1287-16-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Ferrocenylacetic acid, cas is 1287-16-7,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.
In a 50mL three neck round bottom flask, ferroceneacetic acid (0.0600g, 0.25mmol), oxalyl chloride (21.8muL, 0.25mmol), pyridine (20.1muL, 0.25mmol) and 4-(1H-pyrrol-1yl)phenol (0.0398g, 0.25mmol) were reacted in 10mL of dichloromethane (DCM) under nitrogen atmosphere at room temperature. The reaction was carried out for 12h to get 4(1H-pyrrol-1-yl)phenyl ferroceneacetylate. After that period three consecutive washing with 0.01M HCl were carried out. The organic phase was then dried over sodium sulfate. The product was separated by column chromatography using silica gel and DCM as mobile phase. Fc-CH2CO2-Ph-4-Py was isolated in 62% yield.
The chemical industry reduces the impact on the environment during synthesis,1287-16-7,Ferrocenylacetic acid,I believe this compound will play a more active role in future production and life.
Reference£º
Article; Perez, Wanda I.; Soto, Yarelys; Ortiz, Carmen; Matta, Jaime; Melendez, Enrique; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 471 – 479;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion