Category: 102-54-5

As a common heterocyclic compound, it belong iron-catalyst compound,Ferrocene,102-54-5,Molecular formula: C10Fe,mainly used in chemical industry, its synthesis route is as follows.,102-54-5

To a solution of ferrocene (1; 5.00 g, 26.87 mmol) in anhydrous CH 2 Cl 2(30 mL), a solution of acetyl chloride (2.01 mL, 28.21 mmol) and AlCl 3(3.94 g, 29.55 mmol) in anhydrous CH 2 Cl 2 (40 mL) was added at 0 C.The reaction temperature was allowed to rise to r.t., and the dark-vio-let solution was stirred for 2 h. The reaction was quenched by addi-tion of ice-cold water (70 mL) at 0 C and the mixture was extractedwith CH 2 Cl 2 (3 ¡Á 70 mL). The collected organic layers were washedwith a solution of Na 2 CO 3 (50 mL), dried over Na 2 SO 4 , filtrated and thesolvent was removed under reduced pressure. Crude product (dark-orange solid) was purified by chromatography on SiO 2 (hexanes/EtOAc = 4:1; R f = 0.3) to afford target product 2.Yield: 4.45 g (73%); orange solid; mp 85-86 C (lit. 20 85-86 C).1 H NMR (300 MHz, CDCl 3 ): delta = 4.78-4.76 (m, 2 H), 4.55-4.42 (m, 2 H),4.20 (s, 5 H), 2.40 (s, 3 H).NMR spectra are in agreement with those of the commercially avail-able product.

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocene,belong iron-catalyst compound

Reference£º
Article; Plevova, Kristina; Mudrakova, Brigita; ?ebesta, Radovan; Synthesis; vol. 50; 4; (2018); p. 760 – 763;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

A common heterocyclic compound, the iron-catalyst compound, name is Ferrocene,cas is 102-54-5, mainly used in chemical industry, its synthesis route is as follows.

To a three-neck flask, were added10.0 g of dry ferrocene (53.76 mmol) 150 mL of CH2Cl2. Then 39.2 g of triethylorthoformate (264.34) was added dropwise to the mixture with stirring. Afterthe ferrocene was completely dissolved, 30.0 g of mmol anhydrous AlCl3wasslowly added, and the reaction mixture was stirred at room temperature for4 h. Then the reaction was quenched with sodium hydrosulphite saturatedsolution (200 mL) and the mixture was extracted with diethyl ether (200 mL).After concentrated under reduced pressure, the residue was purified by chro-matography on silica gel (petroleum ether:ethyl acetate = 5:1) to afford 7 g redsolid with the yield of 70%.1H NMR (400 MHz, CDCl3) = 4.28 (s, 5H), 4.61 (s,2H); 4.80 (s, 2H), 9.96 (s, 1H).

As the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Article; I?ik, U?ur; Aydemir, Murat; Meric, Nermin; Durap, Feyyaz; Kayan, Cezmi; Temel, Hamdi; Baysal, Akin; Journal of Molecular Catalysis A: Chemical; vol. 379; (2013); p. 225 – 233;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

A common heterocyclic compound, the iron-catalyst compound, name is Ferrocene,cas is 102-54-5, mainly used in chemical industry, its synthesis route is as follows.

(1) Synthesis of ferrocene formaldehyde: under the protection of the helium gas, in the ice-bath cooling, constant pressure in the funnel 14.6 g (0.2 muM) DMF dimethyl formamide in 10 minutes into the 18.6 g (0.1 muM) ferrocene 75 ml dry chloroform solution; then, 30.6 g (0.2 muM) phosphorus oxychloride in a half-hour in dripped into the reaction bottle, the completion of the dropping, the oil bath temperature to 60 C, heating and stirring 20 hr, the oil bath temperature is still lower than the 60 C; the completion of the reaction, the reaction mixture is poured into ice water, the solid is most unreacted ferrocene, filtering to filter the solid insoluble matter, the filtrate magnesium carbonate powder carefully neutralized, then circulating extraction device repeatedly extraction reaction mixture, all of the extracts combined, water washing, the organic layer using sodium carbonate drying, to remove the solvent to obtain the crude product 18.21 g, dichloromethane is used for – hexane recrystallize to get red brown crystal 15.0 g, yield of 72.4%.

As the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Patent; Shandong Yuangen Petrochemical Co., Ltd.; Qiao Liang; Yuan Junzhou; Song Laigong; He Jingsong; Liu Shanshan; (7 pag.)CN104710482; (2018); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

102-54-5, Ferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ferrocene (0.500 g, 2.69 mmol) and acetic anhydride (1.7 mL) were dissolved in acid, phosphoric acid aqueous solution (85% in 0 oC, 0.53 g, were placed 0.30 mL, 4.8 mmol). After heating the reaction mixture under reflux for 15 minutes, it poured into a beaker containing 20 g of ice. After all the ice is melted were placed in a saturated aqueous solution of sodium bicarbonate until air bubbles are no longer generated. The reaction mixture was cooled to 0 dried under reduced pressure gave filtered while washing the resulting solid with water to give a red solid Compound 1b. (0.598 g, 97%).

As the paragraph descriping shows that 102-54-5 is playing an increasingly important role.

Reference£º
Patent; Diatech Korea Co. Ltd.; Sogang University Research Foundation; Moon, PongJin; Oh, HaNa; Kang, NaNa; Cheon, AeRan; Park, Gye Shin; Park, Hyeong Soon; Pang, Choo Young; (31 pag.)KR101583811; (2016); B1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

102-54-5, Ferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ferrocenecarboxaldehyde was prepared from ferrocene according to the literature.10 Phosphorus oxychloride (50mL, 536mmol) was added dropwise to the dimethylformamide (39.0g, 536mmol) at 0C and the resulting mixture was stirred for 30min at this temperature under a nitrogen atmosphere. Next ferrocene (50.0g, 268mmol) in dry chloroform (250mL) was added dropwise to the mixture for 30min at 0C. After completion of the addition, the reaction mixture was kept stirring for 28h with heating at 55-60C on an oil bath, taking care that the temperature did not exceed 60C. The reaction mixture was then cooled to room temperature and neutralized carefully with an aqueous saturated Na2CO3 solution and then extracted repeatedly with the dichloromethane. The combined organic layer was dried over anhydrous Na2SO4, filtered and the solvent was evaporated under reduced pressure. The residue was purified through silica gel column chromatography using hexane/ ethyl acetate mixture (95:05) as eluent to give ferrocenecarboxaldehyde 1 in 55% yield (31.7g) as a reddish brown solid. (mp: 122C, lit.10 123C); IR (KBr, cm-1): 3093, 2837, 2760, 1683, 1447; 1H NMR (400MHz, CDCl3): deltaH 9.95 (s, 1H); 4.80-4.60 (m, 4H), 4.27 (s, 5H); 13C NMR (100MHz, CDCl3): deltaC 193.63, 79.49, 73.33, 69.78; HRMS-ESI (m/z): [M+H]+ Found 215.0157 and calculated 215.0159 for C11H11FeO.

The synthetic route of 102-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Achari, Kamsali Murali Mohan; Ramanathan, Chinnasamy Ramaraj; Tetrahedron Asymmetry; vol. 28; 6; (2017); p. 830 – 836;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

The iron-catalyst compound, cas is 102-54-5 name is Ferrocene, mainly used in chemical industry, its synthesis route is as follows.

Weigh 5.59g (30mmol) ferrocene was added to 250mL two-necked flask, and then weighed 24mL (254mmol) of acetic anhydride was added to the flask, and then weighed 7mL (including H3PO4 121mmol) 85% phosphoric acid was added slowly to the flask.Temperature was raised to 75 ~ 80C for about 10min, then the flask was immediately cooled in an ice bath, was added to the flask to about 30mL of ice water.After a short cooling with 25% NaOH solution to neutral, a large tan solid precipitated, cooling was continued for some time and the filter cake was washed with an amount of ice water, dry.The crude product is purified by column chromatography (dichloromethane / petroleum ether (60-90) eluting the solvent was evaporated to give an orange solid ferrocene ethyl ketone product 5.30g, yield 77.1% (ferrocene meter ), melting point 83 ~ 85C.

As the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Patent; Huazhong Agricultural University; Ma, Jingzhong; Yan, Xinwen; Ma, Zhonghua; Jiang, Hong; Yang, Qiuhong; He, Mengli; (18 pag.)CN103626805; (2016); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.102-54-5,Ferrocene,as a common compound, the synthetic route is as follows.

To a three-neck flask, were added10.0 g of dry ferrocene (53.76 mmol) 150 mL of CH2Cl2. Then 39.2 g of triethylorthoformate (264.34) was added dropwise to the mixture with stirring. Afterthe ferrocene was completely dissolved, 30.0 g of mmol anhydrous AlCl3wasslowly added, and the reaction mixture was stirred at room temperature for4 h. Then the reaction was quenched with sodium hydrosulphite saturatedsolution (200 mL) and the mixture was extracted with diethyl ether (200 mL).After concentrated under reduced pressure, the residue was purified by chro-matography on silica gel (petroleum ether:ethyl acetate = 5:1) to afford 7 g redsolid with the yield of 70%.1H NMR (400 MHz, CDCl3) = 4.28 (s, 5H), 4.61 (s,2H); 4.80 (s, 2H), 9.96 (s, 1H).

The synthetic route of 102-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; I?ik, U?ur; Aydemir, Murat; Meric, Nermin; Durap, Feyyaz; Kayan, Cezmi; Temel, Hamdi; Baysal, Akin; Journal of Molecular Catalysis A: Chemical; vol. 379; (2013); p. 225 – 233;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocene, cas is 102-54-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.

A mixture of 5.3g (28mmol) ferrocene and 60mL chloroform was placed in a 50mL three-neck flask and kept at-5 to-10C. Afterward, 10.5mL phosphorus oxychloride dissolved in 15mL DMF was added for 1.5h. The resulting reaction mixture was refluxed for 12h. After solvent removal, the product was poured into 100mL ice water and filtered. The filtrate was neutralized to pH 8-9 using NaOH (10%, w/v) and then extracted with ether. The organic layer was washed with water and dried over anhydrous MgSO4. After removal of the solvent, the crimson solid was recrystallized from n-hexane. The purified product (1) weighed 2.3g (79% yield). 1H NMR(CDCl3): delta, 9.95 (s, 1H, HC=O), 4.79-4.80 (d, 2H, Cp-rings), 4.60-4.61(d, 2H, Cp-rings), 4.28(s, 5H, Cp?-rings). MS(ESI), m/z: 215.0 (M+) FT-IR (KBr): upsilon (cm-1) 1681(C=O).

With the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Article; Jia, Jianhong; Cui, Yanhong; Li, Yujin; Sheng, Weijian; Han, Liang; Gao, Jianrong; Dyes and Pigments; vol. 98; 2; (2013); p. 273 – 279;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocene, cas is 102-54-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.

Ferrocene (0.500 g, 2.69 mmol) and acetic anhydride (1.7 mL) were dissolved in acid, phosphoric acid aqueous solution (85% in 0 oC, 0.53 g, were placed 0.30 mL, 4.8 mmol). After heating the reaction mixture under reflux for 15 minutes, it poured into a beaker containing 20 g of ice. After all the ice is melted were placed in a saturated aqueous solution of sodium bicarbonate until air bubbles are no longer generated. The reaction mixture was cooled to 0 dried under reduced pressure gave filtered while washing the resulting solid with water to give a red solid Compound 1b. (0.598 g, 97%).

With the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Patent; Diatech Korea Co. Ltd.; Sogang University Research Foundation; Moon, PongJin; Oh, HaNa; Kang, NaNa; Cheon, AeRan; Park, Gye Shin; Park, Hyeong Soon; Pang, Choo Young; (31 pag.)KR101583811; (2016); B1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocene, cas is 102-54-5, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.

The alcohol 1b was synthesized by acylation offerrocene (Aldrich) with acetic anhydride in presence of BF3Et2O21followed by reduction of the resulting acetylferrocene withNaBH4.22

With the rapid development of chemical substances, we look forward to future research findings about 102-54-5

Reference£º
Article; Trofimov, Boris A.; Oparina, Ludmila A.; Tarasova, Olga A.; Artem’ev, Alexander V.; Kobychev, Vladimir B.; Gatilov, Yuriy V.; Albanov, Alexander I.; Gusarova, Nina K.; Tetrahedron; vol. 70; 35; (2014); p. 5954 – 5960;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion