Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

Acetophenone (120mg, 1mmol), cat.1 (5.4mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol,0.1equiv.), Ferrocene methanol (238mg, 1.1mmol) and tert-amyl alcohol (1ml) were sequentially added to 5mL round bottom flask.After the reaction mixture was refluxed in air for six hours, cooled to room temperature. The solvent is removed by rotary evaporation, then purified by column chromatography (developingOpen solvent: petroleum ether / ethyl acetate) to give pure target compound, yield: 82%

1273-86-5, The synthetic route of 1273-86-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanjing University of Science and Technology; Ma, Juan; Li, Lei; Li, Feng; (17 pag.)CN105439787; (2016); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1273-86-5,Ferrocenemethanol,as a common compound, the synthetic route is as follows.

General procedure: 1.1 mmol of triethylamine was added to a stirred mixture of 1.0 mmol of metallocene alcohol (7, 8, 12) or 0.45 mmol of ferrocene diol (10, 11) and 1.0 mmol of 4,5-dichloroisothiazole- or 5-arylisoxazole-3-carbonyl chloride in 50 mL of diethyl ether at 20-23C. The reaction mixture was stirred at that temperature during 24 h. The precipitated triethylamine hydrochloride was filtered off and washed with diethyl ether (5 ¡Á 10 mL). The filtrate was washed with 10 % aqueous NaCl and 5 % aqueous NaHCO3. The solvent was removed, and the residue was recrystallized from a benzene-hexane (2 : 1) mixture (14, 15, 19, and 20) or from hexane (16,17, 21, and 22). 3,4,4-Trichloro-1-cymantrenylbut-3-en-1-yl 4,5-dichloroisothiazole-3-carboxylate 18 was obtained as a viscous oil and was used without further purification.

1273-86-5, As the paragraph descriping shows that 1273-86-5 is playing an increasingly important role.

Reference£º
Article; Potkin; Dikusar; Kletskov; Petkevich; Semenova; Kolesnik; Zvereva; Zhukovskaya; Rosentsveig; Levkovskaya; Zolotar; Russian Journal of General Chemistry; vol. 86; 2; (2016); p. 338 – 343; Zh. Obshch. Khim.; vol. 86; 2; (2016); p. 338 – 343,6;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.

General procedure: Synthesized according to general procedure C using hydrazone (0.0800 g, 0.255 mmol), vinyl-ferrocene (0.0541 g, 0.255 mmol) in trifiuorotoluene (1.28 mL) and heated at 80 C for three hours. Volatiles were removed and the crude product was isolated by column chromatography with 100% CH2CI2, then 50% EtOAc/w-hexanes and gradually increased to 100% EtOAc. The title compound was obtained as dark red crystals (0.1024 g, 0.237 mmol, 93 % isolated yield). TLC Rf = 0.22 in 100 % EtOAc. ? NMR (CDC13, 300 MHz) delta ppm 8.90 (d, J = 7.6, 1H), 7.97 (dd, J = 7.1, 4.0, 2H), 7.62-7.48 (m, 4H), 7.30 (t, J = 7.5, 1H), 6.35-6.33 (m, 1H), 4.36 (d, J = 20.6, 2H), 4.15 (d, J = 0.3, 1H), 3.84 (s, 1H), 3.34-3.33 (m, 12H), 3.14 (d, J = 15.7, 1H); 13C NMR (CDC13, 100 MHz) delta ppm 184.3, 140.7, 139.9, 138.3, 132.2 (CH), 131.1 (CH), 130.3 (CH), 129.8 (C), 129.3 (CH), 128.6 (CH), 127.0 (CH), 121.5 (CH), 120.9 (CH), 89.2 (C), 69.5 (CH), 69.3 (CH), 67.8 (CH), 67.5 (CH), 67.4 (CH), 66.6 (CH), 40.4 (CH2); IR (film); 3086, 2975, 1664, 1546, 1273, 1120, 733 cm”1; HRMS (EI): Exact mass calcd for C28H26FeiN20i[M]+: 432.0925; found: 432.0951.

1271-51-8, As the paragraph descriping shows that 1271-51-8 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITY OF OTTAWA; BEAUCHEMIN, Andre Martin; CLAVETTE, Christian; GAN, Wei; MARKIEWICZ, Thomas; TODERIAN, Amy Beverly; WO2013/67646; (2013); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1273-86-5, Ferrocenemethanol is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Cyanuric chloride (TCT)(0.184g, 1mmol) was added intoa 50mL one-necked round-bottom flask with 10mL dry THF.The mixture was stirred in a cold bath and ferrocenemethanol(0.864g, 4mmol) in 10mL dry THF was slowly added tothe reaction system using a syringe. The mixture was stirred in the cold bath for 30min. Subsequently, DMAP (0.366g,3mmol) in 10mL dry THF was also slowly added to the reactionsystem using a syringe. The mixture was stirred in thecold bath for an additional 30min. Then, the temperature naturally rose to room temperature and was stirred for 8h.This time, the reaction system was refluxed. After the completion of the reaction indicated by simple TLC analysis, the solvent was evaporated under the reduced pressure, and theresidual was directly purified by column chromatography(EtOAc/Petroleum ether: 5:12:1) to obtain the target compound 1. 0.506g, light yellow solid, yield, 70%, Mp.:199-201 oC, 1H NMR(400MHz, CDCl3) (ppm): 4.73(s, 6H,32H of C5H4), 4.38(s, 6H, 32H of C5H4), 4.15(s, 15H,3C5H5), 4.10(s, 6H, 3CH2); 13C NMR(100MHz, CDCl3) (ppm): 148.7(3C=N), 81.5(6C), 70.4(6C), 68.7(15C),68.5(3C), 42.1(3CH2); ESI-MS(m/e, 100%) 746([M+23]+,100); Anal.calcd. for C36H33N3O3Fe3: N, 5.81; C, 59.75; H,4.56; Found: N, 5.75; C, 59.57 ; H, 4.64

1273-86-5, The synthetic route of 1273-86-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yong, Jianping; Wu, Xiaoyuan; Liao, Jianzhen; Lu, Canzhong; Liu, Xiaolong; Medicinal Chemistry; vol. 12; 5; (2016); p. 426 – 431;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-42-7, Ferrocenecarboxylic acid is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 50mL three necks round bottom flask and under nitrogen atmosphere, 1mmol of ferrocenecarboxylic acid was dissolved in 15mL of dry dichloromethane at room temperature. To this solution, 170-200muL of oxalyl chloride was added dropwise and stirred overnight. The solution changed from orange to dark red. The reaction mixture was filtered in a fritted funnel and the filtrate collected. In a separate 100mL three necks round flask under nitrogen, 1.0mmol of the 4-X-phenol and 1.0mmol of pyridine were dissolved in 10-15mL of dichloromethane. To this solution, the ferrocenecarbonyl chloride solution prepared previously was added dropwise. The solution was stir 6-12hin the dark, under nitrogen atmosphere, and at room temperature. Thin layer chromatography (TLC) was used to monitor the reaction. After the reaction was finished, the mixture was filtered in a fritted funnel with a pad of celite. The filtrate collected was washed with 3¡Á5mL 1N HCl to remove pyridine and other by-products. The organic layer containing the compound was purified by column chromatography, using Silica gel and eluted with dichloromethane and isolated in 40-45% yield.

1271-42-7, 1271-42-7 Ferrocenecarboxylic acid 499634, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Vera, Jose L.; Rullan, Jorge; Santos, Natasha; Jimenez, Jesus; Rivera, Joshua; Santana, Alberto; Briggs, Jon; Rheingold, Arnold L.; Matta, Jaime; Melendez, Enrique; Journal of Organometallic Chemistry; vol. 749; (2014); p. 204 – 214;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

1271-55-2, Acetylferrocene is a iron-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 1.14 g (5 mmol) of acetylferrocene, 5 mmol of the corresponding aromatic aldehyde, 50 mL of ethanol, and 2.5 g (45 mmol) of potassium hydroxide was stirred for 12 h at room temperature. The mixture was poured onto ice, and the precipitate was filtered off and purified by silica gel column chromatography using methylene chloride (2, 4) or methylene chloride-hexane (19 : 1) (3) as eluent. 1-Ferrocenyl-3-(4-fluorophenyl)prop-2-en-1-one(2). Yield 85%,

1271-55-2, 1271-55-2 Acetylferrocene 79159, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Antuf?eva; Zhulanov; Dmitriev; Mokrushin; Shklyaeva; Abashev; Russian Journal of General Chemistry; vol. 87; 3; (2017); p. 470 – 478; Zh. Obshch. Khim.; vol. 87; 3; (2017); p. 465 – 473,9;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-51-8,Vinylferrocene,as a common compound, the synthetic route is as follows.

General procedure: As shown as the synthetic protocol A in Scheme 2, compounds 1-11 were synthesized following literature description [16] with m-methoxyphenol, p-methoxyphenol, resorcinol, and hydroquinone as reagents. One hydroxyl group in resorcinol and hydroquinone was protected by tert-butyldimethylsilyl chloride. Then, 17 mL of dry CHCl3 solution containing excess PhtNSCl was added dropwisely to 8 mL of dry CHCl3 solution containing monoprotected hydroquinone or resorcinol and stirred for 16 h at 0 ¡ãC until phenols cannot be detected by thin layer chromatography (TLC). The mixture was diluted with CH2Cl2 and washed by saturated NaHCO3 and water. The organic phase was dried over anhydrous Na2SO4, and the solvent was removed under vacuum. The residue was purified by column chromatography with CH2Cl2 as the eluent to afford thiophthalimides as colorless solid. The following cycloaddition reactions were carried out in dry CHCl3 solution of thiophthalimides (~ 0.1 M) and styrenes (2 equiv.) or vinyl ferrocene (2 equiv.) and freshly distilled (C2H5)3N (2 equiv.) at 60 ¡ãC. The reaction was finished with thiophthalimides not detected by TLC. Then, the solvent was evaporated under vacuum pressure, and the residual solid was purified with column chromatography to afford silylated adducts. The desilylation operation was performed in dry tetrahydrofuran (THF) solution containing 0.04 M aforementioned adducts at 0 ¡ãC, to which a solution of (n-C4H9)4NF*3H2O in THF (1 equiv. for each protective group) was added. The reaction was finished with the reagent not detected by TLC, and then the mixture was diluted with ethyl acetate and washed with saturated NH4Cl and water. The organic layer was dried over anhydrous Na2SO4, and the solvent was evaporated under vacuum pressure. The residue was purified with column chromatography to afford thiaflavans.

1271-51-8, 1271-51-8 Vinylferrocene 16211828, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Lai, Hai-Wang; Liu, Zai-Qun; European Journal of Medicinal Chemistry; vol. 81; (2014); p. 227 – 236;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Acetylferrocene, cas is 1271-55-2, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-55-2

To a solution of 172 mg KOH (3.07 mmol) in 10 cm3 of EtOH/H2O (1:1) at r.t., 1 g of acetylferrocene(4.38 mmol) was added, followed by dropwise addition of 0.45 cm3 benzaldehyde (4.38 mmol). The thus prepared darkviolet solution was stirred at r.t. for 3 days. Then the reaction mixture was extracted with CH2Cl2(3 ¡Á 10 cm3). The collected organic layers were dried over Na2SO4 and filtered,and the resulting solution was evaporated under reduced pressure to afford the crude product. Isolated enone 9 was characterized and used in the subsequent reaction without further purification. Dark-red crystalline solid (1.28 g, yield:93%); m.p.: 112-118 C; 1H NMR (600 MHz, CDCl3):delta = 7.81 (d, J = 15.7 Hz, 1H), 7.68-7.63 (m, 2H), 7.45-7.39(m, 3H), 7.14 (d, J = 15.6 Hz, 1H), 4.92-4.91 (m, 2H),4.61-4.57 (m, 2H), 4.21 (s, 5H) ppm; 13C NMR (150 MHz,CDCl3):delta = 192.8, 140.8, 135.1, 130.1, 128.9, 122.9, 80.6,72.7, 70.1, 69.7, 69.7 ppm; IR (neat): = 1648 (s, C=O),1595 (m, C=C), 1456 (m, C-H), 1376 (m, C-H), 1280 (w,C-H), 1079 (m, C-H), 993 (w, C-H), 821 (m, C-H), 757(m, C-H), 687 (m, C-H), 544 (w, C-H), 499 (s, C-H), 480 (s, C-H) cm-1; HRMS (ESI): m/z found 317.0621, calcd forC19H17FeO+([M + H+]) 317.0629.

With the rapid development of chemical substances, we look forward to future research findings about 1271-55-2

Reference£º
Article; Mravec, Bernard; Plevova, Kristina; ?ebesta, Radovan; Monatshefte fur Chemie; vol. 150; 2; (2019); p. 295 – 302;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Vinylferrocene, cas is 1271-51-8, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-51-8

Under argon, into a dried reactor were added successively vinyl ferrocene (1mol, 212g), (R ) -3,3′-bis (3,5-dimethylphenyl) -1,1 ‘ – binaphthol phosphonate (0.01mol, 5.6g) and 1L of toluene, followed by addition of di-tert-butylphosphine (1mol, 147g), heated to 60 deg.] C for 12 hours, then cooled cooling, water was added dropwise to the system, and then liquid separation, the organic layer was dried over anhydrous magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to give a yellow solid which was recrystallized from dichloromethane and methanol to give (R) -1- ferrocenyl ethyl-di-tert-butylphosphine 347g yield 97percent, ee value of 99.5percent.

With the rapid development of chemical substances, we look forward to future research findings about 1271-51-8

Reference£º
Patent; Institute of Chemistry, Henan Academy of Sciences; Chen, Hui; Yang, Ruina; Yang, Zhenqiang; Sun, Minqing; Duan, Zheng; Wang, Congyang; (5 pag.)CN105859800; (2016); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-42-7,Ferrocenecarboxylic acid,as a common compound, the synthetic route is as follows.

In a three-necked flask, 4.6 g (0.02 mmol) of dry ferrocenecarboxylic acid and 80 mL of anhydrous benzene were added.Under nitrogen protection,6.24 g (0.03 mmol) of phosphorus pentachloride was slowly added in several portions, and stirred at room temperature for 3 h.The benzene is distilled off under reduced pressure, and petroleum ether (60-90 C) is extracted to obtain a deep red solution, distilled under reduced pressure, and cooled.Dark red needle crystals are precipitated, yield 80%

1271-42-7, 1271-42-7 Ferrocenecarboxylic acid 499634, airon-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Guilin Medical University; Huang Wanyun; Liao Ying; Peng Xiangyan; Yin Penglong; Liao Yueying; (13 pag.)CN104788503; (2017); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion