102-54-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Ferrocene, cas is 102-54-5,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.
Ferrocenecarboxaldehyde was prepared from ferrocene according to the literature.10 Phosphorus oxychloride (50mL, 536mmol) was added dropwise to the dimethylformamide (39.0g, 536mmol) at 0C and the resulting mixture was stirred for 30min at this temperature under a nitrogen atmosphere. Next ferrocene (50.0g, 268mmol) in dry chloroform (250mL) was added dropwise to the mixture for 30min at 0C. After completion of the addition, the reaction mixture was kept stirring for 28h with heating at 55-60C on an oil bath, taking care that the temperature did not exceed 60C. The reaction mixture was then cooled to room temperature and neutralized carefully with an aqueous saturated Na2CO3 solution and then extracted repeatedly with the dichloromethane. The combined organic layer was dried over anhydrous Na2SO4, filtered and the solvent was evaporated under reduced pressure. The residue was purified through silica gel column chromatography using hexane/ ethyl acetate mixture (95:05) as eluent to give ferrocenecarboxaldehyde 1 in 55% yield (31.7g) as a reddish brown solid. (mp: 122C, lit.10 123C); IR (KBr, cm-1): 3093, 2837, 2760, 1683, 1447; 1H NMR (400MHz, CDCl3): deltaH 9.95 (s, 1H); 4.80-4.60 (m, 4H), 4.27 (s, 5H); 13C NMR (100MHz, CDCl3): deltaC 193.63, 79.49, 73.33, 69.78; HRMS-ESI (m/z): [M+H]+ Found 215.0157 and calculated 215.0159 for C11H11FeO.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Ferrocene, 102-54-5
Reference£º
Article; Achari, Kamsali Murali Mohan; Ramanathan, Chinnasamy Ramaraj; Tetrahedron Asymmetry; vol. 28; 6; (2017); p. 830 – 836;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion