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Screen-printed electrodes (SPEs) have gone through significant improvements over the past few decades with respect to both their format and their printing materials. Thus, SPEs have been successfully applied for the in situ detection of a plethora of analytes in a wide range of sample matrixes due to their advantageous material properties, such as disposability, simplicity, and rapid responses. In particular, the development of electrochemical sensors based on SPEs for pharmaceutical analysis has received massive consideration since they enable the rapid screening of the pharmaceutical compounds in complex matrixes, requiring small volumes of samples and no pre-treatment steps. This review summarizes the design and the working principles of electrochemical sensors based on SPEs applied to the quantification of pharmaceutical and biological compounds.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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Polysiloxane-encapsulated “Pd”-nanoclusters were generated by reduction of Pd(OAc)2 with polymethylhydrosiloxane, which functions as a reducing agent as well as a capping material for production and stabilization of catalytically active “Pd”-nanoparticles. Chemoselective hydrogenation of functional conjugated alkenes was achieved by in-situ- or ex-situ-generated polysiloxane-stabilized “Pd”- nanoclusters under mild reaction conditions in high yields. Electron microscopy, UV-vis, and NMR studies of the reaction mixture during the catalytic transformation were performed and, in conjunction with catalyst poisoning experiments, demonstrated unequivocally the role of polysiloxane-encapsulated “Pd”-nanoclusters as the real catalytic species. The recyclability of the “Pd”-nanoclusters was established by reusing the solid left after the reaction.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; Quality Control of 1,1′-Diacetylferrocene, or in a public-sector research center, helping to ensure national healthcare provision keeps pace with new discoveries.In a article, mentioned the application of 1273-94-5, Name is 1,1′-Diacetylferrocene, molecular formula is C14H6FeO2

New ferrocenyl compounds substituted by sulfur containing groups were synthesized leading to ferrocenyl-3H-1,2-dithiole-3-thiones and related compounds. The substituent of the ferrocene was a [3-thioxo-3H-1,2-dithiol]-4 or 5-yl, a [3-oxo-3H-1,2-dithiol]-4 or 5- yl or a [3-methylsulfanyl-3H-1,2-dithiolium]-4 or 5-yl cation group. Their anodic behavior was studied by cyclic voltammetry at a Pt electrode in aprotic solvent. All synthesized ferrocenes exhibited a one-electron reversible oxidation leading to the corresponding ferricinium cation. At low potential scan, the irreversible oxidation of 5-ferrocenyl-3H-1,2-dithiole-3-thione was observed and attributed to a dimerization involving the dithiolethione group. Redox potential of the reversible oxidation allowed the determination of the electronic effect of the 1,2-dithiole groups. The Hammett sigmap constants of the dithiole substituents were obtained from linear correlation between oxidation potentials and electronic effects. The results showed that the [3-thioxo-3H-1,2-dithiol]-5-yl and the [3-methylsulfanyl-3H-1,2-dithiolium]-5-yl cation groups were strong inductive electron withdrawing substituents characterized by sigmap values of 0.55 and 0.97, respectively.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. COA of Formula: C11H3FeO. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. Introducing a new discovery about 1273-86-5, Name is Ferrocenemethanol

The discovery of novel drugs against animal parasites is in high demand due to drug-resistance problems encountered around the world. Herein, the synthesis and characterization of 27 organic and organometallic derivatives of the recently launched nematocidal drug monepantel (Zolvix) are described. The compounds were isolated as racemates and were characterized by1H,13C, and19F NMR spectroscopy, mass spectrometry, and IR spectroscopy, and their purity was verified by microanalysis. The molecular structures of nine compounds were confirmed by X-ray crystallography. The anthelmintic activity of the newly designed analogues was evaluated in vitro against the economically important parasites Haemonchus contortus and Trichostrongylus colubriformis. Moderate nematocidal activity was observed for nine of the 27 compounds. Three compounds were confirmed as potentiators of a known monepantel target, the ACR-23 ion channel. Production of reactive oxygen species may confer secondary activity to the organometallic analogues. Two compounds, namely, an organic precursor (3 a) and a cymantrene analogue (9 a), showed activities against microfilariae of Dirofilaria immitis in the low microgram per milliliter range.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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Amphiphilic polymers have attracted extensive research attention in constructing various nanostructures by self-assembly. Here we designed and synthesized two amphiphilic bimetallic polymers with different length of the tails P1 and P2, in which Fe,Pt-containing conjugated complex acted as the hydrophobic block and hydrophilic poly(ethylene glycol)(PEG)was bonded to the bimetallic core as the flexible tails. P1 and P2 were used as the single-source precursors to prepare FePt nanoparticles (NPs)by one-pot pyrolysis. The resultant NPs were fully characterized and had a chemically ordered face-centered tetragonal (fct)phase with high crystallinity. The size of NPs pyrolyzed from P1 and P2 was 24.7 and 8.2 nm with the relative coercivity of 9.6 and 1.3 kOe, respectively. The difference was preliminarily explained by the discrepancy of their degrees of crystallinity, and also analyzed by the precursors? structural effect. The amphiphilic design showed a good potential in preparing monodisperse ferromagnetic FePt NPs, and the possible favorable properties of self-assembly might provide a bright venue for future magnetic recording media.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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Surface-enhanced resonance Raman spectra of oxyhemoglobin on colloidal silver dispersions have been obtained with no observable denaturation resulting from adsorption at the silver surface.Excitation profiles of the SERR bands of oxyhemoglobin indicate that perturbations of the electronic states of the oxyhemoglobin occur upon adsorption, although the vibrational mode frequencies are unperturbed.An unusual enhancement of the bands associated with symmetric vibrational modes of the porphyrin macrocycle is reported for excitation of SERR spectra in wavelength region of the beta band.This is interpreted in terms of the lowered symmetry of the adsorbed species.

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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The synthesis of a series of ferrocenylanthracene derivatives is described, utilising the palladium catalysed coupling reaction of 1,1?-bis(chlorozincio)ferrocene with halo-anthracenes. Bis-1,1?-(9-anthracenyl)ferrocene (1) was characterised by single crystal X-ray diffraction and shows an eclipsed ferrocenyl geometry. X-ray crystallographic studies indicate that there are no clear stacking interactions of either an intra-or intermolecular nature between the anthracenyl rings in the structure. A series of 9-and 10-disubstituted ferrocenylanthracene derivatives has also been prepared. In each case the palladium catalyst (Pd(dppf)Cl2) is recovered in a modified form, e.g. as the [(dppf)PdBr(9-anthracenyl)] complex in the synthesis of bis-1,1?-(9-anthracenyl)ferrocene. The single crystal X-ray structure of one such palladium complex [(dppf)PdBr-{9-(10-chloroanthracenyl)}] (15a) has been determined in a case where chloride/bromide exchange had occurred in the palladium complex intermediate. The potential application of compound 1 as synthon for the construction of a molecular sensing device is discussed. Cyclic voltammetry and fluorescence studies have been carried out for selected derivatives.

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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The iron 2p and carbon 1s near-edge X-ray absorption fine structure (NEXAFS) spectra of substituted ferrocene compounds (Fe(Cp-(CH3) 5)2, Fe(Cp)(Cp-COOH), Fe(Cp-COOH)2, and Fe(Cp-COCH3)2) are reported and are interpreted with the aid of extended Hiickel molecular orbital (EHMO) theory and density functional theory (DFT). Significant substituent effects are observed in both the Fe 2p and C 1s NEXAFS spectra. These effects can be related to the electron donating/withdrawing properties of the cyclopentadienyl ligands and their substituents as well as the presence of pi* conjugation between the cyclopentadienyl ligand and unsaturated substituents.

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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By using an oxidizing directing group, a mild, efficient Rh(III) catalyzed C-H olefination reaction between N-phenoxyacetamides and alkenes was developed. This reaction provided a straightforward way for the synthesis of ortho-alkenyl phenols, and the directing group is traceless in the product.

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Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

 

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A novel asymmetric 1,1?-ferrocene-derived Schiff base ligand has been prepared by the condensation reaction of 1,1?-diacetylferrocene with 2-aminopyridine and 2-aminothiazole. Its transition metal complexes of the type [M(L)]Cl2 and [M(L)(Cl2)] [M = Cu(II),Co(II) and Ni(II)] have been prepared and characterized by their physical, analytical and spectral data. The Cu(II) complex shows square-planar whereas the Co(II), Ni(II) and Zn(II) complexes show octahedral geometry.

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Reference:
Iron Catalysis in Organic Synthesis | Chemical Reviews,
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion