Category: 12093-10-6

12093-10-6, Ferrocenecarboxaldehyde is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,12093-10-6

General procedure: O-amino amides 1a-e (1 equiv.) and carbonyl compounds 2a-o (1.2 equiv.) were microwave irradiated (standard mode) in the presence of Phosphotungstic acid/HPW (50 % w/w) at 200 W for 3 min. After the completion of the reaction (Monitored by TLC), HPW was filtered off using celite bed/Silica bed. The crude product was purified on silica gel a column chromatography to afford the corresponding spiro and cyclic quinazolinones 3a-3n, 4a-4h, and 5a, 5b in very good yields except compounds 6a and 7a were obtained in poor yields (Eluent: n-Hexane /EtOAc). All the compounds 3a-3n, 4a-4h, 5a-b, 6a and 7a were thoroughly characterized by 1H NMR, 13CNMR, FTIR and HRMS.

The synthetic route of 12093-10-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Novanna, Motakatla; Kannadasan, Sathananthan; Shanmugam, Ponnusamy; Tetrahedron Letters; vol. 60; 2; (2019); p. 201 – 206;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

12093-10-6, Ferrocenecarboxaldehyde is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,12093-10-6

General procedure: To a stirred suspension of p-toluenesulfonyl hydrazide (1eq.) in water (12mL) and three drops of HCl 32%, the formyl or acetyl organometallic precursor (1eq.) was added. The resulting mixture was stirred for 18h at room temperature. The precipitate obtained was washed with water (2¡Á10mL) and dried under vacuum. The hydrazone derivatives were recrystallized from acetone/hexane (1:5) at -18C

12093-10-6 Ferrocenecarboxaldehyde 11138449, airon-catalyst compound, is more and more widely used in various.

Reference£º
Article; Concha, Camila; Quintana, Cristobal; Klahn, A. Hugo; Artigas, Vania; Fuentealba, Mauricio; Biot, Christophe; Halloum, Iman; Kremer, Laurent; Lopez, Rodrigo; Romanos, Javier; Huentupil, Yosselin; Arancibia, Rodrigo; Polyhedron; vol. 131; (2017); p. 40 – 45;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

12093-10-6, Ferrocenecarboxaldehyde is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

An ethanolic solution (10 ml) of ferrocenyl carboxyaldehyde (21 mg, 0.1 mmol) was taken in a round bottomed flask and acetyl cymantrene (28 mg, 0.1 mmol) was added under stirring condition. Two equivalents of sodium hydroxide in ethanol solution was then added to the reaction mixture and stirring was continued at room temperature under inert atmosphere for 3 h. The reaction was continuously monitored by TLC and on completion of the reaction the solution was dried under vacuum and the residue was dissolved in dichloromethane solvent and subjected to chromatographic work-up using column chromatography. Elution with dichloromethane/hexane (30:70 v/v) solvent mixture separated the following compounds in the order of elution: [(CO)3Mn(eta5-C5H4)COCH3], [(eta5-C5H5)Fe(eta5-C5H4CHO)] and violet colored compound [(eta5-C5H4)Mn(CO)3COCH=CH(eta5-C5H4)Fe(eta5-C5H5)] (1). {Yield: 32 mg (73%)} 1: Anal. calcd. (found): C, 57.01 (57.23); H, 3.39 (3.34). IR(nuCO, cm-1,CH2Cl2) 2022.8 (vs), 1937 (vs br), 1653 (s), 1586 (s). 1H NMR (delta, CDCl3): 4.2 (s, eta5-C5H5, 5H), 4.52 (t, eta5-C5H4, 2H), 4.6 (t, eta5-C5H4, 2H), 4.9 (t, eta5-C5H4, 2H), 5.55 (t, eta5-C5H4, 2H), 6.58 (d, J = 15 Hz, CH=, 1H), 7.78 (d, J = 15 Hz, =CH, 1H). 13C NMR (delta, CDCl3): 69.16 (eta5-C5H5), 69.95 (eta5-C5H4), 71.66 (eta5-C5H4), 78.47 (eta5-C5H4), 83.61 (eta5-C5H4), 86.59 (eta5-C5H4), 93.78 (eta5-C5H4), 117.41 (=CH), 146.38 (=CH), 185.29 (-C=O). UV-Vis. (lambda (nm), CH2Cl2) = 321, 384, 502. MS (ESI): m/z 443 (M + 1)+., 12093-10-6

As the paragraph descriping shows that 12093-10-6 is playing an increasingly important role.

Reference£º
Article; Mishra, Sasmita; Tirkey, Vijaylakshmi; Ghosh, Avishek; Dash, Hirak R.; Das, Surajit; Shukla, Madhulata; Saha, Satyen; Mobin, Sheikh M.; Chatterjee, Saurav; Journal of Molecular Structure; vol. 1085; (2015); p. 162 – 172;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenecarboxaldehyde, cas is 12093-10-6, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,12093-10-6

Ferrocene carboxyl aldehyde (0.100 g, 0.467 mmol) was dissolved in ethanol (8 mL), was added slowly in small portions sodium borohydride (0.090 g, 2.4mmol) at 0 . The reaction mixture was stirred at ambient temperature for 3 hours. It was add water (3mL) and dichloromethane (10 mL) in turn to complete the reaction.The organic layer was separated and the remaining water layer was extracted three times with dichloromethane (15mL x 3). The combined organic layer is washed with a saturated aqueous sodium chloride solution, placed into the over anhydrous sodium sulfate, filtered under reduced pressure. After removal of all the solvent in the filtrate under reduced pressure was purified by column chromatography (hexane: ethyl acetate: methanol = 15: 5: 1) to give the compound 2a to give a yellow solid. (0.090 g, 89%)

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenecarboxaldehyde,belong iron-catalyst compound

Reference£º
Patent; Diatech Korea Co. Ltd.; Sogang University Research Foundation; Moon, PongJin; Oh, HaNa; Kang, NaNa; Cheon, AeRan; Park, Gye Shin; Park, Hyeong Soon; Pang, Choo Young; (31 pag.)KR101583811; (2016); B1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belong iron-catalyst compound,Ferrocenecarboxaldehyde,12093-10-6,Molecular formula: C11H10FeO,mainly used in chemical industry, its synthesis route is as follows.,12093-10-6

General procedure: (i-Pr-Pybox)ZnCl2 (2b) (10.9 mg, 0.025 mM, 0.1 equiv) was added in H2O (0.5 mL), thenferrocenecarboxaldehyde (53.4 mg, 0.25 mM, 1.0 equiv) and activated methylene compound(0.5 mM, 2.0 equiv) were added. The mixture was stirred at room temperature forfew minutes, after which the crude reaction mixture was loaded directly onto a column ofsilica gel and purified by column chromatography to give the solid.

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenecarboxaldehyde,belong iron-catalyst compound

Reference£º
Article; Jia, Wei-Guo; Li, Dan-Dan; Zhang, Hui; Dai, Yuan-Chen; Sheng, En-Hong; Journal of Coordination Chemistry; vol. 68; 2; (2015); p. 220 – 228;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belong iron-catalyst compound,Ferrocenecarboxaldehyde,12093-10-6,Molecular formula: C11H10FeO,mainly used in chemical industry, its synthesis route is as follows.,12093-10-6

An ethanolic solution (10 ml) of ferrocenyl carboxyaldehyde (21 mg, 0.1 mmol) was taken in a round bottomed flask and acetyl cymantrene (28 mg, 0.1 mmol) was added under stirring condition. Two equivalents of sodium hydroxide in ethanol solution was then added to the reaction mixture and stirring was continued at room temperature under inert atmosphere for 3 h. The reaction was continuously monitored by TLC and on completion of the reaction the solution was dried under vacuum and the residue was dissolved in dichloromethane solvent and subjected to chromatographic work-up using column chromatography. Elution with dichloromethane/hexane (30:70 v/v) solvent mixture separated the following compounds in the order of elution: [(CO)3Mn(eta5-C5H4)COCH3], [(eta5-C5H5)Fe(eta5-C5H4CHO)] and violet colored compound [(eta5-C5H4)Mn(CO)3COCH=CH(eta5-C5H4)Fe(eta5-C5H5)] (1). {Yield: 32 mg (73%)} 1: Anal. calcd. (found): C, 57.01 (57.23); H, 3.39 (3.34). IR(nuCO, cm-1,CH2Cl2) 2022.8 (vs), 1937 (vs br), 1653 (s), 1586 (s). 1H NMR (delta, CDCl3): 4.2 (s, eta5-C5H5, 5H), 4.52 (t, eta5-C5H4, 2H), 4.6 (t, eta5-C5H4, 2H), 4.9 (t, eta5-C5H4, 2H), 5.55 (t, eta5-C5H4, 2H), 6.58 (d, J = 15 Hz, CH=, 1H), 7.78 (d, J = 15 Hz, =CH, 1H). 13C NMR (delta, CDCl3): 69.16 (eta5-C5H5), 69.95 (eta5-C5H4), 71.66 (eta5-C5H4), 78.47 (eta5-C5H4), 83.61 (eta5-C5H4), 86.59 (eta5-C5H4), 93.78 (eta5-C5H4), 117.41 (=CH), 146.38 (=CH), 185.29 (-C=O). UV-Vis. (lambda (nm), CH2Cl2) = 321, 384, 502. MS (ESI): m/z 443 (M + 1)+.

With the synthetic route has been constantly updated, we look forward to future research findings about Ferrocenecarboxaldehyde,belong iron-catalyst compound

Reference£º
Article; Mishra, Sasmita; Tirkey, Vijaylakshmi; Ghosh, Avishek; Dash, Hirak R.; Das, Surajit; Shukla, Madhulata; Saha, Satyen; Mobin, Sheikh M.; Chatterjee, Saurav; Journal of Molecular Structure; vol. 1085; (2015); p. 162 – 172;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

A common heterocyclic compound, the iron-catalyst compound, name is Ferrocenecarboxaldehyde,cas is 12093-10-6, mainly used in chemical industry, its synthesis route is as follows.

General procedure: In a typical procedure, 1.39 mmol of 2?-hydroxyacetophenone (for 1 and 3) or 2?-hydroxy-4?-methoxyacetophenone (for 2 and 4) were dissolved in 40 ml of methanol. To this solution, 4 equivalent of potassium hydroxide were added and stirred for 15 min at room temperature. Then, 1.40 mmol of the appropriate ferrocenecarboxaldehyde derivative, (i.e. 1-ferrocenecarboxaldehyde for 1 and 2 or 1,1-ferrocenedicarboxaldehyde for 3 and 4) were added. The mixture was stirred during three days at room temperature. Then, methanol was evaporated in vacuum (rotary evaporator) and the crude reaction mixture was submitted to column chromatography (silica gel 60, Ethyl acetate: Hexane = 3:10 v/v). (E)-3-Ferrocenyl-1-(2-hydroxyphenyl)-prop-2-en-1-one, (1). Yield 65% (605 mg), mp. 157-159.4 C. IR (KBr) cm-1: 3456 (OH), 3105 (C-H), 3086 (C-H), 1630 (C=O). 1H NMR (CDCl3, 400 MHz): delta 4.22 (5H, s, C5H5), 4.56 (2H, s, H-beta-C5H4), 4.65 (2H, s, H-alpha -C5H4), 6.95 (1H, t, J = 7.2 Hz, Harom), 7.26 (1H, d, J = 15 Hz, =CH), 7.45 (1H, t, J = 7.2 Hz, Harom), 7.88 (1H, d, J = 9.1 Hz, Harom), 7.92 (1H, d, J = 15 Hz, =CH), 13.08 (1H, s, OH). 13C NMR (CDCl3, 400 MHz): delta: 31.34, 69.51, 69.71, 70.36, 72.27, 117.15, 119.00, 119.10, 129.79, 136.30, 148.36, 164.03, 193.17. Uv-vis: 528 nm (704.5 cm-1M-1), 340 nm (8400 cm-1M-1). Analysis calculated for C19H16O2Fe: C, 68.70; H, 4.86. Found: C, 68.22; H, 4.76.

As the rapid development of chemical substances, we look forward to future research findings about 12093-10-6

Reference£º
Article; Trujillo, Alexander; Ocayo, Fernanda; Artigas, Vania; Santos, Juan C.; Jara-Ulloa, Paola; Kahlal, Samia; Saillard, Jean-Yves; Fuentealba, Mauricio; Escobar, Carlos A.; Tetrahedron Letters; vol. 58; 5; (2017); p. 437 – 441;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12093-10-6,Ferrocenecarboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of KOH (12.0 equiv.)in absolute EtOH (100 mL) cooled to 0 C in an ice-bath were added dropwise a solution of thecorresponding acetophenone (1.0 equiv.) and aldehyde (1.0 equiv.) in EtOH (20 mL). The reactionmixture was stirred at 0 C for 1 h and then at room temperature for 72 h under a nitrogen atmosphereor until TLC analysis indicated complete consumption of starting material. The resulting mixture wasthen poured into ice-water (100 mL) and acidified to pH 3-4 with 3 M HCl. The aqueous solution wasextracted with CHCl3 (3 100 mL) and the combined organic layer was washed with satd NaHCO3(2 100 mL), brine (2 100 mL), dried over anhydrous MgSO4, filtered and the solvent removedunder reduced pressure. The crude residue was purified by flash column chromatography over silicaand/or recrystallized from MeOH or absolute EtOH to afford the corresponding chalcones.

As the paragraph descriping shows that 12093-10-6 is playing an increasingly important role.

Reference£º
Article; Sum, Tze Han; Sum, Tze Jing; Galloway, Warren R. J. D.; Collins, Suil; Twigg, David G.; Hollfelder, Florian; Spring, David R.; Molecules; vol. 21; 9; (2016);,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

The iron-catalyst compound, cas is 12093-10-6 name is Ferrocenecarboxaldehyde, mainly used in chemical industry, its synthesis route is as follows.

General procedure: To a suspension of methyltriphenylphosphonium bromide (1equiv.) in dry THF (100 mL), under nitrogen atmosphere at room temperaturewas added potassium tert-butoxide (7.0 equiv.). The solutionwas stirred for 1 h and then a solution of the aldehyde (1 equiv.) indry THF (30 mL) was added slowly. The mixture was stirred at roomtemperature for 12 h andwas evaporated to dryness. The unreacted potassiumtert-butoxide was quenched with saturated NH4Cl solution(10 mL). The reaction mixture was then extracted with CHCl3(200 mL), washed with water (2 ¡Á 200 mL), brine (100 mL) and then dried over anhydrous Na2SO4. Evaporation of the organic layer gave aresidue, which was purified by column chromatography using hexaneas the eluting solvent to give the corresponding vinyl compounds.

As the rapid development of chemical substances, we look forward to future research findings about 12093-10-6

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Article; Ravivarma, Mahalingam; Kumar, Kaliamurthy Ashok; Rajakumar, Perumal; Pandurangan, Arumugam; Journal of Molecular Liquids; vol. 265; (2018); p. 717 – 726;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

The iron-catalyst compound, cas is 12093-10-6 name is Ferrocenecarboxaldehyde, mainly used in chemical industry, its synthesis route is as follows.

General preparation of ferrocenyl chalcones: Ferrocene carboxaldehyde (1 eq) and the appropriate 2-hydroxyacetophenone (1 eq) were dissolved in absolute ethanol (40 ml.) in a 100 ml. two necked round bottom flask. After stirring the mixture 10 to 15 min. at room temperature, sodium hydroxide (3 eq) was added, and the solution was stirred overnight at room temperature, or 2-3h at reflux. The mixture was poured into water (100 ml.) and hydrochloric acid (12 M, 15 ml_), extracted with dichloromethane (3 x 50 ml_), and washed with water. The organic phase was dried over magnesium sulfate, filtered, and the solvent removed by evaporation. The product was purified by silica gel chromatography, using a mixture of petroleum ether/dichloromethane 4:1 as an eluent, and again using HPLC in acetonitrile/water (90:10). After HPLC purification, the acetonitrile was removed under reduced pressure and the aqueous phase extracted with dichloromethane.

With the rapid development of chemical substances, we look forward to future research findings about 12093-10-6

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); HILLARD, Elizabeth; CHABOT, Guy; MONSERRAT, Jean-Philippe; JAOUEN, Gerard; TIWARI, Keshri Nath; DE MONTIGNY, Frederic; NEAMATI, Nouri; WO2011/107572; (2011); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion