Day: June 10, 2021

It is a common heterocyclic compound, the iron-catalyst compound, Aminoferrocene, cas is 1273-82-1 its synthesis route is as follows.

General procedure: Organometallic sulfonamides were prepared following a modification of the procedure described by Alberto and co-workers [41]. An equimolar amount of pyridine was added at room temperature to a solution containing 50mg of P2 or P3 in 7.0mL of anhydrous CH2Cl2. After 15min, the corresponding sulfonyl chloride derivative was added, and the reaction mixture was heated under reflux for 24h. The resulting solution was dried under vacuum. The crude product was purified using silica gel liquid chromatography and a mixture of CH2Cl2/hexane (4:1) as the eluent. All compounds were recrystallized from an acetone/hexane (1:5) mixture by slow evaporation.

1273-82-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,1273-82-1 ,Aminoferrocene, other downstream synthetic routes, hurry up and to see

Reference：
Article; Quintana, Cristobal; Silva, Gisella; Klahn, A. Hugo; Artigas, Vania; Fuentealba, Mauricio; Biot, Christophe; Halloum, Iman; Kremer, Laurent; Novoa, Nestor; Arancibia, Rodrigo; Polyhedron; vol. 134; (2017); p. 166 – 172;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocene, and cas is 102-54-5, its synthesis route is as follows.

General procedure: A solution of acid chloride (63mmol) in 30ml dry dichloromethane was added to a suspension of anhydrous aluminum chloride (8.41g, 63mmol) in 30ml dry dichloromethane and the mixture was stirred at 5C for 1h under Argon. The solution of aluminum chloride: acid chloride complex was added dropwise over 30min to a solution of ferrocene (11.16g, 60mmol) in 100ml dry dichloromethane at 0C. The reaction mixture was warmed to room temperature and stirred for 16h. A solution of NaBH4 (2.38g, 63mmol) in 25ml diglyme was added dropwise to the purple reaction mixture at-5C. An orange solution was formed and stirred at 0C for 1h. The mixture was then hydrolyzed with addition of 20ml water while maintaining its temperature at less than or equal to 10C. The mixture was allowed to separate by settling and the organic phase was then withdrawn. The aqueous phase was extracted with 3 times 30ml of dichloromethane and then all the organic phases are combined. Combined organic layer was washed with 50ml of brine and then dichloromethane was distilled under atmospheric pressure. The diglyme and the residual ferrocene which was found to be entrained by the diglyme were then distilled at reduced pressure approximately 20mm Hg and a column head temperature of 85-95C. The alkylferrocene derivatives were distilled at a more reduced pressure, less than 5mm Hg.

102-54-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,102-54-5 ,Ferrocene, other downstream synthetic routes, hurry up and to see

Reference：
Article; Teimuri-Mofrad, Reza; Safa, Kazem D.; Rahimpour, Keshvar; Journal of Organometallic Chemistry; vol. 758; (2014); p. 36 – 44;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

12093-10-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Ferrocenecarboxaldehyde, cas is 12093-10-6,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a typical procedure, 1.39 mmol of 2?-hydroxyacetophenone (for 1 and 3) or 2?-hydroxy-4?-methoxyacetophenone (for 2 and 4) were dissolved in 40 ml of methanol. To this solution, 4 equivalent of potassium hydroxide were added and stirred for 15 min at room temperature. Then, 1.40 mmol of the appropriate ferrocenecarboxaldehyde derivative, (i.e. 1-ferrocenecarboxaldehyde for 1 and 2 or 1,1-ferrocenedicarboxaldehyde for 3 and 4) were added. The mixture was stirred during three days at room temperature. Then, methanol was evaporated in vacuum (rotary evaporator) and the crude reaction mixture was submitted to column chromatography (silica gel 60, Ethyl acetate: Hexane = 3:10 v/v).

The chemical industry reduces the impact on the environment during synthesis,12093-10-6,Ferrocenecarboxaldehyde,I believe this compound will play a more active role in future production and life.

Reference：
Article; Trujillo, Alexander; Ocayo, Fernanda; Artigas, Vania; Santos, Juan C.; Jara-Ulloa, Paola; Kahlal, Samia; Saillard, Jean-Yves; Fuentealba, Mauricio; Escobar, Carlos A.; Tetrahedron Letters; vol. 58; 5; (2017); p. 437 – 441;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1287-16-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Ferrocenylacetic acid, cas is 1287-16-7,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of ferrocene acetic acid (1 mmol), the required 3-substituted-4-amino-5-mercapto-1,2,4-triazole(1 mmol), and p-toluenesulfonic acid (0.1 mmol) in DMF(10 mL) was stirred until a homogeneous solution was obtained. The mixture was exposed to microwave irradiation for about 3 min at 350 W and then cooled and poured into crushed ice. The mixture was adjusted to pH 7 with potassium carbonate and potassium hydroxide and then kept overnight at room temperature. The crude product was filtered off, dried and recrystallized from 80% ethanol to afford the pure product (Scheme 1).

The chemical industry reduces the impact on the environment during synthesis,1287-16-7,Ferrocenylacetic acid,I believe this compound will play a more active role in future production and life.

Reference：
Article; Liu, Yuting; Xin, Hong; Yin, Jingyi; Yin, Dawei; Transition Metal Chemistry; vol. 43; 5; (2018); p. 381 – 385;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

12126-50-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Bis(pentamethylcyclopentadienyl)iron(II), cas is 12126-50-0,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.

Salt 1 was synthesized as follows. Under a nitrogen atmosphere,SO2Cl2 (0.025 mL, 0.31 mmol) was added dropwise to a dichloromethanesolution (0.5 mL) of [FeCp*2] (48 mg, 0.15 mmol) andstirred for 15 min. The solvent was then evaporated under reducedpressure and vacuum dried. The resulting dark green solid of[FeCp*2]Cl was dissolved in water (0.5 mL), to which an aqueoussolution (0.2 mL) of K [CH2BrBF3] (54 mg, 0.27 mmol) was added and stirred for 15 min. The resulting precipitate was collected by filtration and washed with ether, followed by drying under vacuumto obtain the desired product as a dark green solid. Recrystallizationby slow cooling (-40 C) of an ether-dichloromethane solution ofthe solid afforded dark green block crystals of 1 (31.5 mg, yield 43%). Anal. Calcd. For C21H32F3BBrFe: C, 51.68; H, 6.65; N, 0.00.Found: C, 51.88; H, 7.05; N, 0.00. IR (cm-1): 2949, 1474, 1424, 1381,1186, 1124, 1104, 1081, 1043, 1025, 996, 968, 954, 742, 722, 619, 593,531.

The chemical industry reduces the impact on the environment during synthesis,12126-50-0,Bis(pentamethylcyclopentadienyl)iron(II),I believe this compound will play a more active role in future production and life.

Reference：
Article; Kimata, Hironori; Mochida, Tomoyuki; Journal of Organometallic Chemistry; vol. 895; (2019); p. 23 – 27;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenemethanol, and cas is 1273-86-5, its synthesis route is as follows.

In a Schlenk tube, 1.00 g (4.63 mmol) of ferrocenyl methanol and 0.47 mL(4.7 mmol) of 2,4 pentanedione were dissolved in 8 mL of acetonitrile at room temperature (rt). After 5 min of stirring, 0.125 g (0.23 mmol) of cerium(IV)ammonium nitrate (5% molar) were added. The reaction mixture was stirred for 30 min at rt and then evaporated under reduced pressure. The solid residue was mixed with 5 mL of water and extracted with 10 mL of dichloromethane.The organic phase was dried over MgSO4, filtered off and evaporated under reduced pressure to afford 1.25 g (4.29 mmol, 90% yield) of 1 as an orange oil.

1273-86-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,1273-86-5 ,Ferrocenemethanol, other downstream synthetic routes, hurry up and to see

Reference：
Article; Ahumada, Guillermo; Roisnel, Thierry; Hamon, Jean-Rene; Carrillo, David; Manzur, Carolina; Journal of the Chilean Chemical Society; vol. 58; 4; (2013); p. 1963 – 1966;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

It is a common heterocyclic compound, the iron-catalyst compound, 1,1′-Dibromoferrocene, cas is 1293-65-8 its synthesis route is as follows.

To a solution of 103 g (0.3 mol) of 1 ,1 ‘-dibromoferrocene in 300 ml of THF are added dropwise, at a temperature of < -300C, 120 ml (0.3 mol) of n-BuLi (2.5 M in hexane). The mixture is stirred at this temperature for a further 1.5 hour. The mixture is then cooled to -500C, and 66.2 ml (0.3 mol) of dicyclohexylphosphine chloride are added dropwise sufficiently slowly that the temperature does not rise above -45C. After stirring for a further 10 minutes, the temperature is allowed to rise to room temperature and the mixture is stirred for another hour. After 150 ml of water have been added, the reaction mixture is extracted by shaking with hexane. The organic phases are dried over sodium sulphate and the solvent is distilled off under reduced pressure on a rotary evaporator. The residue is crystallized in ethanol. The product A2 is obtained with a yield of 84% (yellow solid).31P NMR (121.5 MHz, C6D6): delta -8.3 (s); 1H NMR (300 MHz, C6D6): delta 4.41 (m, 2H), 4.26 (m, 2H), 4.23 (m, 2H), 3.97 (m, 2H), 1.20-2.11 (m, 22H).

1293-65-8, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,1293-65-8 ,1,1′-Dibromoferrocene, other downstream synthetic routes, hurry up and to see

Reference：
Patent; SOLVIAS AG; WO2009/65784; (2009); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1287-16-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Ferrocenylacetic acid, cas is 1287-16-7,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.

1) Weigh 1.2mmol ferrocenyl acetic acid and3-H-4-amino-5-mercapto-1,2,4-triazole 1 mmol,Added to a dry 250mL single-necked flask,Then p-toluenesulfonic acid 0.13 mmol,Then 6 mL of DMF was added thereto,The glass rod is stirred to dissolve it.2)The round bottom flask was placed in a microwave reactor,350W under irradiation once every 30s,The duration of irradiation is 3min.After irradiation,cool down.3)Pour it into a crushed beaker,With potassium carbonate and potassium hydroxide pH = 7,Placed overnight,filter,Washed,dry,The crude product of 3-hydro-6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole was obtained,With 80% aqueous ethanol recrystallization,A brown solid,The yield is 82%

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Ferrocenylacetic acid, 1287-16-7

Reference：
Patent; Shaanxi University of Science and Technology; Liu, Yuting; Song, Simeng; Yin, Dawei; Jiang, Shanshan; Liu, Beibei; Yang, Aning; Wang, Jinyu; Lyu, Bo; (13 pag.)CN104231004; (2017); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Ferrocenemethanol, cas is 1273-86-5,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A 48% aqueous solution of tetrafluoroboric acid (0.21 mL, 1.2 mmol) was added to a suspension of ferrocenyl carbinol (1 mmol) and 2mercaptobenzoxazole (1 mmol) in dichloromethane (1 mL) under vigorous stirring. The stirring was continued for 5-15 mL. Then water (10 mL) and diethyl ether (10 mL) were added to the reaction mixture. The resulting mixture was washed with water (2×20 mL), the organic layer was separated and dried with Na2SO4. The solvent was removed under water pump vacuum. 3(Ferrocenylmethyl)benz[d]oxazole-2-thione (1a). Yield 72%. Yellow powder. M.p. 166.8-167.2 C. Found (%): C, 61.97; H, 4.32; N, 4.04; Fe, 15.96. Calculated (%): C, 61.91; H, 4.33; N, N, 4.01; Fe, 15.99. Rf 0.6 (petroleum ether-ethyl acetate, 3 : 1). MS, m/z (Irel(%)): 349 [M]+ (100). 1H NMR, delta: 4.18 (s, 2 H, C5H4); 4.27 (s, 5 H, C5H5); 4.48 (s, 2 H, C5H4); 5.21 (s, 2 H, CH2); 7.15 (d, 1 H, Het, J = 7.6 Hz); 7.22-7.31 (m, 2 H, Het); 7.32 (d, 1 H, Het, J = 7.6 Hz). 13C NMR, delta: 45.66 (CH2), 68.74 (C5H4), 68.96 (C5H5), 69.69 (C5H4), 80.29 (ipsoC5H4), 109.81 (Het), 110.34 (Het), 124.17 (Het), 124.75 (Het), 131.51 (Het), 147.05 (Het), 180.06 (C=S).

The chemical industry reduces the impact on the environment during synthesis,1273-86-5,Ferrocenemethanol,I believe this compound will play a more active role in future production and life.

Reference：
Article; Osipova, E. Yu.; Ivanova; Rodionov; Korlyukov; Arkhipov; Simenel; Russian Chemical Bulletin; vol. 65; 12; (2016); p. 2868 – 2872; Izv. Akad. Nauk, Ser. Khim.; vol. 65; 12; (2016); p. 2868 – 2872,5;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-82-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Aminoferrocene, cas is 1273-82-1,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.

5) 402 mg (2.0 mmol) of FcNH2 was added to the above system and the reaction was continued for 16 hours; The solvent was evaporated under reduced pressure, The residue was extracted with CH2Cl2, Thin layer chromatography was carried out using methylene chloride / petroleum ether = 1: 2 (v / v) as a developing solvent, Collect the red main ribbon,To give a model 1 (325 mg) Yield 28%.

The chemical industry reduces the impact on the environment during synthesis,1273-82-1,Aminoferrocene,I believe this compound will play a more active role in future production and life.

Reference：
Patent; Nankai University; Song, Licheng; Lu, Yu; Peng, Fei; Yang, Xiyue; (6 pag.)CN105601678; (2016); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion