Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis. Safety of 1,1′-Dibromoferrocene, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. In a patent£¬Which mentioned a new discovery about 1293-65-8
Selective borane reduction of phosphinoferrocene carbaldehydes to phosphinoalcohol-borane adducts. the coordination behaviour of 1-(diphenylphosphino)- 1?-(methoxymethyl)ferrocene, a new ferrocene O,P-hybrid donor prepared from such an adduct
The reduction of ferrocene phosphino-aldehydes, R2PfcCHO (R = Ph, 2; Cy, 3; fc = ferrocene-1,1?-diyl, Cy = cyclohexyl) and (S p)-[Fe(eta5-C5H3-1-CHO-2-PPh 2)(eta5-C5H5)] ((S p)-4), with BH3¡¤THF or BH3¡¤ SMe2 in THF at 0 C selectively afforded the corresponding phosphinoalcohol-borane adducts, R2PfcCH2OH¡¤BH 3 (R = Ph, 5; Cy, 6) and (Sp)-[Fe(eta5-C 5H3-1-CH2OH-2-PPh2) (eta5-C5H5)]¡¤BH3 ((S p)-7), in quantitative yields. In contrast, the reactions performed at elevated temperatures favoured the formation of methyl derivatives (e.g., Ph2PfcCH3¡¤BH3 (8)) resulting from overreduction (deoxygenation). The crystal structures of 3, 5, (S p)-7, 8 and Cy2PfcBr (9) have been determined by single-crystal X-ray diffraction analysis. The crystal assemblies of adducts 5 and (Sp)-7 are built up by means of C-H…O contacts, O-H…HB dihydrogen bonds and other soft interactions but, surprisingly, not via the conventional O-H…O hydrogen bonds. Adduct 5 was smoothly deprotected to give the corresponding free phosphine, Ph2PfcCH 2OH (1), and was further used for the preparation of a hybrid phosphinoether ligand, Ph2PfcCH2OMe (11). The latter compound was studied as a donor for Group 8-10 metal ions and for Cu(i), whereupon the following complexes were isolated and structurally characterised: [(eta6-p-cymene)RuCl2(11-kappaP)] (12*), [(eta6-p-cymene)RuCl(11-kappaP)(MeCN)][SbF6] (13*), [RhCl(cod)(11-kappaP)] (cod = eta2: eta2-cycloocta-1,5-diene; 14), trans-[PdCl2(11-kappaP) 2] (trans-15*), [PdCl(mu-Cl)(11-kappaP)]2 (16*), cis- and trans-[PtCl2(11-kappaP)2] (cis-17 and trans-17*), and [Cu(CF3SO3-kappaO)(11- kappaP)(H2O)] (18) (the asterisk indicates that the crystal structure was determined). In all these compounds, ligand 11 behaves as a P-monodentate donor while its ether group remains uncoordinated. This probably reflects structural flexibility of 11 resulting from the presence of the methylene linker and also distinguishes 11 from its known, non-spaced analogue Ph2PfcOMe.
Selective borane reduction of phosphinoferrocene carbaldehydes to phosphinoalcohol-borane adducts. the coordination behaviour of 1-(diphenylphosphino)- 1?-(methoxymethyl)ferrocene, a new ferrocene O,P-hybrid donor prepared from such an adduct
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Reference£º
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion