Tag: M.W:200-300

It is a common heterocyclic compound, the iron-catalyst compound, Ferrocenecarboxaldehyde, cas is 12093-10-6 its synthesis route is as follows.,12093-10-6

To a solution of hydroxylamine hydrochloride (0.83 g,11.97 mmol) in methanol (10 mL) was added sodium carbonate(0.63 g, 5.98 mmol). The mixture was stirred for 5 min. Then, ferrocenecarboxaldehyde1 (2.33 g, 10.88 mmol) was added and the reaction mixture was stirred at room temperature for 12 h. The precipitate formed was then filtered off and the filtrate was evaporated in vacuo. The product was washed with hexane (10 mL) toafford the pure ferrocenecarboxaldehyde oxime 4 in ca. 85% yield(Scheme 2).

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenecarboxaldehyde

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Article; Lasri, Jamal; Elsherbiny, Abeer S.; Eltayeb, Naser Eltaher; Haukka, Matti; El-Hefnawy, Mohamed E.; Journal of Organometallic Chemistry; vol. 866; (2018); p. 21 – 26;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Ferrocenylacetic acid, and cas is 1287-16-7, its synthesis route is as follows.,1287-16-7

1) 1.2 mmol of ferrocenyl acetic acid and 1 mmol of 3- (4-chlorophenyl) -4-amino-5-mercapto-1,2,4-triazole were weighed out,Added to a dry 250mL single-necked flask,Then p-toluenesulfonic acid 0.12 mmol,Then 6 mL of DMF was added thereto,The glass rod is stirred to dissolve it.2)The round bottom flask was placed in a microwave reactor,380W under irradiation once every 30s,The duration of irradiation is 3min.After irradiation,cool down.3)Pour it into a crushed beaker,With potassium carbonate and potassium hydroxide pH = 7,Placed overnight,filter,Washed,dry,The crude product of 3- (4-chlorophenyl) -6-ferrocenylmethylene-1,2,4-triazolo [3.4-b] -1,3,4-thiadiazole was obtained,Using a solvent mixture of DMF and absolute ethanol in a volume ratio of 5: 1,The crude product was recrystallized,That is, a brown solid,The yield is 85%

With the complex challenges of chemical substances, we look forward to future research findings about 1287-16-7,belong iron-catalyst compound

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Patent; Shaanxi University of Science and Technology; Liu, Yuting; Song, Simeng; Yin, Dawei; Jiang, Shanshan; Liu, Beibei; Yang, Aning; Wang, Jinyu; Lyu, Bo; (13 pag.)CN104231004; (2017); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

As a common heterocyclic compound, it belongs to iron-catalyst compound, name is Aminoferrocene, and cas is 1273-82-1, its synthesis route is as follows.,1273-82-1

Preparation of ferrocene derivatives (Fc04) [Reaction formula V] Reaction Formula V is the preparation of compound Fc04,The detailed preparation step was the same as the step (1) of Example 1,The difference is that,The amount of 4-bromobiphenyl added to the present example was 840 mg (3.61 mmol)And the stripping system used in the purification process of column chromatography was 3: 1 (v / v) of n-hexane with ethyl acetate,And after the column chromatography purification requires two sublimation steps,The final compound Fc04 solid (yield 42%) was obtained. A solution of 300 mg (1.49 mmol) of the amine ferrocene obtained in Preparation Example 1,380 mg (1.64 mmol) of 4-bromobiphenyl (4-bromobiphenyl)17 mg (0.075 mmol) of palladium acetate [Pd (OAc) 2]67 mg (0.12 mmol) of 1,1′-bis (diphenylphosphino) ferrocene (dppf) and 577 mg (6 mmol) of sodium tert-butoxide (NaOtBu)And with 5 mL of toluene as solvent,The reaction was carried out at 90 C for 72 hours,And then into the pure water,Extracted with 60 mL of ether 5 times,The resulting organic layer was washed with anhydrous magnesium sulfate and the solvent was removed,Purification by column chromatography [3: 2 (v / v) n-hexane and ethyl acetate]

With the complex challenges of chemical substances, we look forward to future research findings about 1273-82-1,belong iron-catalyst compound

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Patent; Zheng, Jianhong; Lai, Zhenchang; Zhang, Yuwei; Liao, Chunyi; Huang, Minjie; (31 pag.)CN106317129; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Name is Aminoferrocene, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1273-82-1, its synthesis route is as follows.,1273-82-1

The aminoferrocene compound (300 mg, 1.5 mmol) obtained in Preparation Example 1,4?-bromo-N,N-diphenylbiphenyl-4-amine (1.8 g, 4.5 mmol), palladium acetate (Pd(OAc)2, 17 mg, 0.075 mmol), a solution of tributylphosphine in n-hexane (0.1 ml, 10 wt %), and sodium tert-butoxide (NaOtBu, 1.13 g, 11.8 mmol) were mixed in toluene (6 ml, as a solvent). A reaction was conducted at 130 C. for 72 hours. Pd(dba)2 was filtered using diatomaceous earth and silica gel. The reaction was washed using ethyl acetate and the solvent was removed. Purification was conducted by column chromatography (eluent: n-hexane/ethyl acetate in a gradient from 4/1 to 3/2 (v/v)) to obtain compound DPABPAFc (yield: 50%). The structure of compound DPABPAFc is shown in scheme III. Preparation of Compound Fc02: (0046) Compound Fc02 was prepared by a process similar to that for preparing compound DPABPAFc except that the amount of 4?-bromo-N,N-diphenylbiphenyl-4-amine was 7.90 g (19.7 mmol) and that sublimation (two times) was conducted after column chromatography. Compound Fc02 was obtained in the formed of a red solid (yield: 40%). (0047) Analysis for compound DPABPAFc: 1H NMR (400 MHz. CDCl3): delta 7.42 (t, J=8.0 Hz, 4H), 7.24 (t, J=8.0 Hz, 4H), 7.11 (d, J=8.0 Hz, 4H), 7.00 (t, J=7.2 Hz, 2H), 6.92 (d, J=7.6 Hz, 2H), 4.89 (br, 1H), 4.29 (s, 2H), 4.21 (s, 5H), 4.08 (s, 2H); 13C NMR (100 MHz. CDCl3): delta 147.8, 146.2, 141.9, 135.3, 131.2, 129.2, 127.2, 127.0, 124.4, 124.1, 122.6, 115.1, 69.0, 64.7, and 61.8; HRMS (EI+, m/z) calculated for C34H28N2Fe: 520.1602. found: 520.1599. (0048) Analysis for compound Fc02: 1H NMR (400 MHz. CDCl3): delta 7.52 (d, J=8.4 Hz, 4H), 7.46 (d, J=8.8 Hz, 4H), 7.33 (d, J=8.4 Hz, 4H), 7.27-7.23 (m, 8H), 7.11 (d, J=8.4 Hz, 8H), 7.02 (d, J=8.0 Hz, 4H), 4.17 (s, 5H), 4.11 (s, 2H), 4.04 (s, 2H); 13C NMR (100 MHz. CDCl3): delta 147.7, 147.7, 146.5, 141.9, 135.0, 129.2, 127.5, 127.4, 127.2, 124.5, 124.3, 124.2, 124.0, 122.8, 122.7, 118.0, 69.0, 64.0, and 60.4; HRMS (FAB+, m/z) calculated for C58H46N3Fe: 840.3041. found: 840.3044.

With the complex challenges of chemical substances, we look forward to future research findings about Aminoferrocene

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Patent; NATIONAL TSING HUA UNIVERSITY; Cheng, Chien-Hong; Lai, Cheng-Chang; Chang, Yu-Wei; Liao, Chuang-Yi; Huang, Min-Jie; (16 pag.)US9356244; (2016); B1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Name is Aminoferrocene, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 1273-82-1, its synthesis route is as follows.,1273-82-1

A solution of 300 mg (1.49 mmol) of the amine ferrocene obtained in Preparation Example 1,380 mg (1.64 mmol) of 4-bromobiphenyl (4-bromobiphenyl)17 mg (0.075 mmol) of palladium acetate [Pd (OAc) 2]67 mg (0.12 mmol) of 1,1′-bis (diphenylphosphino) ferrocene (dppf) and 577 mg (6 mmol) of sodium tert-butoxide (NaOtBu)And with 5 mL of toluene as solvent,The reaction was carried out at 90 C for 72 hours,And then into the pure water,Extracted with 60 mL of ether 5 times,The resulting organic layer was washed with anhydrous magnesium sulfate and the solvent was removed,Purification by column chromatography [3: 2 (v / v) n-hexane and ethyl acetate]That is, the orange compound BPAFc is obtained(Yield 68%The structure is shown in Reaction Scheme II).

With the complex challenges of chemical substances, we look forward to future research findings about Aminoferrocene

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Patent; Zheng, Jianhong; Lai, Zhenchang; Zhang, Yuwei; Liao, Chunyi; Huang, Minjie; (31 pag.)CN106317129; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Name is Ferrocenecarboxaldehyde, as a common heterocyclic compound, it belongs to iron-catalyst compound, and cas is 12093-10-6, its synthesis route is as follows.,12093-10-6

General procedure: O-amino amides 1a-e (1 equiv.) and carbonyl compounds 2a-o (1.2 equiv.) were microwave irradiated (standard mode) in the presence of Phosphotungstic acid/HPW (50 % w/w) at 200 W for 3 min. After the completion of the reaction (Monitored by TLC), HPW was filtered off using celite bed/Silica bed. The crude product was purified on silica gel a column chromatography to afford the corresponding spiro and cyclic quinazolinones 3a-3n, 4a-4h, and 5a, 5b in very good yields except compounds 6a and 7a were obtained in poor yields (Eluent: n-Hexane /EtOAc). All the compounds 3a-3n, 4a-4h, 5a-b, 6a and 7a were thoroughly characterized by 1H NMR, 13CNMR, FTIR and HRMS.

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenecarboxaldehyde

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Article; Novanna, Motakatla; Kannadasan, Sathananthan; Shanmugam, Ponnusamy; Tetrahedron Letters; vol. 60; 2; (2019); p. 201 – 206;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

It is a common heterocyclic compound, the iron-catalyst compound, Ferrocenecarboxaldehyde, cas is 12093-10-6 its synthesis route is as follows.,12093-10-6

To a solution of ferrocenecarboxaldehyde (2) (4.28 g, 20 mmol) in acetone (100 mL) was added 2 N aq. NaOH (2 mL). The mixture was stirred at room temperature. After complete reaction (TLC analysis), the mixture was diluted with water and the precipitation was filtered to afford the crude product, which were purified by column chromatography using silica gel. 84% yield; brown solid, mp 125-127 C; 1H NMR (600 MHz, CDCl3): delta 7.42 (d, J = 16.0 Hz, 1H, CH=CH), 6.34 (d, J = 16.0 Hz, 1H, CH=CH), 4.50 (s, 2H, ferrocene-H), 4.44 (s, 2H, ferrocene-H), 4.15 (s, 5H, ferrocene-H), 2.29 (s, 3H, Me-H). MS (ESI): 255.1 (C14H14FeO, [M+H]+). Anal. Calcd for C14H14FeO: C, 66.17; H, 5.55; O, 6.30. Found: C, 66.23; H, 5.49; O, 6.36%.

With the complex challenges of chemical substances, we look forward to future research findings about Ferrocenecarboxaldehyde

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Article; Guo, Ying; Wang, Si-Qi; Ding, Zong-Qing; Zhou, Jia; Ruan, Ban-Feng; Journal of Organometallic Chemistry; vol. 851; (2017); p. 150 – 159;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1287-16-7,Ferrocenylacetic acid,as a common compound, the synthetic route is as follows.

Example 1 – Preparation of ferrocene modified phospholipid (3)[0064] Ferrocene modified phospholipid (FC-DSP) was prepared in the following manner: triethylamine (0.077 mmol, 0.01 ml_, 1.4 eq) and N,N-dicyclohexylcarbodiimide (0.077 mmol, 15.9 mg, 1.4 eq) were added to a solution that contained 1 ,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (0.055 mmol, 35 mg, 1.0 eq) and ferroceneacetic acid (0.077 mmol, 18.8 mg, 1.4 eq) in anhydrous DCM (1.5 ml_). The reaction was stirred overnight, until N MR indicated conversion to the coupling was completed. The solution was concentrated under vacuum and then was purified on iatrobeads gel chromatography ( 10% MeOH : DCM). A dark-brown oil (29.4 mg, 0.0341 mmol) was obtained (62% yield). H N MR (300 MHz, CDCI3) delta 7.04 (br, 1 H), 5.23 (br, 1 H), 4.37 (br, 1 H), 4.22 (br, 2H), 4.12 (br, 5H), 3.94 (br, 2H), 3.49 (br, 4H), 3.28 (br, 2H), 3.05 (br, 4H), 2.28 (br, 4H), 1.58 (br, 4H), 1.25 (br, 40H), 0.87 (t, J = 6.5 Hz, 6H).3P NMR (122 MHz, CDCI3) delta 0.15 (s).3C N MR (75 MHz, CDCI3) delta 173.60 (s), 173.21 (s), 70.56 (s), 69.26 (s), 68.92 (s), 68.14 (s), 62.82 (s), 45.87 (s), 34.44 (s), 34.25 (s), 32.05 (s), 29.80 (s), 29.65 (s), 29.49 (s), 29.29 (s), 25.02 (s), 22.81 (s), 14.24 (s), 8.73 (s). HRMS (ESI): Calc. for C45H76FeN09P (M+H)+: 862.4680; found : 862.4624., 1287-16-7

As the paragraph descriping shows that 1287-16-7 is playing an increasingly important role.

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Patent; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY; TRANSFERT PLUS SOCIETE EN COMMANDITE; MAUZEROLL, Janine; NOYHOUZER, Tomer Aharon; SNOWDEN, Michael Edward; DAUPHIN DUCHARME, Philippe; MAZURKIEWICZ, Stephani; L’HOMME, Chloe; DESJARDINS, Samuel; CANESI, Sylvain; (84 pag.)WO2016/115626; (2016); A1;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1271-55-2,Acetylferrocene,as a common compound, the synthetic route is as follows.

To a 100 mL round bottom reaction flask was added p-toluenesulfonyl hydrazide (1.5 eq)Methanol was gradually added until the p-toluenesulfonyl hydrazide was completely dissolved.Heated to 60oC,After a small amount of methanol was used to dissolve acetyl ferrocene (1 equivalent) prepared in the previous reaction,Was added dropwise to p-toluenesulfonyl hydrazide solution,Stirring to reflux to a large amount of solid precipitation.Suction filtered, washed with petroleum ether,Dry, getAcetylferrocene p-toluenesulfonyl hydrazone.Yield 81%.

1271-55-2, The synthetic route of 1271-55-2 has been constantly updated, and we look forward to future research findings.

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Patent; Inner Mongolia University; Zhang Hao; Ling Li; Hu Jianfeng; Huo Yanhong; (11 pag.)CN107226829; (2017); A;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion

Ferrocenecarboxylic acid, cas is 1271-42-7, it is a common heterocyclic compound, the iron-catalyst compound, its synthesis route is as follows.,1271-42-7

Will ferrocenecarboxylic acid (0.46g, 2mmol),N,N-Dicyclohexyl-carbodiimide (DCC, 0.453 g, 2.2 mmol)Add 1-hydroxybenzotriazole (HOBt, 0.337 g, 2.5 mmol) to a 100 mL round bottom flask and add 20 mLThe dried tetrahydrofuran was added and the mixture was stirred in an ice bath. 10 mL of a dry tetrahydrofuran solution containing DMAP (0.268 g, 2.2 mmol) was slowly added dropwise to the reaction system. After stirring in an ice bath for 30 minutes, the reaction was naturally warmed to room temperature. After the TLC detection reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue was directly separated by column.(V petroleum ether: Ethyl acetate V, 5:1-2:1) Elution of the mobile phase yields 0.638 g of compound Fc-D1., Yield: 92%.

With the rapid development of chemical substances, we look forward to future research findings about 1271-42-7

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Patent; Chinese Academy Of Sciences Fujian Structure Of Matter Institute; Yong Jianping; Lu Canzhong; (10 pag.)CN103319543; (2018); B;,
Iron Catalysis in Organic Synthesis | Chemical Reviews
Iron Catalysis in Organic Synthesis: A Critical Assessment of What It Takes To Make This Base Metal a Multitasking Champion