Related Products of 1273-86-5, hemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. In a document type is Article, molecular formula is C11H3FeO, molecular weight is 206.99, and a compound is mentioned, 1273-86-5, Ferrocenemethanol, introducing its new discovery.
A direct synthesis of alpha-alkylated arylacetamides from arylacetonitriles and primary alcohols has been accomplished for the first time. In the presence of the rhodium complex [Rh(cod)Cl]2/triphenylphosphine/potassium hydroxide system, the desired alpha-alkylated arylacetamides were obtained in 74-92% yield under microwave conditions. The experimental results in this paper are in sharp contrast with previous reports, where the coupling of arylacetonitriles and primary alcohols produced the alpha-alkylated arylacetonitriles. Mechanistic investigations show that arylacetonitriles are first alpha-alkylated with primary alcohols to produce alpha-alkylated arylacetonitriles, which are further hydrated with the water resulting from the alpha-alkylation step to produce alpha-alkylated arylacetamides. More importantly, this research shows the potential of developing completely atom-economical reactions that involve the hydrogen autotransfer (or hydrogen borrowing) process.
In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool.Related Products of 1273-86-5. In my other articles, you can also check out more blogs about 1273-86-5
Reference：
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion