Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Elmuradov, Burkhon and a compound is mentioned, 1271-48-3, 1,1′-Ferrocenedicarboxaldehyde, introducing its new discovery. 1271-48-3
Tricyclic quinazoline alkaloids conjugated to ferrocene: Synthesis, structure, and redox behavior of ferrocenylmethylene-substituted 7H-deoxyvasicinones
The first organometallic derivatives of tricyclic quinazoline derivatives are prepared by condensation of the active C-3 methylene group of 7H-deoxyvasicinones with ferrocenecarbaldehyde. By following this route the conjugated parent alkaloid and derivatives with nitro, amino, as well as some alkanoylamino groups at C-7 were attached at the ferrocene moiety, thereby significantly extending the pi system. In addition, the parent compound was subjected to the reaction by treatment with ferrocene-1,1?-dicarbaldehyde, giving rise to the double condensation product, which is only the second case of a 1,1?-disubstituted ferrocene derivative with two alkaloid substituents. A number of the compounds obtained were subjected to X-ray crystallographic analyses. In all cases, the substituents adopt a coplanar conformation with the ferrocene cyclopentadienyl ligands. The influence of the substituents at C-7 through the extended conjugated pi system on the iron atom is reflected by results of cyclic voltammetric measurements as well as by DFT calculations. 7H-Deoxyvasicinones are condensed with ferrocenecarbaldehyde and with ferrocene-1,1?-dicarbaldehyde to generate extended pi systems with coplanar conformations of the two moieties. The products are investigated by crystal structure analyses, cyclic voltammetry, and DFT calculations.
Tricyclic quinazoline alkaloids conjugated to ferrocene: Synthesis, structure, and redox behavior of ferrocenylmethylene-substituted 7H-deoxyvasicinones
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about 4254-15-3!, 1271-48-3
Reference£º
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion