As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO388,mainly used in chemical industry, its synthesis route is as follows.,1271-42-7
To a methylene chloride solution (3.6 mL) of ferrocenecarboxylic acid (manufactured by Tokyo Kasei) (237 mg),Triethylamine (102 mg) and oxalyl chloride (767 mg) were added under an argon atmosphere, and the mixture was stirred at room temperature for 5 hours. After the reaction solution was concentrated under reduced pressure, compound 3 (161 mg), 4-dimethylaminopyridine (26 mg), triethylamine (305 mg), and tetrahydrofuran (8.6 mL) were added. Stirred for hours. The reaction solution was poured into methylene chloride / water, and the organic layer was washed with saturated aqueous sodium chloride.The extract was washed with a solution, dried over sodium sulfate, and then concentrated under reduced pressure. Silica gel concentrated residuePurified by column chromatography (developing solvent: ethyl acetate / hexane = 1/5) and obtained crude productIs purified by size exclusion chromatography and washed with pentane to give the compound.Compound FcD (157 mg) was obtained.
With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenecarboxylic acid,belong iron-catalyst compound
Reference£º
Patent; The University of Tokyo; Aita, Takuzo; Ito, Yoshimitsu; Toku, Yongxiang; (19 pag.)JP2019/151597; (2019); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion