1287-16-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Ferrocenylacetic acid, cas is 1287-16-7,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.
1) 1.1 mmol of ferrocenyl acetic acid and 1 mmol of 3- (4-nitrophenyl) -4-amino-5-mercapto-1,2,4-triazole were weighed out, Added to a dry 250mL single-necked flask, Then 0.11 mmol p-toluenesulfonic acid was added, To this was added 4 mL of DMF, The glass rod is stirred to dissolve it. 2)The round bottom flask was placed in a microwave reactor, 400W under irradiation once every 30s, Irradiation duration of 4min. After irradiation, cool down. 3) Pour it into a crushed beaker, With potassium carbonate and potassium hydroxide pH = 7, Placed overnight,filter,Washed,dry,The crude product of 3- (4-nitrophenyl) -6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole was obtained,Using a solvent of DMF and absolute ethanol in a volume ratio of 3: 1 mixed solvent,The crude product was recrystallized,That is, a brown solid,The yield was 84%
The chemical industry reduces the impact on the environment during synthesis,1287-16-7,Ferrocenylacetic acid,I believe this compound will play a more active role in future production and life.
Reference：
Patent; Shaanxi University of Science and Technology; Liu, Yuting; Song, Simeng; Yin, Dawei; Jiang, Shanshan; Liu, Beibei; Yang, Aning; Wang, Jinyu; Lyu, Bo; (13 pag.)CN104231004; (2017); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion