1287-16-7 | - Page 3 of 8

Application of 1,5-Diphenylpenta-1,4-dien-3-one

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Ferrocenylacetic acid, 1287-16-7

1287-16-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Ferrocenylacetic acid, cas is 1287-16-7,the iron-catalyst compound, it is a common compound, a new synthetic route is introduced below.

1) 1.1 mmol of ferrocenyl acetic acid and 1 mmol of 3- (3-methylphenyl) -4-amino-5-mercapto-1,2,4-triazole were weighed out,Added to a dry 250mL single-necked flask,Then p-toluenesulfonic acid 0.14 mmol,Then 5 mL of DMF was added thereto,The glass rod is stirred to dissolve it.2)The round bottom flask was placed in a microwave reactor,360W under irradiation once every 30s,Irradiation duration of 3.5min.After irradiation,cool down.3)Pour it into a crushed beaker,With potassium carbonate and potassium hydroxide pH = 7,Placed overnight,filter,Washed,dry,The crude product of 3- (3-methylphenyl) -6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole was obtained,Using a solvent of DMF and absolute ethanol in a volume ratio of 2: 1 mixed solvent,The crude product was recrystallized,That is, a brown solid,The yield is 85%

Reference£º
Patent; Shaanxi University of Science and Technology; Liu, Yuting; Song, Simeng; Yin, Dawei; Jiang, Shanshan; Liu, Beibei; Yang, Aning; Wang, Jinyu; Lyu, Bo; (13 pag.)CN104231004; (2017); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Extracurricular laboratory: Synthetic route of 1287-16-7

The chemical industry reduces the impact on the environment during synthesis,1287-16-7,Ferrocenylacetic acid,I believe this compound will play a more active role in future production and life.

11-O-Nitro-azithromycin (0.25 mmol) was dissolved in dry dichloromethane (5 mL). To this was added EDCI (2 eq., 0.5 mmol) and 2-ferrocenyl acetic acid (1.1 eq., 0.28 mmol). The reaction was stirred overnight at room temperature. The solvent was removed in vacuo and the resulting white amorphous foam. The resulting crude product was purified by column chromatography with a gradient starting at 10 % of acetone in cyclohexane (0.2% Et3N).

The chemical industry reduces the impact on the environment during synthesis,1287-16-7,Ferrocenylacetic acid,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; SYNOVO GMBH; PIETRZIK, Nikolas; BURNET, Michael, W.; BAEUERLEIN, Christiane; EGGERS, Mary; GUSE, Jan-hinrich; HAHN, Ulrike; STRASS, Simon; (0 pag.)WO2018/161039; (2018); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

The important role of 1287-16-7

1287-16-7, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,1287-16-7 ,Ferrocenylacetic acid, other downstream synthetic routes, hurry up and to see

It is a common heterocyclic compound, the iron-catalyst compound, Ferrocenylacetic acid, cas is 1287-16-7 its synthesis route is as follows.

1)1 mmol of ferrocenyl acetic acid and 1 mmol of 3- (4-chlorophenoxymethylene) -4-amino-5-mercapto-1,2,4-triazole were weighed out,Added to a dry 250mL single-necked flask,Then 0.1 mmol p-toluenesulfonic acid,Then 5 mL of DMF was added thereto,The glass rod is stirred to dissolve it.2)The round bottom flask was placed in a microwave reactor,350W under irradiation once every 30s,The duration of irradiation is 3min.After irradiation,cool down.3)Pour it into a crushed beaker,With potassium carbonate and potassium hydroxide pH = 7,Placed overnight,filter,Washed,dry,The crude product of 3- (4-chlorophenoxymethylene) -6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole ,The crude product was recrystallized using 80% aqueous ethanol,That is, a brown solid,The yield is 85%

Extracurricular laboratory: Synthetic route of 1287-16-7

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenylacetic acid, and cas is 1287-16-7, its synthesis route is as follows.

1)1.1 mmol of ferrocenyl acetic acid and 1 mmol of 3-propyl-4-amino-5-mercapto-1,2,4-triazole were weighed out,Added to a dry 250mL single-necked flask,Then 0.1 mmol p-toluenesulfonic acid,Then 5 mL of DMF was added thereto,The glass rod is stirred to dissolve it.2)The round bottom flask was placed in a microwave reactor,350W under irradiation once every 30s,The duration of irradiation is 3min.After irradiation,cool down.3)Pour it into a crushed beaker,With potassium carbonate and potassium hydroxide pH = 7,Placed overnight,filter,Washed,dry,The crude product of 3-propyl-6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole was obtained,With 80% aqueous ethanol recrystallization,A brown solid,The yield was 84%

The important role of Ferrocenylacetic acid

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

Name is Ferrocenylacetic acid, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1287-16-7, its synthesis route is as follows.,1287-16-7

General procedure: A mixture of ferrocene acetic acid (1 mmol), the required 3-substituted-4-amino-5-mercapto-1,2,4-triazole(1 mmol), and p-toluenesulfonic acid (0.1 mmol) in DMF(10 mL) was stirred until a homogeneous solution was obtained. The mixture was exposed to microwave irradiation for about 3 min at 350 W and then cooled and poured into crushed ice. The mixture was adjusted to pH 7 with potassium carbonate and potassium hydroxide and then kept overnight at room temperature. The crude product was filtered off, dried and recrystallized from 80% ethanol to afford the pure product (Scheme 1). 6-Ferrocene methylene-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (1a) Brown solid; Yield: 82%; m.p.: 165-168 C; IR (KBr, nu/cm-1): 3085 (s), 2920 (m), 1604 (s), 656 (m), 487 (m); 1HNMR (CDCl3, 400 M, delta, ppm): 9.98 (s, 1H, N=CH), 4.30(s, 2H, C5H4),4.25 (s, 2H, C5H4),4.16 (s, 5H, C5H5),2.20(s, 2H, CH2);13C NMR (CDCl3, 100 M, delta, ppm): 167.6,161.0, 160.4, 137.2, 130.2, 121.3, 32.1; Anal. Cald. forC14H12N4SFe:C, 51.85; H, 3.70; N, 17.28; Found C, 51.68;H, 3.59; N, 17.51%.

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

Reference£º
Article; Liu, Yuting; Xin, Hong; Yin, Jingyi; Yin, Dawei; Transition Metal Chemistry; vol. 43; 5; (2018); p. 381 – 385;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

The important role of 1287-16-7

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

Name is Ferrocenylacetic acid, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1287-16-7, its synthesis route is as follows.,1287-16-7

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

The important role of 1287-16-7

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

Name is Ferrocenylacetic acid, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1287-16-7, its synthesis route is as follows.,1287-16-7

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

Some tips on Ferrocenylacetic acid

With the complex challenges of chemical substances, we look forward to future research findings about 1287-16-7,belong iron-catalyst compound

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenylacetic acid, and cas is 1287-16-7, its synthesis route is as follows.,1287-16-7

1) 1.2 mmol of ferrocenyl acetic acid and 1 mmol of 3- (4-chlorophenyl) -4-amino-5-mercapto-1,2,4-triazole were weighed out,Added to a dry 250mL single-necked flask,Then p-toluenesulfonic acid 0.12 mmol,Then 6 mL of DMF was added thereto,The glass rod is stirred to dissolve it.2)The round bottom flask was placed in a microwave reactor,380W under irradiation once every 30s,The duration of irradiation is 3min.After irradiation,cool down.3)Pour it into a crushed beaker,With potassium carbonate and potassium hydroxide pH = 7,Placed overnight,filter,Washed,dry,The crude product of 3- (4-chlorophenyl) -6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole was obtained,Using a solvent mixture of DMF and absolute ethanol in a volume ratio of 5: 1,The crude product was recrystallized,That is, a brown solid,The yield is 85%

With the complex challenges of chemical substances, we look forward to future research findings about 1287-16-7,belong iron-catalyst compound

Some tips on 1287-16-7

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenylacetic acid, and cas is 1287-16-7, its synthesis route is as follows.,1287-16-7

1)1.2 mmol of ferrocenyl acetic acid and 1 mmol of 3- (4-hydroxyphenyl) -4-amino-5-mercapto-1,2,4-triazole were weighed out,Added to a dry 250mL single-necked flask,Then, 0.15 mmol of p-toluenesulfonic acid,7 mL of DMF was further added thereto,The glass rod is stirred to dissolve it.2)The round bottom flask was placed in a microwave reactor,390W under irradiation once every 30s,The duration of irradiation was 4.5 min.After irradiation,cool down.3)Pour it into a crushed beaker,With potassium carbonate and potassium hydroxide pH = 7,Placed overnight,filter,Washed,dry,The crude product of 3- (4-hydroxyphenyl) -6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole was obtained,Using a solvent of DMF and absolute ethanol in a volume ratio of 3: 1 mixed solvent,The crude product was recrystallized,A brown solid,The yield was 83%

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

Some tips on 1287-16-7

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenylacetic acid, and cas is 1287-16-7, its synthesis route is as follows.,1287-16-7

1)1 mmol of ferrocenyl acetic acid and 1 mmol of 3-methyl-4-amino-5-mercapto-1,2,4-triazole were weighed out,Added to a dry 250mL single-necked flask,Then, 0.15 mmol of p-toluenesulfonic acid,7 mL of DMF was further added thereto,The glass rod is stirred to dissolve it.2)The round bottom flask was placed in a microwave reactor,360W under irradiation once every 30s,Irradiation duration of 5min.After irradiation,cool down.3)Pour it into a crushed beaker,With potassium carbonate and potassium hydroxide pH = 7,Placed overnight,filter,Washed,dry,A crude product of 3-methyl-6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole was obtained,With 80% aqueous ethanol recrystallization,A brown solid,The yield was 86%

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenylacetic acid