Related Products of 16009-13-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16009-13-5, Name is Hemin, molecular formula is C34H32ClFeN4O4. In a Article£¬once mentioned of 16009-13-5
Effect of ATRX and G-Quadruplex Formation by the VNTR Sequence on alpha-Globin Gene Expression
ATR-X (alpha-thalassemia/mental retardation X-linked) syndrome is caused by mutations in chromatin remodeler ATRX. ATRX can bind the variable number of tandem repeats (VNTR) sequence in the promoter region of the alpha-globin gene cluster. The VNTR sequence, which contains the potential G-quadruplex-forming sequence CGC(GGGGCGGGG)n, is involved in the downregulation of alpha-globin expression. We investigated G-quadruplex and i-motif formation in single-stranded DNA and long double-stranded DNA. The promoter region without the VNTR sequence showed approximately twofold higher luciferase activity than the promoter region harboring the VNTR sequence. G-quadruplex stabilizers hemin and TMPyP4 reduced the luciferase activity, whereas expression of ATRX led to a recovery in reporter activity. Our results demonstrate that stable G-quadruplex formation by the VNTR sequence downregulates the expression of alpha-globin genes and that ATRX might bind to and resolve the G-quadruplex.
Effect of ATRX and G-Quadruplex Formation by the VNTR Sequence on alpha-Globin Gene Expression
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 16009-13-5. In my other articles, you can also check out more blogs about 16009-13-5
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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion