Category: 16009-13-5

16009-13-5, Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 16009-13-5, Name is Hemin

Multiple spectroscopic and magnetic techniques show that chloroquine induces formation of the mu-oxo dimer of ferriprotoporphyrin IX

Interaction of the antimalarial chloroquine (CQ) with ferriprotoporphyrin IX, Fe(III)PPIX, was investigated in aqueous solution (pH 7.4) and as a precipitate from aqueous medium at pH 5.0. In solution, spectrophotometric titrations indicated strong association (logKobs 13.3 ¡À 0.2) and a Job plot gave a stoichiometry of 1:2 CQ:Fe(III)PPIX. UV-visible absorbance and magnetic circular dichroism spectra of the complex were compared to various Fe(III)PPIX species. Close similarity to the spectra of the mu-oxo dimer, mu-[Fe(III)PPIX]2O, was revealed. The induction of this species by CQ was confirmed by magnetic susceptibility measurements using the Evans NMR method. The observed low-magnetic moment (2.25 ¡À 0.02 muB) could only be attributed to antiferromagnetically coupled Fe(III) centers. The value was comparable to that of mu-[Fe(III)PPIX]2O (2.0 ¡À 0.1 muB). In the solid-state, mass spectrometry confirmed the presence of CQ in the complex. Dissolution of this solid in aqueous solution (pH 7.4) resulted in a solution with a UV-visible spectrum consistent with the same 1:2 stoichiometry observed in the Job plot. Magnetic susceptibility measurements made on the solid using an Evans balance produced a magnetic moment (2.3 ¡À 0.1 muB) consistent with that in solution. Diffusion coefficients of CQ and its complex with Fe(III)PPIX were measured in aqueous solution (3.3 ¡À 0.3 and 0.6 ¡À 0.2 ¡Á 10- 10 m 2¡¤s- 1, respectively). The latter was used in conjunction with an empirical relationship between diffusion coefficient and molar volume to estimate the degree of aggregation. The findings suggest the formation of a 2:4 CQ:Fe(III)PPIX complex in aqueous solution at pH 7.4.

Multiple spectroscopic and magnetic techniques show that chloroquine induces formation of the mu-oxo dimer of ferriprotoporphyrin IX

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Chemistry can be defined as the study of matter and the changes it undergoes. 16009-13-5. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.16009-13-5, Name is Hemin, molecular formula is C34H32ClFeN4O4, introducing its new discovery.

Hemin improves insulin sensitivity and lipid metabolism in cultured hepatocytes and mice fed a high-fat diet

Hemin is a breakdown product of hemoglobin. It has been reported that the injection of hemin improves lipid metabolism and insulin sensitivity in various genetic models. However, the effect of hemin supplementation in food on lipid metabolism and insulin sensitivity is still unclear, and whether hemin directly affects cellular insulin sensitivity is yet to be elucidated. Here we show that hemin enhances insulin-induced phosphorylation of insulin receptors, Akt, Gsk3beta, FoxO1 and cytoplasmic translocation of FoxO1 in cultured primary hepatocytes under insulin-resistant conditions. Furthermore, hemin diminishes the accumulation of triglyceride and increases in free fatty acid content in primary hepatocytes induced by palmitate. Oral administration of hemin decreases body weight, energy intake, blood glucose and triglyceride levels, and improves insulin and glucose tolerance as well as hepatic insulin signaling and hepatic steatosis in male mice fed a high-fat diet. In addition, hemin treatment decreases the mRNA and protein levels of some hepatic genes involved in lipogenic regulation, fatty acid synthesis and storage, and increases the mRNA level and enzyme activity of CPT1 involved in fatty acid oxidation. These data demonstrate that hemin can improve lipid metabolism and insulin sensitivity in both cultured hepatocytes and mice fed a high-fat diet, and show the potential beneficial effects of hemin from food on lipid and glucose metabolism.

Hemin improves insulin sensitivity and lipid metabolism in cultured hepatocytes and mice fed a high-fat diet

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Reference£º
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

16009-13-5, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 16009-13-5, name is Hemin, introducing its new discovery.

Preparation of metal mesoporphyrin halide compounds

A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Preparation of metal mesoporphyrin halide compounds

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.16009-13-5, you can also check out more blogs about16009-13-5

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. 16009-13-5, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 16009-13-5, name is Hemin. In an article£¬Which mentioned a new discovery about 16009-13-5

Investigation of a deoxyribozyme as a biofuel cell catalyst

We examined the ability of a previously identified peroxidase deoxyribozyme to be employed as a catalyst in biofuel cells, as a possible replacement for oxidoreductase proteins. We constructed a biocathode using a covalently linked version of the peroxidase deoxyribozyme-hemin complex and successfully paired it with a glucose dehydrogenase-modified bioanode for power production.

Investigation of a deoxyribozyme as a biofuel cell catalyst

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 16009-13-5 is helpful to your research. 16009-13-5

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

16009-13-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16009-13-5, Name is Hemin, molecular formula is C34H32ClFeN4O4. In a Article, authors is Poltorak£¬once mentioned of 16009-13-5

Adsorption of hematin on solid carriers

It was found that the adsorption of hematin on the surface of solid carriers (alumogel and graphitized carbon black and alumogel and graphitized carbon black modified with adsorbed lecithin) is a reversible and equilibrium process, because the adsorption and desorption branches of the obtained isotherms coincide. The adsorption isotherms were shown to be of Langmuir type. The corresponding Langmuir equation parameters were calculated. These parameters can be considered effective, because the adsorbate is a solution containing an equilibrium mixture of active monomers and inactive associates (dimers); therefore, the curves of sorption are overall isotherms of adsorption of the equilibrium forms of hematin. A kinetic analysis showed that the redistribution of the composition of the associates in the adsorption layers of hematin on the solid carriers under study is accomplished through the solution.

Adsorption of hematin on solid carriers

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.16009-13-5. In my other articles, you can also check out more blogs about 16009-13-5

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 16009-13-5, Name is Hemin, molecular formula is C34H32ClFeN4O4, 16009-13-5, In a Article, authors is Okada, Akiko£¬once mentioned of 16009-13-5

Analysis of the binding of bovine and human fibrinogen to ferritin: Evidence that fibrinogen is a common ferritin-binding protein in mammals

Both human and horse fibrinogen are heme-binding proteins, and horse fibrinogen also exhibits heme-mediated ferritin binding. This study found that bovine and human fibrinogen are heme-mediated ferritin-binding proteins and demonstrated direct binding of bovine ferritin to protoporphyrin (PPIX) and its derivatives or to Zn ions. Binding of bovine and human fibrinogen to bovine spleen ferritin coated on microtiter plate wells was detected using an anti-human fibrinogen antibody, and this binding was inhibited in a dose-dependent manner by hemin (iron-PPIX) and also inhibited by Zn-PPIX. PPIX showed less of an inhibitory effect on the binding of bovine and human fibrinogen to bovine ferritin. The inhibitory effect of Sn-PPIX was similar to that of PPIX, but with respect to human fibrinogen, PPIX did not inhibit the binding of human fibrinogen to ferritin. Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. The fibrinogen beads also directly bound to zinc ions. These results suggest that bovine fibrinogen is a heme- and zinc-binding protein and that binding of circulating mammalian fibrinogen to ferritin is heme mediated. Analysis of the binding of bovine and human fibrinogen to ferritin: Evidence that fibrinogen is a common ferritin-binding protein in mammals Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.16009-13-5. In my other articles, you can also check out more blogs about 16009-13-5

Reference£º
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 16009-13-5, name is Hemin, introducing its new discovery. 16009-13-5

A protoporphyrin disodium preparation method (by machine translation)

The present invention provides a kind of protoporphyrin disodium preparation method, which belongs to the field of synthetic organic compounds, comprising the following steps: the protoporphyrin, anhydrous methanol and concentrated sulfuric acid is in ultrasonic under the condition of alkyd reaction, to obtain the protoporphyrin diester; the protoporphyrin diester, NaOH methanol solution and toluene in the ultrasonic under the condition of saponification reaction, to obtain the protoporphyrin disodium. This invention adopts the ultrasonic auxiliary replacing high temperature reflow, preparation of the protoporphyrin disodium, the preparation process is not needed in the preparation of the hydrogen chloride gas and also avoid the use of chloroform strong toxic reagent, also does not need to use high-temperature conditions, the process is simplified, the whole process is easy to operate. (by machine translation)

A protoporphyrin disodium preparation method (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.16009-13-5, you can also check out more blogs about16009-13-5

Reference£º
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion