271-42-7, its synthesis route is as follows.,1271-42-7

A solution of ferrocenecarboxylic acid (232.1 mg, 1 mmol), DIPEA (680 muL, 4 mmol), TBTU (321.1 mg, 1 mmol) and HOBt (135.1 mg, 1 mmol) in dichloromethane (20 ml) was stirred at room temperature for 1 hour. N-Boc-ethylenediamine (158 muL, 1 mmol) was added and the stirring continued for 2 days. The reaction mixture was washed with NaHCO3, brine and citric acid, the organic layer dried over anhydrous sodium sulfate, filtered and evaporated in a vacuum. The crude product was purified by automated flash chromatography (20 % to 80 % ethyl-acetate in n-hexane), Rf = 0.13, EtOAc : hexane = 1 : 1. Yield: 276.7 mg (0.74 mmol, 74 %) of orange powder, Mr (C18H24FeN2O3) = 372.24. ESI-MS (m/z): 395.0 (M+Na+, 66%), 767.1 (2M+Na+, 67%). 1H NMR (300 MHz, CDCl3) delta/ppm: 6.56 (s, 1H), 5.03 (s, 1H), 4.76-4.62 (m, 2H), 4.41-4.28 (m, 2H), 4.21 (s, 5H), 3.56 – 3.43 (m, 2H), 3.37 (t, J = 5.6 Hz, 2H), 1.46 (s, 9H) 13C NMR (150 MHz, CDCl3) delta/ppm: 171.20, 157.40, 79.95, 76.09, 70.55, 69.90, 68.30, 41.22, 40.82, 28.57. IR (KBr) max/cm-1: 3374, 3245, 3002, 2976, 2928, 2880, 1687, 1640, 1536, 1453, 1364, 1267, 1170, 1018, 819, 718, 504, 486. IR (CHCl3, 40 mmol/L) max/cm-1: 3449, 3364, 3008, 2982, 2930, 1700, 1643, 1517, 1368, 1285, 1250, 1167, 998, 826, 483. UV-Vis (CHCl3) lambdamax (epsilon): 443 (219), 350 (431), 306 (1000).

With the complex challenges of chemical substances, we look forward to future research findings about 1271-42-7,belong iron-catalyst compound

Reference£º
Article; Juraj, Natalija P.; Le Pennec, Jeremy; Peri?, Berislav; Kirin, Sre?ko I.; Croatica Chemica Acta; vol. 90; 4; (2017); p. 613 – 623;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion